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Phosphorodithioic acid, O,O - dimethyl ester, S - ester with 2 - mercapto - N - methylacetamide

RTECS #: TE1750000

CAS #: 60-51-5


UPDATE: May 2009 MW: 229.27 MF: C5H12NO3PS2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 8014 Bis HC
  2. AC - 12880
  3. AC - 18682
  4. Aadimethoal
  5. Acetic acid, O,O - dimethyldithiophosphoryl - , N - monomethylamide salt
  6. American cyanamid 12880
  7. BI 58 EC
  8. BI - 58
  9. CL 12880
  10. Cekuthoate
  11. Cygon
  12. Cygon 2 - E
  13. Cygon 400
  14. Cygon 4E
  15. Cygon insecticide
  16. Daphene
  17. De - fend
  18. Demos - L40
  19. Devigon
  20. Dimate 267
  21. Dimetate
  22. Dimethoaat (Dutch)
  23. Dimethoat (German)
  24. Dimethoate
  25. Dimethogen
  26. Dimeton
  27. Dimevur
  28. Dithiophosphate de O,O - dimethyle et de S ( - N - methylcarbamoyl - methyle) (French)
  29. EI - 12880
  30. ENT 24,650
  31. Experimental insecticide 12,880
  32. FIP
  33. Ferkethion
  34. Fortion NM
  35. Fosfamid
  36. Fosfotox
  37. Fosfotox R
  38. Fosfotox R 35
  39. Fostion MM
  1. L - 395
  2. Lurgo
  3. NCI - C00135
  4. O,O - Dimethyldithiophosphorylacetic acid, N - monomethylamide salt
  5. O,O - Dimethyl - dithiophosphorylessigsaeure monomethylamid (German)
  6. O,O - Dimethyl S - (2 - (methylamino) - 2 - oxoethyl) phosphorodithioate
  7. O,O - Dimethyl S - (N - methylcarbamoylmethyl) dithiophosphate
  8. O,O - Dimethyl methylcarbamoylmethyl phosphorodithioate
  9. O,O - Dimethyl S - (N - methylcarbamoylmethyl) phosphorodithioate
  10. O,O - Dimethyl S - (N - methylcarbamylmethyl) thiothionophosphate
  11. O,O - Dimethyl - S - (N - monomethyl) - carbamyl methyl dithiophosphate
  12. O,O - Dimethyl - S - (2 - oxo - 3 - aza - butyl) - dithiophosphat (German)
  13. O,O - Dimetil - S - (N - metil - carbamoil - metil) - ditiofosfato (Italian)
  14. OMS 94
  15. PEI 75
  16. Perfekthion
  17. Phosphamide
  18. Phosphamid
  19. Phosphorodithioic acid, O,O - dimethyl - S - (2 - (methylamino) - 2 - oxoethyl) ester (9CI)
  20. RCRA waste number P044
  21. Racusan
  22. Rebelate
  23. Rogodan
  24. Rogor
  25. Rogor 20L
  26. Rogor 40
  27. Rogor L
  28. Rogor P
  29. Roxion
  30. S - Methylcarbamoylmethyl O,O - dimethyl phosphorodithioate
  31. Salut
  32. Sevigor
  33. Sinoratox
  34. Sistemin
  35. Systemin
  36. Systoate
  37. Tara
  38. Tara 909


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
body fluid assay rat
Salmonella typhimurium
50,600 g/kg IJEBA6 24,305,1986
cytogenetic analysis intraperitoneal
hamster
16 mg/kg ARTODN 58,152,1986
cytogenetic analysis hamster lung 390 mg/L GMCRDC 27,95,1981
cytogenetic analysis human lymphocyte 44 mol/L SOGEBZ 10,1580,1974
cytogenetic analysis intraperitoneal
mouse
60 mg/kg MUREAV 97,207,1982
cytogenetic analysis parenteral
mouse
50 mg/kg CUSCAM 44,859,1975
cytogenetic analysis oral
mouse
1,376 g/kg/10 day- continuous MUREAV 299,29,1993
cytogenetic analysis other fish lymphocyte 1 mmol/L ENMUDM 8,555,1986
cytogenetic analysis intraperitoneal
rat
19 mg/kg NULSAK 33,14,1990
DNA repair other microorganisms 10 mg/plate BIZNAT 95,463,1976
unscheduled DNA synthesis human fibroblast 100 mol/L MUREAV 42,161,1977
unscheduled DNA synthesis intraperitoneal
mouse
80 mg/kg APTOA6 55,104,1984
host-mediated assay mouse
Salmonella typhimurium
465 mg/kg/3 day- continuous BECTA6 25,277,1980
mutation in microorganisms Escherichia coli 1 mmol/L/4 hour (-enzymatic activation step) MUREAV 20,7,1973
mutation in microorganisms other microorganisms 100 mg/L (-enzymatic activation step) CYGEDX 15(3),64,1981
mutation in microorganisms Salmonella typhimurium 5 g/plate (+enzymatic activation step) IJEBA6 24,305,1986
mutation in microorganisms Salmonella typhimurium 500 g/plate (-enzymatic activation step) JTEHD6 16,403,1985
mutation in microorganisms Saccharomyes cerevisiae 10 gm/L (+/-enzymatic activation step) MUREAV 321,203,1994
micronucleus test human lymphocyte 10 mg/L MUREAV 388,27,1997
micronucleus test oral
mouse
103 mg/kg/24 hour BECTA6 25,277,1980
micronucleus test intraperitoneal
rat
47,500 g/kg NULSAK 33,14,1990
gene conversion and mitotic recombination Saccharomyes cerevisiae 66 mmol/L/27 hour IARCCD 10,161,1974
other mutation test systems oral
mouse
1,376 g/kg/10 day- continuous MUREAV 299,29,1993
sister chromatid exchange hamster lung 20 mg/L ENMUDM 4,621,1982
sister chromatid exchange human lymphocyte 2 mg/L MUREAV 102,89,1982
sister chromatid exchange human embryo 229 mg/L SNSHBT (20),574,1980
sister chromatid exchange other fish lymphocyte 300 mol/L ENMUDM 8,555,1986
sex chromosome loss and nondisjunction parenteral
Drosophila melanogaster
10 ppm MUREAV 172,237,1986
sex chromosome loss and nondisjunction oral
Drosophila melanogaster
75 ppb/96 hour MUREAV 206,351,1988
specific locus test oral
Drosophila melanogaster
75 ppb/96 hour MUREAV 206,351,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 40 mg/kg (1 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death BIRUAA 13,238,1975
oral
cat
lowest published toxic dose: 108 mg/kg (14-22 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system JEPTDQ 2(6),1283,1979
oral
mouse
lowest published toxic dose: 1,050 mg/kg (multigenerations) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
TXAPA9 26,29,1973
oral
mouse
lowest published toxic dose: 220 mg/kg (6-16 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) JPFCD2 20,373,1985
oral
mouse
lowest published toxic dose: 440 mg/kg (6-16 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system JPFCD2 20,373,1985
oral
mouse
lowest published toxic dose: 300 mg/kg (4 week male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) REPTED 23,232,2007
oral
mouse
lowest published toxic dose: 560 mg/kg (4 week male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)
REPTED 23,232,2007
oral
mouse
lowest published toxic dose: 560 mg/kg (4 week male) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
REPTED 23,232,2007
oral
rat
lowest published toxic dose: 120 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system BECTA6 22,522,1979
oral
rat
lowest published toxic dose: 113 mg/kg (6-20 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects to embryo or fetus
IJEBA6 34,329,1996
oral
rat
lowest published toxic dose: 150 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
BDERB* 77,40,2006
oral
rat
lowest published toxic dose: 150 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death BDERB* 77,40,2006


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intramuscular
rat
lowest published toxic dose: 176 mg/kg/6 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Tumors
ARGEAR 41,311,1973
oral
rat
lowest published toxic dose: 256 mg/kg/4 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Tumors
ARGEAR 41,311,1973


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
guinea pig
lethal dose (10 percent kill): 390 mg/kg N/R TXAPA9 8,259,1966
intraperitoneal
hamster
lethal dose (50 percent kill): 160 mg/kg N/R ARTODN 58,152,1986
intraperitoneal
mouse
lethal dose (50 percent kill): 45 mg/kg Eye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
BJIMAG 21,52,1964
intraperitoneal
mouse
lowest published toxic dose: 50 mg/kg Behavioral: Change in motor activity (specific assay) BECTA6 70,138,2003
intraperitoneal
mouse
lowest published toxic dose: 100 mg/kg Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases
TXAPA9 224,98,2007
intraperitoneal
rat
lethal dose (50 percent kill): 100 mg/kg Eye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
BJIMAG 21,52,1964
intraperitoneal
rat
lowest published toxic dose: 350 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Blood: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TXCYAC 211,149,2005
intravenous
rat
lethal dose (50 percent kill): 450 mg/kg Eye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
BJIMAG 21,52,1964
oral
wild bird
lethal dose (50 percent kill): 6,600 g/kg N/R TXAPA9 21,315,1972
oral
cat
lethal dose (50 percent kill): 100 mg/kg Behavioral: Excitement GISAAA 28(3),21,1963
oral
chicken
lethal dose (50 percent kill): 25 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase JAFCAU 11,91,1963
oral
duck
lethal dose (50 percent kill): 42 mg/kg N/R DOEAAH 35,25,1979
oral
dog
lethal dose (50 percent kill): 400 mg/kg N/R SPEADM 78-1,31,1978
oral
guinea pig
lethal dose (50 percent kill): 350 mg/kg N/R PCOC** -,395,1966
oral
hamster
lethal dose (50 percent kill): 200 mg/kg Eye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
BJIMAG 21,52,1964
oral
human
lethal dose (50 percent kill): 30 mg/kg N/R GUCHAZ 6,209,1973
oral
man
lowest published toxic dose: 286 mg/kg Peripheral Nerve and Sensation: Fasciculations

Behavioral: Coma

Lung, Thorax, or Respiration: Dyspnea
ICMED9 12,110,1986
oral
man
lowest published toxic dose: 300 mg/kg Behavioral: Coma

Cardiac: Pulse rate decreased with fall in BP

Vascular: BP lowering not characterized in autonomic section
JTCTDW 24,69,1986
oral
man
lowest published toxic dose: 357 mg/kg Brain and Coverings: Other degenerative changes

Cardiac: Cardiomyopathy including infarction

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
JTCTDW 32,61,1994
oral
man
lowest published toxic dose: 179 mg/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
HETOEA 22,107,2003
oral
mouse
lethal dose (50 percent kill): 60 mg/kg Eye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
BJIMAG 21,52,1964
oral
quail
lethal dose (50 percent kill): 25 mg/kg N/R JAFCAU 29,772,1981
oral
rat
lethal dose (50 percent kill): 60 mg/kg N/R YKYUA6 30,623,1979
oral
rat
lowest published toxic dose: 5 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TOSCF2 92,235,2006
oral
rat
lowest published toxic dose: 75 mg/kg Behavioral: Ataxia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOSCF2 92,235,2006
oral
rabbit
lethal dose (50 percent kill): 300 mg/kg N/R SPEADM 78-1,31,1978
subcutaneous
hamster
lethal dose (50 percent kill): 60 mg/kg Eye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
BJIMAG 21,52,1964
subcutaneous
mouse
lethal dose (50 percent kill): 60 mg/kg Eye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
BJIMAG 21,52,1964
subcutaneous
rat
lethal dose (50 percent kill): 350 mg/kg Eye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
BJIMAG 21,52,1964
skin
guinea pig
lethal dose (50 percent kill): 965 mg/kg N/R TXAPA9 3,210,1961
skin
mouse
lethal dose (50 percent kill): 1 gm/kg N/R GISAAA 33(6),6,1968
skin
rat
lethal dose (50 percent kill): 353 mg/kg N/R BJIMAG 26,59,1969
skin
rabbit
lethal dose (50 percent kill): 1 gm/kg Behavioral: Excitement GISAAA 28(3),21,1963
unreported route
mouse
lethal dose (50 percent kill): 158 mg/kg N/R RISHDJ 23,101,1983
unreported route
rat
lethal dose (50 percent kill): 215 mg/kg N/R YKYUA6 28,225,1977


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published toxic concentration: 4,500 g/m3/8 hour/13 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 33(6),6,1968
inhalation
rat
lowest published toxic concentration: 4,500 g/m3/13 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 33(6),6,1968
inhalation
rat
lowest published toxic concentration: 257 g/m3/24 hour/15 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 41(9),7,1976
intraperitoneal
mouse
lowest published toxic dose: 60 mg/kg/30 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
TOLED5 91,1,1997
intraperitoneal
mouse
lowest published toxic dose: 120 mg/kg/30 day- intermittent Endocrine: Evidence of thyroid hyperfunction

Biochemical: Metabolism (intermediary): Other
TOLED5 91,1,1997
oral
chicken
lowest published toxic dose: 56 mg/kg/4 week- intermittent Liver: Other changes

Endocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
BECTA6 57,335,1996
oral
dog
lowest published toxic dose: 3,937 mg/kg/90 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXAPA9 3,210,1961
oral
mouse
lowest published toxic dose: 560 mg/kg/4 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain REPTED 23,232,2007
oral
mouse
lowest published toxic dose: 300 mg/kg/4 week- intermittent Related to Chronic Data: Changes in testicular weight REPTED 23,232,2007
oral
rat
lowest published toxic dose: 630 mg/kg/28 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
IJEBA6 30,394,1992
oral
rat
lowest published toxic dose: 1,092 mg/kg/52 week- continuous Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
BJIMAG 21,52,1964
oral
rat
lowest published toxic dose: 300 mg/kg/6 week- intermittent Brain and Coverings: Changes in surface EEG

Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NETEEC 10,429,1988
oral
rat
lowest published toxic dose: 3,330 mg/kg/90 day- continuous Eye: Other eye effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXAPA9 3,210,1961
oral
rat
lowest published toxic dose: 3,852 mg/kg/26 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli
JDGRAX 21,225,1994
oral
rat
lowest published toxic dose: 500 mg/kg/5 day- intermittent Skin: After systemic exposure: Dermatitis, other TOXID9 54,334,2000
oral
rat
lowest published toxic dose: 10,752 mg/kg/80 week- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field ENVRAL 34,193,1984
oral
rat
lowest published toxic dose: 5,208 mg/kg/80 week- continuous Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Blood: Leukemia

Reproductive: Paternal effects: Testes, epididymis, sperm duct
ENVRAL 34,193,1984
oral
rat
lowest published toxic dose: 5,376 mg/kg/80 week- continuous Blood: Leukemia ENVRAL 34,193,1984
oral
rat
lowest published toxic dose: 1,260 mg/kg/60 day- intermittent Gastrointestinal: Changes in structure or function of exocrine pancreas

Endocrine: Hyperglycemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
TOLED5 133,161,2002
oral
rat
lowest published toxic dose: 180 mg/kg/30 day- intermittent Brain and Coverings: Other degenerative changes

Liver: Hepatitis (hepatocellular necrosis), zonal

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXCYAC 215,173,2005
oral
rat
lowest published toxic dose: 600 mg/kg/30 day- intermittent Gastrointestinal: Changes in structure or function of exocrine pancreas

Gastrointestinal: Changes in pancreatic weight

Endocrine: Hyperglycemia
TXCYAC 231,137,2007
oral
rat
lowest published toxic dose: 1,200 mg/kg/30 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXCYAC 231,137,2007
oral
rat
lowest published toxic dose: 75 mg/kg/5 day- intermittent Behavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Hypermotility, diarrhea
BDERB* 77,40,2006
oral
rat
lowest published toxic dose: 150 mg/kg/10 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase BDERB* 77,40,2006
oral
rat
lowest published toxic dose: 112 mg/kg/4 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain BDERB* 77,40,2006
oral
rat
lowest published toxic dose: 196 mg/kg/7 day- intermittent Behavioral: Food intake (animal) BDERB* 77,40,2006
skin
mouse
lowest published toxic dose: 3 pph/6 week- intermittent Skin and Appendages: Other: Breast

Tumorigenic: Tumor types after systemic administration not seen spontaneously
ENVRAL 34,193,1984
skin
mouse
lowest published toxic dose: 3 pph/6 week- intermittent Blood: Leukemia ENVRAL 34,193,1984


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
AQMOAC #73-19,1973
TOXICOLOGY REVIEW
RREVAH 46,1,1973
TOXICOLOGY REVIEW
MZUZA8 (8),90,1973
TOXICOLOGY REVIEW
DTTIAF 80,485,1973
TOXICOLOGY REVIEW
RREVAH 63,1,1976
TOXICOLOGY REVIEW
ENVRAL 34,193,1984
TOXICOLOGY REVIEW
NULSAK 28,243,1985
TOXICOLOGY REVIEW
TOLED5 128,45,2002
TOXICOLOGY REVIEW
MUREAV 562,77,2004
TOXICOLOGY REVIEW
MUREAV 567,109,2004
TOXICOLOGY REVIEW
MUREAV 567,347,2004
TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
ENTOX* -,47,2005
TOXICOLOGY REVIEW
EJPHAZ 553,10,2006
TOXICOLOGY REVIEW
ENTOX* -,306,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
FEREAC 73,6867,2008
TOXICOLOGY REVIEW
MUREAV 654,114,2008
TOXICOLOGY REVIEW
FEREAC 73,6867,2008
TOXICOLOGY REVIEW
MUREAV 654,114,2008
TOXICOLOGY REVIEW
JTPAE7 19,1,2006
TOXICOLOGY REVIEW
MUREAV 543,251,2003
TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,113,1998
Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84534;
Number of Industries 2;
Total Number of Facilities 30;
Number of Occupations 2;
Total Number of Employees Exposed 90
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84534;
Number of Industries 1;
Total Number of Facilities 54;
Number of Occupations 1;
Total Number of Employees Exposed 1,665;
Total Number of Female Employees Exposed 107


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an insecticide
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat NCITR* NCI-TR-4,1977


REFERENCES:

CODEN
REFERENCE

APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
AQMOAC Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25, 1969-75(?). Discontinued.
ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1949-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BDERB*
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BIRUAA Biologische Rundschau. (VEB Gustav Fischer Verlag, Postfach 176, Jena DDR-6900, Ger. Dem. Rep.) V.1- 1963-
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Used as an insecticide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

ALT CAS #: 11096-20-1
ALT CAS #: 56833-73-9
Click Here for Additional Information about RTECS

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