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Phosphorothioic acid, S - (2 - (ethylthio) ethyl) O,O - dimethyl ester

RTECS #: TG1750000

CAS #: 919-86-8


UPDATE: February 2009 MW: 230.30 MF: C6H15O3PS2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. BAY 18436
  2. Bayer 25/154
  3. Demeton - S - methyl
  4. Demeton - S - metile (Italian)
  5. Dimethyl S - (2 - eththioethyl) thiophosphate
  6. Ethanethiol, 2 - (ethylthio) - , S - ester with O,O - dimethyl phosphorothioate
  7. Isometasystox
  8. Metaisoseptox
  9. Metaisosystox
  10. Metasystox forte
  11. Metasystox (I)
  12. Metasystox J
  13. Methyl demeton thioester
  14. Methyl isosystox
  15. Methyl thionodemeton
  1. Methyl - mercaptofos teolery
  2. O,O - Dimethyl - S - (2 - aethylthio - aethyl) - monothiophosphat (German)
  3. O,O - Dimethyl S - (2 - eththioethyl) phosphorothioate
  4. O,O - Dimethyl S - ethylmercaptoethyl thiophosphate
  5. O,O - Dimethyl 2 - ethylmercaptoethyl thiophosphate, thiolo isomer
  6. O,O - Dimethyl - S - (2 - ethylthio - ethyl) - monothiofosfaat (Dutch)
  7. O,O - Dimethyl S - (2 - (ethylthio) ethyl) phosphorothioate
  8. O,O - Dimethyl - S - (3 - thia - pentyl) - monothiophosphat (German)
  9. O,O - Dimetil - S - (2 - etiltio - etil) - monotiofosfato (Italian)
  10. Phosphorothioic acid, O,O - dimethyl S - (2 - (ethylthio) ethyl) ester
  11. S - (2 - (Ethylthio) ethyl) dimethyl phosphorothiolate
  12. S - (2 - (Ethylthio) ethyl) O,O - dimethyl phosphorothioate
  13. S - (2 - (Ethylthio) ethyl) O,O - dimethyl thiophosphate
  14. Thiophosphate de O,O - dimethyle et de S - 2 - ethylthio - ethyle (French)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Escherichia coli 5 mg/plate (-enzymatic activation step) MUREAV 28,405,1975
mutation in microorganisms Salmonella typhimurium 5 mg/plate (+enzymatic activation step) MUREAV 28,405,1975
sex chromosome loss and nondisjunction oral
Drosophila melanogaster
80 ppm MUREAV 28,405,1975


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): 500 mg/m3/4 hour N/R 85DPAN -,-,1971/1976
intraperitoneal
guinea pig
lethal dose (50 percent kill): 12,500 g/kg N/R TXAPA9 4,621,1962
intraperitoneal
rat
lethal dose (50 percent kill): 7,500 g/kg N/R TXAPA9 4,621,1962
intravenous
rat
lethal dose (50 percent kill): 65 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases BIJOAK 67,187,1957
oral
guinea pig
lethal dose (50 percent kill): 110 mg/kg N/R TXAPA9 4,621,1962
oral
rat
lethal dose (50 percent kill): 30 mg/kg N/R FMCHA2 -,C197,1991
skin
rat
lethal dose (50 percent kill): 85 mg/kg N/R PHJOAV 185,361,1960
unreported route
mammal (species unspecified)
lethal dose (50 percent kill): 40 mg/kg N/R 30ZDA9 -,346,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 mg/m3 (inhalable, vapor, skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
DTTIAF 80,485,1973
TOXICOLOGY REVIEW
RREVAH 63,1,1976


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - BELGIUM time-weighted average 0.05 mg/m3 (vapor, aerosol), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.05 ppm (0.5 mg/m3), OCT 2002


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE

30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1906-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
PHJOAV Pharmaceutical Journal. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London, SE1 7JN, UK) V.131- 1933-
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used to control aphid vectors of virus diseases, whiteflies, leafhoppers and sawflies

RTECS Compound Description:
   Agricultural Chemical
   Mutagen

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