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Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphorothioic acid, O,O-diethyl S-(2-(ethylthio)ethyl) ester

RTECS #

TF3130000

CAS #

126-75-0

Updated

April 2012

Molecular Weight

258.36

Molecular Formula

C8H19O3PS2

Synonyms

Demeton-S
Diethyl S-(2-ethioethyl)thiophosphate
Ethanethiol, 2-(ethylthio)-, S-ester with O,O-diethyl phosphorothioate
Isodemeton
Isosystox
Izosystox (Czech)
O,O-Diaethyl-S(2-aethylthio-aethyl)-monothiophosphat (German)
O,O-Diethyl S-(2-(ethylthio)ethyl) phosphorothiolate
O,O-Diethyl S-(2-eththioethyl)phosphorothioate
O,O-Diethyl S-2-(ethylthio)ethyl phosphorothioate
O,O-Diethyl S-ethyl-2-ethylmercaptophosphorothiolate
O,O-Diethyl-S-(2-ethylthio-ethyl)-monothiofosfaat (Dutch)
O,O-Dietil-S-(2-etiltio-etil)-monotiofosfato (Italian)
O,O-Dietyl-S-2-etylmerkaptoetyltiofosfat (Czech)
PO-Systox
Thiol systox
Thioldemeton
Thiophosphate de O,O-diethyle et de S-(2-ethylthio-ethyle) (French)

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/guinea pig lethal dose (50 percent kill): 5500 µg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseAMIHAB 13,606,1956
intraperitoneal/mouse lethal dose (50 percent kill): 174 µg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)PHARAT 35,806,1980
intraperitoneal/rat lethal dose (50 percent kill): 1500 µg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseAMIHAB 13,606,1956
intravenous/rat lethal dose (50 percent kill): 1700 µg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseBCPCA6 6,244,1961
oral/mouse lowest published lethal dose: 5800 µg/kgGTPZAB 2(5),7,1958
oral/rat lethal dose (50 percent kill): 1500 µg/kgAEPPAE 217,144,1953
skin/rabbit lowest published lethal dose: 5 mg/kgGTPZAB 2(5),7,1958
subcutaneous/mouse lethal dose (50 percent kill): 6 mg/kgAEPPAE 217,144,1953
unreported route/mouse lethal dose (50 percent kill): 5600 µg/kgGTPZAB 7(5),38,1963

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWENTOX* -,588,2005

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-DENMARKtime-weighted average 0.01 ppm (0.1 mg/m3), skin, MAY2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.01 ppm (0.1 mg/m3), skin, NOV2011

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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