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Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphorodithioic acid, O,O-dimethyl ester, S-ester with N-(mercaptomethyl)phthalimide

RTECS #

TE2275000

CAS #

732-11-6

Updated

October 2010

Molecular Weight

317.33

Molecular Formula

C11H12NO4PS2

Synonyms

APPA
Decemthion
Decemthion P-6
ENT 25,705
Fosmet
Ftalophos
Imidan
Kemolate
N-(Mercaptomethyl)phthalimide S-(O,O-dimethyl phosphorodithioate)
O,O-Dimethyl 5-(phthalimidomethyl)dithiophosphate
O,O-Dimethyl S-(N-phthalimidomethyl) dithiophosphate
O,O-Dimethyl S-phthalimidomethyl phosphorodithioate
Percolate
Phosmet
Phosphorodithioic acid, S-((1,3-dihydro-1,3-dioxo-isoindol-2-yl)methyl) O,O-dimethyl ester
Phtalofos
Phthalimide, N-(mercaptomethyl)-, S-ester with O,O-dimethyl phosphorodithioate
Phthalimido O,O-dimethyl phosphorodithioate
Phthalimidomethyl O,O-dimethyl phosphorodithioate
Phthalophos
PMP
Prolate
R 1504
Smidan
Stauffer R 1504

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisoral/mouse20 mg/kgSOGEBZ 11,1534,1975
DNA Damagefibroblast/human63466 µg/LEMMUEG 20,73,1992
gene conversion and mitotic recombination/Saccharomyes cerevisiae25000 ppmMUREAV 302,153,1993
morphological transformembryo/hamster7933 µg/LEMMUEG 20,73,1992
mutation in mammalian somatic cellslung/hamster175 mg/LEMMUEG 20,73,1992
mutation in microorganisms/Escherichia coli1000 µg/plate/48HMUTAEX 15,317,2000
mutation in microorganisms/Salmonella typhimurium2000 µg/plate/48HMUTAEX 15,317,2000
mutation in microorganisms/Salmonella typhimurium500 µg/plate (+/-enzymatic activation step)MUREAV 302,153,1993
mutation in microorganisms/Saccharomyes cerevisiae1 pph (-enzymatic activation step)MUREAV 302,153,1993

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 30 mg/kg (8D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemNTIS** PB80-159627
oral/rat 30 mg/kg (13D pregnant)Reproductive: Specific developmental abnormalities: Central nervous systemEVHPAZ 13,121,1976
oral/rat 16500 µg/kg (1-22D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
EVHPAZ 13,121,1976
oral/rat 100 mg/kg (1-20D pregnant)Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on newborn: Stillbirth
VETNAL 56(1),62,1980
oral/rat 6 mg/kg (1-20D pregnant)Reproductive: Maternal effects: ParturitionVETNAL 56(1),62,1980
oral/mouse 49600 µg/kg (1-8D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
AXVMAW 34,791,1980
oral/mouse 6200 µg/kg (12D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)AXVMAW 34,791,1980
oral/mouse 124 mg/kg (1-8D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)AXVMAW 34,791,1980

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat lethal concentration (50 percent kill): 65 mg/m3/4H85GMAT -,59,1982
inhalation/human lowest published toxic concentration: 2 mg/m3/8HOlfaction: Other olfaction effects

Eye: Lacrimation

Behavioral: Somnolence (general depressed activity)
HYSAAV 34(1-3),192,1969
inhalation/rat lethal concentration (50 percent kill): 54 mg/m3/4H85GMAT -,59,1982
oral/chicken lethal dose (50 percent kill): 707 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
TXAPA9 6,147,1964
oral/duck lethal dose (50 percent kill): 1830 mg/kgDOEAAH 35,25,1979
oral/guinea pig lethal dose (50 percent kill): 200 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea
HYSAAV 34(1-3),192,1969
oral/human lowest published lethal dose: 50 mg/kgSPEADM 74-1,-,1974
oral/mouse lethal dose (50 percent kill): 26 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea
HYSAAV 34(1-3),192,1969
oral/rat lethal dose (50 percent kill): 92500 µg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
GISAAA 34(2),30,1969
oral/wild bird lethal dose (50 percent kill): 18 mg/kgTXAPA9 21,315,1972
skin/rabbit lethal dose (50 percent kill): >3160 mg/kg85JFAN A325,1983
skin/rat lethal dose (50 percent kill): 1326 mg/kg85GMAT -,59,1982
unreported route/cat lethal dose (50 percent kill): 78 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseGISAAA 35(12),94,1970
unreported route/guinea pig lethal dose (50 percent kill): 210 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseGISAAA 35(12),94,1970
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 40 mg/kg30ZDA9 -,370,1971
unreported route/mouse lethal dose (50 percent kill): 37500 µg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseGISAAA 35(12),94,1970
unreported route/rat lethal dose (50 percent kill): 132 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseGISAAA 35(12),94,1970

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/cat lowest published toxic concentration: 18 mg/m3/35D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
GISAAA 34(2),30,1969
inhalation/rat lowest published toxic concentration: 16 mg/m3/35D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseGISAAA 34(2),30,1969
skin/rabbit lowest published toxic dose: 4500 mg/kg/21D- intermittentLung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0545680
unreported route/cat lowest published toxic dose: 273 mg/kg/30W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 35(12),94,1970

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWRREVAH 46,1,1973
TOXICOLOGY REVIEWTOLED5 142,207,2003
TOXICOLOGY REVIEWENTOX* -,306,2005
TOXICOLOGY REVIEWJTPAE7 19,1,2006
TOXICOLOGY REVIEWFEREAC 73,80317,2008
TOXICOLOGY REVIEWFEREAC 73,47186,2008
TOXICOLOGY REVIEWFCTOD7 47,2906,2009
TOXICOLOGY REVIEWFEREAC 74,46689,2009

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,142,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.3 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X1561; Number of Industries 1; Total Number of Facilities 230; Number of Occupations 1; Total Number of Employees Exposed 1838; Total Number of Female Employees Exposed 1608

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9097
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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