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Phosphorothioic acid, O,O - dimethyl ester, S - ester with 2 - ( (2 - mercaptoethyl) thio) - N - methylpropionamide

RTECS #: TF7900000

CAS #: 2275-23-2


UPDATE: February 2009 MW: 287.36 MF: C8H18NO4PS2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. American cyanamid - 43073
  2. Dimethyl S - (2 - (1 - methylcarbamoylethylthio) ethyl) phosphorothiolate
  3. ENT 26,613
  4. Kilval
  5. N - Methyl O,O - dimethylthiolophosphoryl - 5 - thia - 3 - methyl - 2 - valeramide
  6. N - Methyl - 3 - thia - 2 - methyl - valeramid der O,O - dimethylthiolphosphorsaeure (German)
  7. NPH 83
  1. O,O - Dimethyl S - 2 - (1 - N - methylcarbamoylethylmercapto) ethyl thiophosphate
  2. O,O - Dimethyl S - (2 - (1 - methylcarbamoylethylthio) ethyl) phosphorothioate
  3. R.P. 10,465
  4. RP - 9895
  5. Trucidor
  6. Vamidoate
  7. Vamidothion


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster lung 5 mmol/L MUREAV 78,177,1980
DNA repair Bacillus subtilis 25 pph MUREAV 40,19,1976
mutation in microorganisms Escherichia coli 25 pph (-enzymatic activation step) MUREAV 40,19,1976
mutation in microorganisms Salmonella typhimurium 25 pph (+enzymatic activation step) MUREAV 40,19,1976
sister chromatid exchange hamster lung 1 mmol/L MUREAV 78,177,1980


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): 1,730 mg/m3/4 hour N/R PEMNDP 9,856,1991
oral
wild bird
lethal dose (50 percent kill): 35 mg/kg N/R PEMNDP 9,856,1991
oral
dog
lethal dose (50 percent kill): 110 mg/kg N/R GUCHAZ 6,530,1973
oral
guinea pig
lethal dose (50 percent kill): 85 mg/kg N/R GUCHAZ 6,530,1973
oral
mouse
lethal dose (50 percent kill): 40 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands
MZUZA8 (8),65,1972
oral
rat
lethal dose (50 percent kill): 64 mg/kg N/R 28ZEAL 5,233,1976
oral
rabbit
lethal dose (50 percent kill): 160 mg/kg N/R GTPZAB 14(2),58,1970
skin
mouse
lethal dose (50 percent kill): 1,460 mg/kg N/R YKYUA6 37,1621,1986
skin
rabbit
lethal dose (50 percent kill): 1,160 mg/kg N/R WRPCA2 9,119,1970
unreported route
cat
lethal dose (50 percent kill): 117 mg/kg Behavioral: Ataxia

Behavioral: Coma

Kidney, Ureter, and Bladder: Urine volume increased
GISAAA 41(3),107,1976
unreported route
guinea pig
lethal dose (50 percent kill): 85 mg/kg N/R 30ZDA9 -,349,1971
unreported route
mouse
lethal dose (50 percent kill): 43 mg/kg N/R 30ZDA9 -,349,1971
unreported route
rat
lethal dose (50 percent kill): 64 mg/kg N/R 30ZDA9 -,349,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 1,020 g/m3/22 week- continuous Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 30(5),11,1965
oral
mouse
lowest published toxic dose: 420 mg/kg/15 week- intermittent Brain and Coverings: Changes in circulation

Liver: Hepatitis (hepatocellular necrosis), diffuse

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
MZUZA8 (8),65,1972
oral
rat
lowest published toxic dose: 678 mg/kg/17 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
GTPZAB 14(2),58,1970
oral
rat
lowest published toxic dose: 375 mg/kg/1 year- intermittent Endocrine: Changes in adrenal weight

Blood: Normocytic anemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 41(3),107,1976


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
RREVAH 63,1,1976
TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
JTPAE7 19,1,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: TRP reversion


REFERENCES:

CODEN
REFERENCE

28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada)
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
MZUZA8 Meditsinskii Zhurnal Uzbekistana. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1957-
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used as an insecticide and acaricide

RTECS Compound Description:
   Agricultural Chemical
   Mutagen

Click Here for Additional Information about RTECS

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