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Phosphorodithioic acid, O,O - dimethyl ester, S - ester with 4 - (mercaptomethyl) - 2 - methoxy - delta (sup 2) - 1,3,4 - thiadiazolin - 5 - one

RTECS #: TE2100000

CAS #: 950-37-8


UPDATE: February 2009 MW: 302.34 MF: C6H11N2O4PS3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Ciba - Geigy GS 13005
  2. DMTP (insecticide)
  3. ENT 27193
  4. Fisons NC 2964
  5. GS 13005
  6. Geigy 13005
  7. Geigy GS - 13005
  8. Methidathion
  9. Methidathion 50S
  10. Metidation (Polish)
  11. O,O - Dimethyl S - (2,3 - dihydro - 5 - methoxy - 2 - oxo - 1,3,4 - thiadiazol - 3 - ylmethyl) phosphorodithioate
  12. O,O - Dimethyl S - (5 - methoxy - 1,3,4 - thiadiazolinyl - 3 - methyl) dithiophosphate
  13. O,O - Dimethyl - S - (2 - methoxy - 1,3,4 - thiadiazol - 5 - on - 4 - yl) - methyl - dithiophosphat (German)
  14. O,O - Dimethyl - S - (2 - methoxy - 1,3,4 - thiadiazol - 5 - (4H) - onyl - (4) - methyl) - dithiophosphat (German)
  1. O,O - Dimethyl - S - (2 - methoxy - 1,3,4 - thiadiazol - 5 (4H) - onyl - (4) - methyl) phosphorodithioate
  2. O,O - Dimethyl - S - ( (2 - methoxy - 1,3,4 (4H) - thiodiazol - 5 - on - 4 - yl) - methyl) - dithiofosfaat (Dutch)
  3. O,O - Dimetil - S - ( (2 - metossi - 1,3,4 - (4H) - tiadiazol - 5 - on - 4 - il) - metil) - ditifosfato (Italian)
  4. OMS 844
  5. S - ( (2 - Methoxy - 5 - oxo - 1,3,4 - thia - diazolin - 4 - yl) methyl) dimethylphosphorothiolothionate
  6. S - ( (5 - Methoxy - 2 - oxo - 1,3,4 - thiadiazol - 3 (2H) - yl) methyl) O,O - dimethyl phosphorodithioate
  7. S - (2,3 - Dihydro - 5 - methoxy - 2 - oxo - 1,3,4 - thiadiazol - 3 - methyl) dimethyl phosphorothiolothionate
  8. S - 2 - Metoksy - 1,3,4 - tiadiazolo - 5 - on - N - metylo - O,O - dwumetylowy (Polish)
  9. Somonil
  10. Supracid
  11. Supracide
  12. Ultracid 40
  13. Ultracid EC 40


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
24,400 g severe CIGET*


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
sister chromatid exchange hamster lung 40 mg/L MUREAV 88,307,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): 50 mg/m3/4 hour N/R CIGET*
oral
chicken
lethal dose (50 percent kill): 80 mg/kg N/R 85JFAN A268,1983
oral
guinea pig
lethal dose (50 percent kill): 25 mg/kg N/R 85JFAN A268,1983
oral
mammal (species unspecified)
lethal dose (50 percent kill): 25 mg/kg N/R HPBIA9 21,53,1975
oral
man
lowest published toxic dose: 93 mg/kg Eye: Miosis (pupilliary constriction)

Eye: Lacrimation

Behavioral: Coma
HETOEA 9,415,1990
oral
mouse
lethal dose (50 percent kill): 25 mg/kg N/R BESAAT 15,122,1969
oral
rat
lethal dose (50 percent kill): 20 mg/kg N/R WRPCA2 9,119,1970
oral
rat
lowest published toxic dose: 5 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor
HETOEA 23,323,2004
oral
rabbit
lethal dose (50 percent kill): 63 mg/kg N/R 85JFAN A268,1983
skin
rat
lethal dose (50 percent kill): 25 mg/kg N/R WRPCA2 9,119,1970
skin
rabbit
lethal dose (50 percent kill): 196 mg/kg N/R CIGET*
unreported route
mammal (species unspecified)
lethal dose (50 percent kill): 25 mg/kg N/R 30ZDA9 -,372,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
dog
lowest published toxic dose: 17,155 mg/kg/1 year- intermittent Liver: Jaundice, cholestatic

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
FAATDF 19,307,1992
oral
rat
lowest published toxic dose: 225 mg/kg/9 week- intermittent Endocrine: Changes in spleen weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
RPZHAW 20,463,1969
oral
rat
lowest published toxic dose: 7 mg/kg/14 day- continuous Immunological Including Allergic: Decrease in humoral immune response

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOLED5 135,S156,2002
oral
rat
lowest published toxic dose: 100 mg/kg/4 week- intermittent Vascular: Structural changes in vessels

Biochemical: Metabolism (intermediary): Lipids including transport
ARTODN 78,655,2004
oral
rat
lowest published toxic dose: 100 mg/kg/28 day- intermittent Cardiac: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Metabolism (intermediary): Other
HETOEA 23,323,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
RREVAH 46,1,1973
TOXICOLOGY REVIEW
RREVAH 63,1,1976
TOXICOLOGY REVIEW
MUREAV 557,109,2004
TOXICOLOGY REVIEW
TOLED5 127,29,2002
TOXICOLOGY REVIEW
MUREAV 588,129,2005
TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
FEREAC 72,53455,2007
TOXICOLOGY REVIEW
FEREAC 72,53455,2007
TOXICOLOGY REVIEW
JTPAE7 19,1,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,130,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X2166;
Number of Industries 1;
Total Number of Facilities 13;
Number of Occupations 1;
Total Number of Employees Exposed 26


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

On EPA IRIS database


REFERENCES:

CODEN
REFERENCE

30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BESAAT Bulletin of the Entomological Society of America. (Entomological Soc. of America, 4603 Calvert Rd., College Park, MD 20740) V.1- 1955-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
HPBIA9 Herba Polonica. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.11- 1965-
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RPZHAW Roczniki Panstwowego Zakladu Higieny. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950-
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

Used as an insecticide on fruits, tobacco, forage, cotton and vegetables

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Human Data
   Primary Irritant

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