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Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphorothioic acid, O,O-dimethyl O-(4-nitro-m-tolyl) ester

RTECS #

TG0350000

CAS #

122-14-5

Updated

December 2012

Molecular Weight

277.25

Molecular Formula

C9H12NO5PS

Synonyms

3-Methyl-4-nitrophenyl dimethyl phosphorothioate
8057HC
AC-47300
Accothion
Agria 1050
Agriya 1050
Agrothion
American cyanamid CL-47,300
Arbogal
BAY 41831
Bayer 41831
Bayer S 5660
Cekutrothion
CL 47300
CP 47114
Dimethyl 3-methyl-4-nitrophenyl phosphorothionate
Dimethyl 4-nitro-m-tolyl phosphorothionate
EI 47300
ENT 25,715
Fenition
Fenitrothion
Fenitrotion (Hungarian)
Folithion
Folithion EC 50
Insectigas F
Kotion
Macbar
m-Cresol, 4-nitro-, O-ester with O,O-dimethyl phosphorothioate
MEP (pesticide)
Metathion
Metathion E 50
Metathione
Metathionine
Metathionine E50
Metation
Metation E50
Methylnitrophos
Mglawik F
Monsanto CP 47114
Novathion
Nuvanol
O,O-Dimethyl O-(3-methyl-4-nitrophenyl) phosphorothioate
O,O-Dimethyl O-(3-methyl-4-nitrophenyl) phosphorothionate
O,O-Dimethyl O-(3-methyl-4-nitrophenyl) thiophosphate
O,O-Dimethyl O-(4-nitro-3-methylphenyl)thiophosphate
O,O-Dimethyl O-4-nitro-m-tolyl phosphorothioate
O,O-Dimethyl-O-(3-methyl-4-nitrofenyl)-monothiofosfaat (Dutch)
O,O-Dimethyl-O-(3-methyl-4-nitro-phenyl)-monothiophosphat (German)
O,O-Dimethyl-O-(4-nitro-5-methylphenyl)-thionophosphat (German)
O,O-Dimetil-O-(3-metil-4-nitrofenil) fosforotioato (Portugese)
O,O-Dimetil-O-(3-metil-4-nitro-fenil)-monotiofosfato (Italian)
Oleosumifene
OMS 43
Ovadofos
Owadofos
Pennwalt C-4852
Phenitrothion
Phosphorothioic acid, O,O-dimethyl O-(3-methyl-4-nitrophenyl) ester
S 112A
S 5660
Sumifene
Sumithion
Sumitomo S-1102A
Super Sumithion
Thiophosphate de O,O-dimethyle et de O-(3-methyl-4-nitrophenyle) (French)
Tionofosforan O,O-dwumetylo-O-(3-metylo)-4-nitrofenylowy (Polish)
Verthion

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisleukocyte/human40 mg/LHOEKAN 29,33,1979
Cytogenetic Analysislymphocyte/human40 mg/LCHYCDW 20,354,1986
Cytogenetic Analysislung/hamster200 mg/LGMCRDC 27,95,1981
DNA inhibition/Other microorganisms100 ppmNNGADV 9,325,1984
mutation in microorganisms/Salmonella typhimurium500 µg/plate (+enzymatic activation step)MUREAV 116,185,1983
mutation in microorganisms/Salmonella typhimurium400 µg/plate (-enzymatic activation step)CHYCDW 20,354,1986
other mutation test systems/Other microorganisms100 ppmNNGADV 9,325,1984
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster5 ppmMUREAV 260,225,1991
sister chromatid exchangelung/hamster277 mg/LSNSHBT (20),574,1980
sister chromatid exchangeembryo/human55400 µg/LSNSHBT (20),574,1980
specific locus testoral/Drosophila melanogaster100 ppbMUREAV 260,225,1991

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 90 mg/kg (7-15D pregnant)Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Other postnatal measures or effects
NETEEC 11,321,1989
oral/rat 200 mg/kg (12-21D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathTOXID9 66,234,2002
oral/rat 250 mg/kg (12-21D pregnant)Reproductive: Specific developmental abnormalities: Urogenital systemTOXID9 66,234,2002
oral/rat 200 mg/kg (12-21D pregnant)Reproductive: Specific developmental abnormalities: Central nervous systemJAPTO* 27,631,2007

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Rat, neurons Inhibitor Concentration Low: 40 mg/L/2HBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTIVIEQ 3,111,1989
In Vitro/Rat, neurons Inhibitor Concentration (50 percent kill): >12.1 mg/L/2HBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTIVIEQ 3,111,1989
inhalation/rat lethal concentration (50 percent kill): 378 mg/m3/4HBehavioral: Tremor

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea
EGESAQ 24,173,1980
intracerebral/mouse lethal dose (50 percent kill): 1 gm/kgPCBPBS 8,302,1978
intraperitoneal/mouse lethal dose (50 percent kill): 280 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseABCHA6 25,605,1961
intraperitoneal/mouse lowest published toxic dose: 100 mg/kgBrain and Coverings: Other degenerative changesTOLED5 135,89,2002
intraperitoneal/rat lethal dose (50 percent kill): 300 mg/kgAutonomic Nervous System: Other (direct) parasympathomimetic

Lung, Thorax, or Respiration: Fibrosis (interstitial)
TXAPA9 63,91,1982
intratracheal/rat lethal dose (50 percent kill): 950 mg/kgAutonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Tremor

Lung, Thorax, or Respiration: Fibrosis (interstitial)
TXAPA9 63,91,1982
intravenous/guinea pig lethal dose (50 percent kill): 112 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Reactivates cholinesterase

Lung, Thorax, or Respiration: Dyspnea

Behavioral: Convulsions or effect on seizure threshold
ABCHA6 27,669,1963
intravenous/mouse lethal dose (50 percent kill): 220 mg/kgRREVAH 68,1,1977
intravenous/rat lethal dose (50 percent kill): 33 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Reactivates cholinesterase

Lung, Thorax, or Respiration: Dyspnea

Behavioral: Convulsions or effect on seizure threshold
ABCHA6 27,669,1963
oral/cat lethal dose (50 percent kill): 142 mg/kgABCHA6 25,605,1961
oral/chicken lethal dose (50 percent kill): 280 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
TXAPA9 11,49,1967
oral/chicken lethal dose (50 percent kill): 500 mg/kgHBPTO* 2,957,2001
oral/duck lethal dose (50 percent kill): 1190 mg/kgTXAPA9 47,451,1979
oral/guinea pig lethal dose (50 percent kill): 500 mg/kg85DPAN -,-,1971/1976
oral/human lowest published lethal dose: 1.79 gm/kgGastrointestinal: Changes in structure or function of salivary glands

Vascular: BP lowering not characterized in autonomic section

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
JTCTDW 46,528,2008
oral/mammal (species unspecified) lethal dose (50 percent kill): >727 mg/kgRREVAH 68,1,1977
oral/man lowest published lethal dose: 429 µL/kgBehavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Other changes
HUTODJ 6,403,1987
oral/mouse lethal dose (50 percent kill): 229 mg/kgTOIZAG 25,635,1978
oral/mouse lowest published toxic dose: 0.228 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseFCTOD7 46,3111,2008
oral/quail lethal dose (50 percent kill): 56200 µg/kgAECTCV 12,355,1983
oral/rat lethal dose (50 percent kill): 250 mg/kgJEENAI 61,743,1968
oral/wild bird lethal dose (50 percent kill): 11 mg/kgAECTCV 12,355,1983
oral/woman lowest published toxic dose: 800 mg/kgGastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting

Lung, Thorax, or Respiration: Dyspnea
ARTODN 56,136,1984
skin/duck lethal dose (50 percent kill): 504 mg/kgTXAPA9 47,451,1979
skin/mouse lethal dose (50 percent kill): 2500 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseABCHA6 25,605,1961
skin/rabbit lethal dose (50 percent kill): 1250 mg/kgGISAAA 31(10),12,1966
skin/rat lethal dose (50 percent kill): 1002 mg/kgAIBOA3 37,219,1970
subcutaneous/mouse lethal dose (50 percent kill): 1 gm/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseABCHA6 25,605,1961
subcutaneous/rat lethal dose (50 percent kill): 1300 mg/kgNNGADV 13,401,1988
unreported route/cattle lethal dose (50 percent kill): 217 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Behavioral: Change in motor activity (specific assay)
IJLAA4 49,314,1979
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 142 mg/kg30ZDA9 -,330,1971
unreported route/mouse lethal dose (50 percent kill): 470 mg/kgGTPZAB 7(5),38,1963
unreported route/rat lethal dose (50 percent kill): 290 mg/kgNYKZAU 74,41P,1978

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/cat lowest published toxic concentration: 3800 µg/m3/4H/9W- intermittentBlood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 31(10),12,1966
inhalation/rat lowest published toxic concentration: 12 mg/m3/2H/13W- intermittentBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
JOUOD4 10,71,1988
inhalation/rat lowest published toxic concentration: 17 mg/m3/17W- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseGISAAA 31(10),12,1966
inhalation/rat lowest published toxic concentration: 15 mg/m3/2H/4W- intermittentBrain and Coverings: Other degenerative changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NNGADV 13,401,1988
inhalation/rat lowest published toxic concentration: 57 mg/m3/2H/30D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 62,32,1982
oral/chicken lowest published toxic dose: 1960 mg/kg/2W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 11,49,1967
oral/domestic bird lowest published toxic dose: 22500 µg/kg/5D- continuousBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AECTCV 11,617,1982
oral/mouse lowest published toxic dose: 140 mg/kg/14D- intermittentBrain and Coverings: Other degenerative changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
FAATDF 33,246,1996
oral/mouse lowest published toxic dose: 20.7 mg/kg/90D- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
FCTOD7 46,3111,2008
oral/quail lowest published toxic dose: 179 mg/kg/4W- continuousBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
BOCKAF 40,54,1975
oral/rabbit lowest published toxic dose: 560 mg/kg/8W- intermittentPeripheral Nerve and Sensation: Structural change in nerve or sheathAPTOA6 39,374,1976
oral/rat lowest published toxic dose: 700 mg/kg/28D- intermittentLiver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Other changes

Blood: Hemorrhage
TIHEEC 24,581,2008
oral/rat lowest published toxic dose: 400 mg/kg/40D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTOTDY 3,313,1981
oral/rat lowest published toxic dose: 760 mg/kg/12W- intermittentBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
BCTKAG 11,151,1978
oral/rat lowest published toxic dose: 406 mg/kg/28D- continuousEndocrine: Hyperglycemia

Endocrine: Changes in adrenal weight

Blood: Other changes
TOLED5 11,187,1982
oral/rat lowest published toxic dose: 456 mg/kg/1Y- continuousCardiac: Changes in heart weight

Related to Chronic Data: Changes in uterine weight
JTSCDR 7,43,1982
oral/rat lowest published toxic dose: 15 mg/kg/5D- intermittentBrain and Coverings: Other degenerative changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
JTSCDR 25,403,2000
oral/rat lowest published toxic dose: 15 mg/kg/5D- intermittentBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
JTSCDR 25,403,2000
oral/rat lowest published toxic dose: 266.7 mg/kg/10W- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXCYAC 206,17,2005
oral/rat lowest published toxic dose: 155.9 mg/kg/113D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXCYAC 206,17,2005
oral/rat lowest published toxic dose: 252 mg/kg/10W- continuousBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 78,218,2004
oral/rat lowest published toxic dose: 113 mg/kg/113D- continuousBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 78,218,2004
oral/rat lowest published toxic dose: 200 mg/kg/10D- intermittentBehavioral: Tremor

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 66,234,2002
oral/rat lowest published toxic dose: 105 mg/kg/7D- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Change in motor activity (specific assay)

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
TOXID9 60,364,2001
oral/rat lowest published toxic dose: 105 mg/kg/7D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Changes in prostate weight
TOXID9 60,364,2001
skin/rabbit lowest published toxic dose: 10500 mg/kg/21D- intermittentBehavioral: Sleep

Gastrointestinal: Hypermotility, diarrhea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NNGADV 13,401,1988

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWRREVAH 46,1,1973
TOXICOLOGY REVIEWMZUZA8 (8),90,1973
TOXICOLOGY REVIEWDTTIAF 80,485,1973
TOXICOLOGY REVIEWRREVAH 63,1,1976
TOXICOLOGY REVIEWCMSHAF 50,275,2003
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWFEREAC 73,31788,2008
TOXICOLOGY REVIEWJTPAE7 19,1,2006

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,119,1998
Occupational Exposure Limit-AUSTRIATMW 1 mg/m3, 2007
Occupational Exposure Limit-JAPANOccupational Exposure Limit 1 mg/m3, skin, MAY2012
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.02 mg/m3, MAC(short term exposure limit) 0.1 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.1 mg/m3, Skin, JUN2003

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal; Host-mediated assay
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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