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Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphorodithioic acid, O,O-dimethyl ester, S-ester with 4-(mercaptomethyl)-2-methoxy-delta(sup 2)-1,3,4-thiadiazolin-5-one

RTECS #

TE2100000

CAS #

950-37-8

Updated

July 2011

Molecular Weight

302.34

Molecular Formula

C6H11N2O4PS3

Synonyms

Ciba-Geigy GS 13005
DMTP (insecticide)
ENT 27193
Fisons NC 2964
Geigy 13005
Geigy GS-13005
GS 13005
Methidathion
Methidathion 50S
Metidation (Polish)
O,O-Dimethyl S-(2,3-dihydro-5-methoxy-2-oxo-1,3,4-thiadiazol-3-ylmethyl) phosphorodithioate
O,O-Dimethyl S-(5-methoxy-1,3,4-thiadiazolinyl-3-methyl) dithiophosphate
O,O-Dimethyl-S-((2-methoxy-1,3,4 (4H)-thiodiazol-5-on-4-yl)-methyl)-dithiofosfaat (Dutch)
O,O-Dimethyl-S-(2-methoxy-1,3,4-thiadiazol-5(4H)-onyl-(4)-methyl) phosphorodithioate
O,O-Dimethyl-S-(2-methoxy-1,3,4-thiadiazol-5-(4H)-onyl-(4)-methyl)-dithiophosphat (German)
O,O-Dimethyl-S-(2-methoxy-1,3,4-thiadiazol-5-on-4-yl)-methyl-dithiophosphat (German)
O,O-Dimetil-S-((2-metossi-1,3,4-(4H)-tiadiazol-5-on-4-il)-metil)-ditifosfato (Italian)
OMS 844
S-((2-Methoxy-5-oxo-1,3,4-thia-diazolin-4-yl)methyl)dimethylphosphorothiolothionate
S-((5-Methoxy-2-oxo-1,3,4-thiadiazol-3(2H)-yl)methyl) O,O-dimethyl phosphorodithioate
S-(2,3-Dihydro-5-methoxy-2-oxo-1,3,4-thiadiazol-3-methyl) dimethyl phosphorothiolothionate
S-2-Metoksy-1,3,4-tiadiazolo-5-on-N-metylo-O,O-dwumetylowy (Polish)
Somonil
Supracid
Supracide
Ultracid 40
Ultracid EC 40

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 24400 µg severeCIGET*

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
sister chromatid exchangelung/hamster40 mg/LMUREAV 88,307,1981

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 50 mg/m3/4HCIGET*
oral/chicken lethal dose (50 percent kill): 80 mg/kg85JFAN A268,1983
oral/guinea pig lethal dose (50 percent kill): 25 mg/kg85JFAN A268,1983
oral/mammal (species unspecified) lethal dose (50 percent kill): 25 mg/kgHPBIA9 21,53,1975
oral/man lowest published toxic dose: 93 mg/kgEye: Miosis (pupilliary constriction)

Eye: Lacrimation

Behavioral: Coma
HETOEA 9,415,1990
oral/mouse lethal dose (50 percent kill): 25 mg/kgBESAAT 15,122,1969
oral/rabbit lethal dose (50 percent kill): 63 mg/kg85JFAN A268,1983
oral/rat lethal dose (50 percent kill): 20 mg/kgWRPCA2 9,119,1970
oral/rat lowest published toxic dose: 5 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor
HETOEA 23,323,2004
oral/rat lowest published toxic dose: 5 mg/kgPeripheral Nerve and Sensation: Fasciculations

Behavioral: Tremor
HETOEA 26,491,2007
skin/rabbit lethal dose (50 percent kill): 196 mg/kgCIGET*
skin/rat lethal dose (50 percent kill): 25 mg/kgWRPCA2 9,119,1970
Tank with water/Carp lowest published toxic concentration: 2 mg/L/5DBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTIVIEQ 33,279,1995
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 25 mg/kg30ZDA9 -,372,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 17155 mg/kg/1Y- intermittentLiver: Jaundice, cholestatic

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
FAATDF 19,307,1992
oral/rat lowest published toxic dose: 7 mg/kg/14D- continuousImmunological Including Allergic: Decrease in humoral immune response

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOLED5 135,S156,2002
oral/rat lowest published toxic dose: 100 mg/kg/4W- intermittentVascular: Structural changes in vessels

Biochemical: Metabolism (intermediary): Lipids including transport
ARTODN 78,655,2004
oral/rat lowest published toxic dose: 100 mg/kg/28D- intermittentCardiac: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Metabolism (intermediary): Other
HETOEA 23,323,2004
oral/rat lowest published toxic dose: 100 mg/kg/4W- continuousReproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Menstrual cycle changes or disorders

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Reactivates cholinesterase
HETOEA 26,491,2007
oral/rat lowest published toxic dose: 225 mg/kg/9W- intermittentEndocrine: Changes in spleen weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
RPZHAW 20,463,1969

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWRREVAH 46,1,1973
TOXICOLOGY REVIEWRREVAH 63,1,1976
TOXICOLOGY REVIEWMUREAV 557,109,2004
TOXICOLOGY REVIEWTOLED5 127,29,2002
TOXICOLOGY REVIEWMUREAV 588,129,2005
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWFEREAC 72,53455,2007
TOXICOLOGY REVIEWJTPAE7 19,1,2006
TOXICOLOGY REVIEWFCTOD7 47,2906,2009

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,130,1998

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X2166; Number of Industries 1; Total Number of Facilities 13; Number of Occupations 1; Total Number of Employees Exposed 26

Status in Federal Agencies

OrganizationReference
On EPA IRIS database
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