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Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphorothioic acid, O-(2-(ethylthio)ethyl) O,O-dimethyl ester

RTECS #

TG1650000

CAS #

867-27-6

Updated

April 2012

Molecular Weight

230.30

Molecular Formula

C6H15O3PS2

Synonyms

2-(Ethylthio)ethyl dimethyl phosphorothionate
beta-Ethylmercaptoethyl dimethyl thionophosphate
Demeton-O-methyl
Demeton-O-metile (Italian)
Ethanol, 2-(ethylthio)-, O-ester with O,O-dimethyl phosphorothioate
Methyl-demeton-O
O-(2-(Ethylthio)ethyl) O,O-dimethyl phosphorothioate
O,O-Dimethyl 2-ethylmercaptoethyl thiophosphate, thiono isomer
O,O-Dimethyl O-2-(ethylthio)ethyl phosphorothioate
O,O-Dimethyl O-ethylmercaptoethyl thiophosphate
O,O-Dimethyl-O-(2-aethylthio-aethyl)monothiophosphat (German)
O,O-Dimethyl-O-(2-ethyl-thio-ethyl)-monothiofosfaat (Dutch)
O,O-Dimetil-O-(2-etiltio-etil)-monotiofosfato (Italian)
O-Methyldemeton
Thiophosphate de O,O-dimethyle et de O-2-ethylthio-ethyle (French)

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat Lowest published lethal concentration: 20 mg/m3GISAAA 28(3),21,1963
intravenous/rat lethal dose (50 percent kill): 216 mg/kgBehavioral: Muscle weakness

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation
BIJOAK 67,187,1957
oral/cat lowest published lethal dose: 30 mg/kgFATOAO 22,559,1959
oral/mouse lethal dose (50 percent kill): 46 mg/kgFATOAO 22,559,1959
oral/rat lethal dose (50 percent kill): 75 mg/kgFATOAO 22,559,1959
skin/rabbit lowest published lethal dose: 75 mg/kgBehavioral: TremorFATOAO 22,559,1959

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWRREVAH 46,1,1973
TOXICOLOGY REVIEWMZUZA8 (8),90,1973

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-DENMARKtime-weighted average 0.05 ppm (0.5 mg/m3), skin, MAY2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.05 ppm (0.5 mg/m3), skin, NOV2011
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