Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphorothioic acid, O,O-dimethyl ester, S-ester with 2-((2-mercaptoethyl)thio)-N-methylpropionamide

RTECS #

TF7900000

CAS #

2275-23-2

Updated

February 2009

Molecular Weight

287.36

Molecular Formula

C8H18NO4PS2

Synonyms

American cyanamid-43073
Dimethyl S-(2-(1-methylcarbamoylethylthio)ethyl) phosphorothiolate
ENT 26,613
Kilval
N-Methyl O,O-dimethylthiolophosphoryl-5-thia-3-methyl-2-valeramide
N-Methyl-3-thia-2-methyl-valeramid der O,O-dimethylthiolphosphorsaeure (German)
NPH 83
O,O-Dimethyl S-(2-(1-methylcarbamoylethylthio)ethyl) phosphorothioate
O,O-Dimethyl S-2-(1-N-methylcarbamoylethylmercapto)ethyl thiophosphate
R.P. 10,465
RP-9895
Trucidor
Vamidoate
Vamidothion

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislung/hamster5 mmol/LMUREAV 78,177,1980
DNA repair/Bacillus subtilis25 pphMUREAV 40,19,1976
mutation in microorganisms/Salmonella typhimurium25 pph (+enzymatic activation step)MUREAV 40,19,1976
mutation in microorganisms/Escherichia coli25 pph (-enzymatic activation step)MUREAV 40,19,1976
sister chromatid exchangelung/hamster1 mmol/LMUREAV 78,177,1980

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 1730 mg/m3/4HPEMNDP 9,856,1991
oral/Dog lethal dose (50 percent kill): 110 mg/kgGUCHAZ 6,530,1973
oral/guinea pig lethal dose (50 percent kill): 85 mg/kgGUCHAZ 6,530,1973
oral/mouse lethal dose (50 percent kill): 40 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands
MZUZA8 (8),65,1972
oral/rabbit lethal dose (50 percent kill): 160 mg/kgGTPZAB 14(2),58,1970
oral/rat lethal dose (50 percent kill): 64 mg/kg28ZEAL 5,233,1976
oral/wild bird lethal dose (50 percent kill): 35 mg/kgPEMNDP 9,856,1991
skin/mouse lethal dose (50 percent kill): 1460 mg/kgYKYUA6 37,1621,1986
skin/rabbit lethal dose (50 percent kill): 1160 mg/kgWRPCA2 9,119,1970
unreported route/cat lethal dose (50 percent kill): 117 mg/kgBehavioral: Ataxia

Behavioral: Coma

Kidney, Ureter, and Bladder: Urine volume increased
GISAAA 41(3),107,1976
unreported route/guinea pig lethal dose (50 percent kill): 85 mg/kg30ZDA9 -,349,1971
unreported route/mouse lethal dose (50 percent kill): 43 mg/kg30ZDA9 -,349,1971
unreported route/rat lethal dose (50 percent kill): 64 mg/kg30ZDA9 -,349,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 1020 µg/m3/22W- continuousKidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 30(5),11,1965
oral/mouse lowest published toxic dose: 420 mg/kg/15W- intermittentBrain and Coverings: Changes in circulation

Liver: Hepatitis (hepatocellular necrosis), diffuse

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
MZUZA8 (8),65,1972
oral/rat lowest published toxic dose: 678 mg/kg/17W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
GTPZAB 14(2),58,1970
oral/rat lowest published toxic dose: 375 mg/kg/1Y- intermittentEndocrine: Changes in adrenal weight

Blood: Normocytic anemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 41(3),107,1976

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWRREVAH 63,1,1976
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWJTPAE7 19,1,2006

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: TRP reversion
TOP