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Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphorodithioic acid, O,O-dimethyl ester, S-ester with 2-mercapto-N-methylacetamide

RTECS #

TE1750000

CAS #

60-51-5; 11096-20-1; 56833-73-9

Updated

December 2013

Molecular Weight

229.27

Molecular Formula

C5H12NO3PS2

Synonyms

8014 Bis HC
Aadimethoal
AC-12880
AC-18682
Acetic acid, O,O-dimethyldithiophosphoryl-, N-monomethylamide salt
American cyanamid 12880
BI 58 EC
BI-58
Cekuthoate
CL 12880
Cygon
Cygon 2-E
Cygon 400
Cygon 4E
Cygon insecticide
Daphene
De-fend
Demos-L40
Devigon
Dimate 267
Dimetate
Dimethoaat (Dutch)
Dimethoat (German)
Dimethoate
Dimethogen
Dimeton
Dimevur
Dithiophosphate de O,O-dimethyle et de S(-N-methylcarbamoyl-methyle) (French)
EI-12880
ENT 24,650
Experimental insecticide 12,880
Ferkethion
FIP
Fortion NM
Fosfamid
Fosfotox
Fosfotox R
Fosfotox R 35
Fostion MM
L-395
Lurgo
NCI-C00135
O,O-Dimethyl methylcarbamoylmethyl phosphorodithioate
O,O-Dimethyl S-(2-(methylamino)-2-oxoethyl) phosphorodithioate
O,O-Dimethyl S-(N-methylcarbamoylmethyl) dithiophosphate
O,O-Dimethyl S-(N-methylcarbamoylmethyl) phosphorodithioate
O,O-Dimethyl S-(N-methylcarbamylmethyl) thiothionophosphate
O,O-Dimethyldithiophosphorylacetic acid, N-monomethylamide salt
O,O-Dimethyl-dithiophosphorylessigsaeure monomethylamid (German)
O,O-Dimethyl-S-(2-oxo-3-aza-butyl)-dithiophosphat (German)
O,O-Dimethyl-S-(N-monomethyl)-carbamyl methyl dithiophosphate
O,O-Dimetil-S-(N-metil-carbamoil-metil)-ditiofosfato (Italian)
OMS 94
PEI 75
Perfekthion
Phosphamid
Phosphamide
Phosphorodithioic acid, O,O-dimethyl-S-(2-(methylamino)-2-oxoethyl) ester (9CI)
Racusan
RCRA waste number P044
Rebelate
Rogodan
Rogor
Rogor 20L
Rogor 40
Rogor L
Rogor P
Roxion
Salut
Sevigor
Sinoratox
Sistemin
S-Methylcarbamoylmethyl O,O-dimethyl phosphorodithioate
Systemin
Systoate
Tara
Tara 909

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
body fluid assaySalmonella typhimurium/rat50600 µg/kgIJEBA6 24,305,1986
Cytogenetic Analysisintraperitoneal/rat19 mg/kgNULSAK 33,14,1990
Cytogenetic Analysisintraperitoneal/mouse60 mg/kgMUREAV 97,207,1982
Cytogenetic Analysisparenteral/mouse50 mg/kgCUSCAM 44,859,1975
Cytogenetic Analysisoral/mouse1376 µg/kg/10D-continuousMUREAV 299,29,1993
Cytogenetic Analysisintraperitoneal/hamster16 mg/kgARTODN 58,152,1986
Cytogenetic Analysislung/hamster390 mg/LGMCRDC 27,95,1981
Cytogenetic Analysislymphocyte/other fish1 mmol/LENMUDM 8,555,1986
Cytogenetic Analysislymphocyte/human44 µmol/LSOGEBZ 10,1580,1974
DNA repair/Other microorganisms10 mg/plateBIZNAT 95,463,1976
gene conversion and mitotic recombination/Saccharomyes cerevisiae66 mmol/L/27HIARCCD 10,161,1974
host-mediated assaySalmonella typhimurium/mouse465 mg/kg/3D-continuousBECTA6 25,277,1980
micronucleus testoral/mouse103 mg/kg/24HBECTA6 25,277,1980
micronucleus testintraperitoneal/rat47500 µg/kgNULSAK 33,14,1990
micronucleus testlymphocyte/human10 mg/LMUREAV 388,27,1997
mutation in microorganisms/Saccharomyes cerevisiae10 gm/L (+/-enzymatic activation step)MUREAV 321,203,1994
mutation in microorganisms/Salmonella typhimurium5 µg/plate (+enzymatic activation step)IJEBA6 24,305,1986
mutation in microorganisms/Salmonella typhimurium500 µg/plate (-enzymatic activation step)JTEHD6 16,403,1985
mutation in microorganisms/Escherichia coli1 mmol/L/4H (-enzymatic activation step)MUREAV 20,7,1973
mutation in microorganisms/Other microorganisms100 mg/L (-enzymatic activation step)CYGEDX 15(3),64,1981
other mutation test systemsoral/mouse1376 µg/kg/10D-continuousMUREAV 299,29,1993
sex chromosome loss and nondisjunctionparenteral/Drosophila melanogaster10 ppmMUREAV 172,237,1986
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster75 ppb/96HMUREAV 206,351,1988
sister chromatid exchangelymphocyte/other fish300 µmol/LENMUDM 8,555,1986
sister chromatid exchangelymphocyte/human2 mg/LMUREAV 102,89,1982
sister chromatid exchangeembryo/human229 mg/LSNSHBT (20),574,1980
sister chromatid exchangelung/hamster20 mg/LENMUDM 4,621,1982
specific locus testoral/Drosophila melanogaster75 ppb/96HMUREAV 206,351,1988
Unscheduled DNA Synthesisfibroblast/human100 µmol/LMUREAV 42,161,1977
Unscheduled DNA Synthesisintraperitoneal/mouse80 mg/kgAPTOA6 55,104,1984

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse 40 mg/kg (1D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathBIRUAA 13,238,1975
oral/cat 108 mg/kg (14-22D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemJEPTDQ 2(6),1283,1979
oral/rat 150 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
BDERB* 77,40,2006
oral/rat 150 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathBDERB* 77,40,2006
oral/mouse 300 mg/kg (4W male)Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)REPTED 23,232,2007
oral/mouse 560 mg/kg (4W male)Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)
REPTED 23,232,2007
oral/mouse 560 mg/kg (4W male)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
REPTED 23,232,2007
oral/rat 120 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemBECTA6 22,522,1979
oral/rat 113 mg/kg (6-20D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects to embryo or fetus
IJEBA6 34,329,1996
oral/mouse 1050 mg/kg (multigenerations)Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
TXAPA9 26,29,1973
oral/mouse 220 mg/kg (6-16D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)JPFCD2 20,373,1985
oral/mouse 440 mg/kg (6-16D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemJPFCD2 20,373,1985

Tumorigenic Data and References

Route/OrganismDoseEffectReference
intramuscular/rat lowest published toxic dose: 176 mg/kg/6W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Tumors
ARGEAR 41,311,1973
oral/rat lowest published toxic dose: 256 mg/kg/4W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Tumors
ARGEAR 41,311,1973

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/guinea pig lethal dose (10 percent kill): 390 mg/kgTXAPA9 8,259,1966
intraperitoneal/hamster lethal dose (50 percent kill): 160 mg/kgARTODN 58,152,1986
intraperitoneal/mouse lowest published toxic dose: 50 mg/kgBehavioral: Change in motor activity (specific assay)BECTA6 70,138,2003
intraperitoneal/mouse lowest published toxic dose: 100 mg/kgBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases
TXAPA9 224,98,2007
intraperitoneal/mouse lethal dose (50 percent kill): 45 mg/kgEye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
BJIMAG 21,52,1964
intraperitoneal/mouse lowest published toxic dose: 20 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseNRTXDN 33,105,2012
intraperitoneal/rat lethal dose (50 percent kill): 100 mg/kgEye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
BJIMAG 21,52,1964
intraperitoneal/rat lowest published toxic dose: 49.98 ng/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
TXCYAC 253,8,2008
intraperitoneal/rat lowest published toxic dose: 350 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Blood: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TXCYAC 211,149,2005
intravenous/rat lethal dose (50 percent kill): 450 mg/kgEye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
BJIMAG 21,52,1964
oral/cat lethal dose (50 percent kill): 100 mg/kgBehavioral: ExcitementGISAAA 28(3),21,1963
oral/chicken lethal dose (50 percent kill): 25 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseJAFCAU 11,91,1963
oral/Dog lethal dose (50 percent kill): 400 mg/kgSPEADM 78-1,31,1978
oral/duck lethal dose (50 percent kill): 42 mg/kgDOEAAH 35,25,1979
oral/guinea pig lethal dose (50 percent kill): 350 mg/kgPCOC** -,395,1966
oral/hamster lethal dose (50 percent kill): 200 mg/kgEye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
BJIMAG 21,52,1964
oral/human lethal dose (50 percent kill): 30 mg/kgGUCHAZ 6,209,1973
oral/man lowest published toxic dose: 300 mg/kgBehavioral: Coma

Cardiac: Pulse rate decreased with fall in BP

Vascular: BP lowering not characterized in autonomic section
JTCTDW 24,69,1986
oral/man lowest published toxic dose: 357 mg/kgBrain and Coverings: Other degenerative changes

Cardiac: Cardiomyopathy including infarction

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
JTCTDW 32,61,1994
oral/man lowest published toxic dose: 286 mg/kgPeripheral Nerve and Sensation: Fasciculations

Behavioral: Coma

Lung, Thorax, or Respiration: Dyspnea
ICMED9 12,110,1986
oral/man lowest published toxic dose: 179 mg/kgBehavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
HETOEA 22,107,2003
oral/mouse lethal dose (50 percent kill): 60 mg/kgEye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
BJIMAG 21,52,1964
oral/quail lethal dose (50 percent kill): 25 mg/kgJAFCAU 29,772,1981
oral/rabbit lethal dose (50 percent kill): 300 mg/kgSPEADM 78-1,31,1978
oral/rat lethal dose (50 percent kill): 60 mg/kgYKYUA6 30,623,1979
oral/rat lowest published toxic dose: 5 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTOSCF2 92,235,2006
oral/rat lowest published toxic dose: 75 mg/kgBehavioral: Ataxia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOSCF2 92,235,2006
oral/wild bird lethal dose (50 percent kill): 6600 µg/kgTXAPA9 21,315,1972
oral/woman lowest published toxic dose: 1.76 gm/kgBehavioral: Coma

Endocrine: Evidence of thyroid hyperfunction

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
AJEMEN 25,861.e1,2007
skin/guinea pig lethal dose (50 percent kill): 965 mg/kgTXAPA9 3,210,1961
skin/mouse lethal dose (50 percent kill): 1 gm/kgGISAAA 33(6),6,1968
skin/rabbit lethal dose (50 percent kill): 1 gm/kgBehavioral: ExcitementGISAAA 28(3),21,1963
skin/rat lethal dose (50 percent kill): 353 mg/kgBJIMAG 26,59,1969
subcutaneous/hamster lethal dose (50 percent kill): 60 mg/kgEye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
BJIMAG 21,52,1964
subcutaneous/mouse lethal dose (50 percent kill): 60 mg/kgEye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
BJIMAG 21,52,1964
subcutaneous/rat lethal dose (50 percent kill): 350 mg/kgEye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
BJIMAG 21,52,1964
Tank with water/Shrimp lethal concentration (50 percent kill): 800 µg/L/96HEESADV 73,360,2010
unreported route/mouse lethal dose (50 percent kill): 158 mg/kgRISHDJ 23,101,1983
unreported route/rat lethal dose (50 percent kill): 215 mg/kgYKYUA6 28,225,1977

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 4500 µg/m3/8H/13W- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 33(6),6,1968
inhalation/rat lowest published toxic concentration: 4500 µg/m3/13W- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 33(6),6,1968
inhalation/rat lowest published toxic concentration: 257 µg/m3/24H/15W- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 41(9),7,1976
intraperitoneal/mouse lowest published toxic dose: 60 mg/kg/30D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
TOLED5 91,1,1997
intraperitoneal/mouse lowest published toxic dose: 120 mg/kg/30D- intermittentEndocrine: Evidence of thyroid hyperfunction

Biochemical: Metabolism (intermediary): Other
TOLED5 91,1,1997
intraperitoneal/mouse lowest published toxic dose: 65 mg/kg/13D- intermittentBehavioral: Alteration of classical conditioningNRTXDN 33,105,2012
intraperitoneal/mouse lowest published toxic dose: 10 mg/kg/2D- intermittentBehavioral: AtaxiaNRTXDN 33,105,2012
oral/chicken lowest published toxic dose: 56 mg/kg/4W- intermittentLiver: Other changes

Endocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
BECTA6 57,335,1996
oral/Dog lowest published toxic dose: 3937 mg/kg/90D- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTXAPA9 3,210,1961
oral/mouse lowest published toxic dose: 560 mg/kg/4W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainREPTED 23,232,2007
oral/mouse lowest published toxic dose: 300 mg/kg/4W- intermittentRelated to Chronic Data: Changes in testicular weightREPTED 23,232,2007
oral/rat lowest published toxic dose: 280 mg/kg/1W- intermittentEndocrine: HyperglycemiaPCBPBS 90,58,2008
oral/rat lowest published toxic dose: 2240 mg/kg/8W- intermittentGastrointestinal: Changes in structure or function of exocrine pancreas

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
PCBPBS 90,58,2008
oral/rat lowest published toxic dose: 400 mg/kg/10D- continuousKidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Kidney, Ureter, and Bladder: Changes in kidney weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
PCBPBS 91,96,2008
oral/rat lowest published toxic dose: 10752 mg/kg/80W- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldENVRAL 34,193,1984
oral/rat lowest published toxic dose: 5208 mg/kg/80W- continuousKidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Blood: Leukemia

Reproductive: Paternal effects: Testes, epididymis, sperm duct
ENVRAL 34,193,1984
oral/rat lowest published toxic dose: 5376 mg/kg/80W- continuousBlood: LeukemiaENVRAL 34,193,1984
oral/rat lowest published toxic dose: 1260 mg/kg/60D- intermittentGastrointestinal: Changes in structure or function of exocrine pancreas

Endocrine: Hyperglycemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
TOLED5 133,161,2002
oral/rat lowest published toxic dose: 180 mg/kg/30D- intermittentBrain and Coverings: Other degenerative changes

Liver: Hepatitis (hepatocellular necrosis), zonal

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXCYAC 215,173,2005
oral/rat lowest published toxic dose: 600 mg/kg/30D- intermittentGastrointestinal: Changes in structure or function of exocrine pancreas

Gastrointestinal: Changes in pancreatic weight

Endocrine: Hyperglycemia
TXCYAC 231,137,2007
oral/rat lowest published toxic dose: 1200 mg/kg/30D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXCYAC 231,137,2007
oral/rat lowest published toxic dose: 75 mg/kg/5D- intermittentBehavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Hypermotility, diarrhea
BDERB* 77,40,2006
oral/rat lowest published toxic dose: 150 mg/kg/10D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseBDERB* 77,40,2006
oral/rat lowest published toxic dose: 112 mg/kg/4D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainBDERB* 77,40,2006
oral/rat lowest published toxic dose: 196 mg/kg/7D- intermittentBehavioral: Food intake (animal)BDERB* 77,40,2006
oral/rat lowest published toxic dose: 3852 mg/kg/26W- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli
JDGRAX 21,225,1994
oral/rat lowest published toxic dose: 500 mg/kg/5D- intermittentSkin: After systemic exposure: Dermatitis, otherTOXID9 54,334,2000
oral/rat lowest published toxic dose: 630 mg/kg/28D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
IJEBA6 30,394,1992
oral/rat lowest published toxic dose: 1092 mg/kg/52W- continuousBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
BJIMAG 21,52,1964
oral/rat lowest published toxic dose: 300 mg/kg/6W- intermittentBrain and Coverings: Changes in surface EEG

Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NETEEC 10,429,1988
oral/rat lowest published toxic dose: 3330 mg/kg/90D- continuousEye: Other eye effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXAPA9 3,210,1961

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWAQMOAC #73-19,1973
TOXICOLOGY REVIEWRREVAH 46,1,1973
TOXICOLOGY REVIEWMZUZA8 (8),90,1973
TOXICOLOGY REVIEWDTTIAF 80,485,1973
TOXICOLOGY REVIEWRREVAH 63,1,1976
TOXICOLOGY REVIEWENVRAL 34,193,1984
TOXICOLOGY REVIEWNULSAK 28,243,1985
TOXICOLOGY REVIEWTOLED5 128,45,2002
TOXICOLOGY REVIEWMUREAV 562,77,2004
TOXICOLOGY REVIEWMUREAV 567,109,2004
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWENTOX* -,47,2005
TOXICOLOGY REVIEWEJPHAZ 553,10,2006
TOXICOLOGY REVIEWENTOX* -,306,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWFEREAC 73,6867,2008
TOXICOLOGY REVIEWMUREAV 654,114,2008
TOXICOLOGY REVIEWJTPAE7 19,1,2006
TOXICOLOGY REVIEWMUREAV 543,251,2003
TOXICOLOGY REVIEWHTOPA* 1,501,2002
TOXICOLOGY REVIEWFEREAC 73,53732,2008
TOXICOLOGY REVIEWHETOEA 26,321,2007
TOXICOLOGY REVIEWFCTOD7 47,2906,2009
TOXICOLOGY REVIEWMUTAEX 23,271,2008
TOXICOLOGY REVIEWNTAPM* -,629,1995
TOXICOLOGY REVIEWMUTAEX 26,19,2011
TOXICOLOGY REVIEWTOLED5 190,107,2009
TOXICOLOGY REVIEWMUTAEX 21,343,2006
TOXICOLOGY REVIEWMUREAV 721,27,2011
TOXICOLOGY REVIEWREPTED 33,269,2012

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,113,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.5 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84534; Number of Industries 1; Total Number of Facilities 54; Number of Occupations 1; Total Number of Employees Exposed 1665; Total Number of Female Employees Exposed 107
National Occupational Hazard Survey 1974Hazard Code 84534; Number of Industries 2; Total Number of Facilities 30; Number of Occupations 2; Total Number of Employees Exposed 90

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,ratNCITR* NCI-TR-4,1977
On EPA IRIS database
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