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Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphorodithioic acid, S-(((p-chlorophenyl)thio)methyl) O,O-diethyl ester

RTECS #

TD5250000

CAS #

786-19-6

Updated

August 2003

Molecular Weight

342.87

Molecular Formula

C11H16ClO2PS3

Synonyms

Acarithion
Akarithion
Carbofenothion (Dutch)
Carbophenothion
Dagadip
Dithiophosphate de O,O-diethyle et de (4-chloro-phenyl) thiomethyle (French)
Endyl
ENT 23,708
Garrathion
Karbofenothion (Czech)
Lethox
Nephocarp
O,O-Diaethyl-S-((4-chlor-phenyl-thio)-methyl)dithiophosphat (German)
O,O-Diethyl dithiophosphoric acid p-chlorophenylthiomethyl ester
O,O-Diethyl p-chlorophenylmercaptomethyl dithiophosphate
O,O-Diethyl S-(4-chlorophenylthiomethyl) dithiophosphate
O,O-Diethyl S-(p-chlorophenylthiomethyl) phosphorodithioate
O,O-Diethyl S-p-chlorophenylthiomethyl dithiophosphate
O,O-Diethyl-S-((4-chloor-fenyl-thio)-methyl)-dithiofosfaat (Dutch)
O,O-Diethyl-S-p-chlorfenylthiomethylester kyseliny dithiofosforecne (Czech)
O,O-Dietil-S-((4-cloro-fenil-tio)-metile)-ditiofosfato (Italian)
Oleoakarithion
OMS 244
R-1303
S-((p-Chlorophenylthio)methyl) O,O-diethyl phosphorodithioate
S-(4-Chlorophenylthiomethyl)diethyl phosphorothiolothionate
Stauffer R-1,303
Trithion
Trithion miticide

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
sister chromatid exchangelymphocyte/human20 µg/LMUREAV 102,89,1982

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 27 mg/kgPSEBAA 129,699,1968
intraperitoneal/rat lethal dose (50 percent kill): 6 mg/kgAPCRAW 4,117,1961
oral/chicken lethal dose (50 percent kill): 57200 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
TXAPA9 11,49,1967
oral/domestic animal lethal dose (50 percent kill): 14 mg/kgEESADV 2,151,1978
oral/mouse lethal dose (50 percent kill): 218 mg/kgARSIM* 20,6,1966
oral/pigeon lethal dose (50 percent kill): 34800 µg/kgPSSCBG 6,245,1975
oral/quail lethal dose (50 percent kill): 56800 µg/kgPSSCBG 6,245,1975
oral/rabbit lethal dose (50 percent kill): 1250 mg/kgSPEADM 78-1,40,1978
oral/rat lethal dose (50 percent kill): 6800 µg/kgFMCHA2 -,C315,1991
oral/wild bird lethal dose (50 percent kill): 5600 µg/kgTXAPA9 21,315,1972
skin/rabbit lethal dose (50 percent kill): 1270 mg/kgPCOC** -,200,1966
skin/rat lethal dose (50 percent kill): 27 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement
TXAPA9 2,88,1960
subcutaneous/chicken lethal dose (50 percent kill): 640 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Food intake (animal)

Gastrointestinal: Hypermotility, diarrhea
BCPCA6 12,1377,1963

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 630 mg/kg/7D- continuousBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
PCBPBS 18,49,1982
oral/rat lowest published toxic dose: 7 mg/kg/4W- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 3,500,1961

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWAQMOAC #73-19,1973
TOXICOLOGY REVIEWRREVAH 46,1,1973
TOXICOLOGY REVIEWRREVAH 63,1,1976

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,95,1998

Status in Federal Agencies

OrganizationReference
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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