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Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphorodithioic acid, S-(2-(ethylthio)ethyl) O,O-dimethyl ester

RTECS #

TE4375000

CAS #

640-15-3

Updated

October 2012

Molecular Weight

246.36

Molecular Formula

C6H15O2PS3

Synonyms

2-Ethylthioethyl O,O-dimethyl phosphorodithioate
BAY 23129
Bayer 23129
Compound M-81
Dithiometasystox
Dithiomethon
Dithiometon (French)
Dithiophosphate de O,O-dimethyle et de S-(2-ethylthio-ethyle) (French)
Ebicid
Ekatin
Ekatin aerosol
Ekatin ULV
Ekatine-25
Ethanethiol, 2-(ethylthio)-, S-ester with O,O-dimethyl phosphorodithioate
Intrathion
Intration
Luxistelm
M 81
O,O-Dimethyl S-(2-(ethylthio)ethyl) phosphorodithioate
O,O-Dimethyl-S-(2-aethylthio-aethyl)-dithio phosphat (German)
O,O-Dimethyl-S-(2-ethylmercaptoethyl) dithiophosphate
O,O-Dimethyl-S-(2-ethylthio-ethyl)-dithiofosfaat (Dutch)
O,O-Dimethyl-S-2-ethylmerkaptoethylester kyseliny dithiofosforecne (Czech)
O,O-Dimetil-S-(etiltio-etil)-ditiofosfato (Italian)
Phosphorodithioic acid, O,O-dimethyl S-(2-ethylthio)ethyl ester
S-(2-(Ethylthio)ethyl) O,O-dimethylphosphorodithionate
S-(2-(Ethylthio)ethyl)dimethyl phosphorothiolothionate
SAN 230
Thiometon
Veltin

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 750 µg/24H severe85JCAE -,1176,1986
skin /rabbit 500 mg/24H mild85JCAE -,1176,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
micronucleus testintraperitoneal/rat75 mg/kg/5D-continuousMUREAV 188,45,1987
micronucleus testintraperitoneal/mouse100 mg/kgMUREAV 155,131,1985
mutation in microorganisms/Salmonella typhimurium5 mg/plate (+enzymatic activation step)MUREAV 28,405,1975
mutation in microorganisms/Salmonella typhimurium1 mg/plate (-enzymatic activation step)MUREAV 116,185,1983
mutation in microorganisms/Escherichia coli5 mg/plate (-enzymatic activation step)MUREAV 28,405,1975

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat Lowest published lethal concentration: 20 mg/m3/4HBehavioral: Tremor

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea
GTPZAB 4(9),21,1960
inhalation/rat Lowest published lethal concentration: 20 mg/m3/4HBehavioral: Tremor

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea
GTPZAB 4(9),21,1960
intraperitoneal/mouse lethal dose (50 percent kill): 34 mg/kgAEPPAE 236,202,1959
intraperitoneal/rat lethal dose (50 percent kill): 30 mg/kgAEPPAE 236,202,1959
intravenous/rat lethal dose (50 percent kill): 38500 µg/kgEye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement
13ZGAF -,206,1962
oral/mouse lethal dose (50 percent kill): 37 mg/kgBehavioral: Tremor

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea
GTPZAB 4(9),21,1960
oral/rat lethal dose (50 percent kill): 40 mg/kgARZNAD 5,584,1955
skin/rabbit lowest published lethal dose: 100 mg/kg85GMAT -,57,1982
skin/rat lethal dose (50 percent kill): 179 mg/kgEye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement
13ZGAF -,206,1962
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 70 mg/kg30ZDA9 -,368,1971
unreported route/mouse lethal dose (50 percent kill): 36 mg/kgGTPZAB 7(5),38,1963

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 442 mg/kg/78W- intermittentBrain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
FATOBP 8,122,1973
oral/rat lowest published toxic dose: 305 mg/kg/9W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldGTPZAB 4(9),21,1960

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMZUZA8 (8),90,1973
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.1 mg/m3, Skin, JUN2003
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