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Phosphorodithioic acid, S - ( (6 - chloro - 2 - oxo - 3 (2H) - benzoxazolyl) methyl) O,O - diethyl ester

RTECS #: TD5175000

CAS #: 2310-17-0


UPDATE: May 2007 MW: 367.82 MF: C12H15ClNO4PS2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 3 - (6 - Chloro - 2 - oxobenzoxazolin - 3 - yl) methyl O,O - diethyl phosphorothiolothionate
  2. 3 - Diethyldithiophosphorylmethyl - 6 - chlorobenzoxazolone - 2
  3. Azofene
  4. Benzophosphate
  5. Benzphos
  6. Chipman 11974
  7. ENT 27,163
  8. Fosalon
  9. NIA - 9241
  10. NPH - 1091
  11. Niagara 9241
  12. O,O - Diaethyl - S - (6 - chlor - benzoxazolon - 2 - on - 3 - yl) - dithiophosphat (German)
  13. O,O - Diaethyl - S - (6 - chlor - 2 - oxo - ben (b) - 1,3 - oxalin - 3 - yl) - methyl - dithiophosphat (German)
  14. O,O - Diethyl - S - ( (6 - chloor - 2 - oxo - benzoxazolin - 3 - yl) - methyl) - dithiofosfaat (Dutch)
  15. O,O - Diethyl S - (6 - chlorobenzoxazolinyl - 3 - methyl) dithiophosphate
  16. O,O - Diethyl S - ( (6 - chloro - 2 - oxobenzoxazolin - 3 - yl) methyl) phosphorodithioate
  1. O,O - Diethyl - S - (6 - chloro - 2 - oxo - benzoxazolin - 3 - yl) methyl - phosphorothiolothionate
  2. O,O - Diethyl phosphorodithioate, S - ester with 6 - chloro - 3 - (mercaptomethyl) - 2 - benzoxazolinone
  3. O,O - Dietil - S - ( (6 - cloro - 2 - oxo - benzossazolin - 3 - il) - metil) - ditiofosfato (Italian)
  4. P - 974
  5. Phosalon
  6. Phosalone
  7. Phosphorodithioic acid - S - ester of 6 - chloro - 3 - mercaptomethylbenzoxazyol - 2 - one
  8. RP 11,974
  9. Rhodia RP 11974
  10. Rubitox
  11. S - ( (3 - Benzoxazolinyl - 6 - chloro - 2 - oxo) methyl) O,O - diethyl phosphorodithioate
  12. S - ( (6 - Chloro - 2 - oxo - 3 (2H) - benzoxazolyl) methyl) O,O - diethyl phosphorodithioate
  13. S - (6 - Chloro - 3 - (mercaptomethyl) - 2 - benzoxazolinone) O,O - diethyl phosphorodithioate
  14. Zolon
  15. Zolone
  16. Zolone PM


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 264 mg/kg (1-22 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic PRKHDK 2,169,1976


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
cat
lethal dose (50 percent kill): 112 mg/kg N/R GTPZAB 14(12),46,1970
oral
chicken
lethal dose (50 percent kill): 661 mg/kg N/R VETNAL 54(11),75,1978
oral
guinea pig
lethal dose (50 percent kill): 150 mg/kg N/R GUCHAZ 6,408,1973
oral
mammal (species unspecified)
lowest published lethal dose: 400 mg/kg Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
IJTHEZ 1,186,1991
oral
mouse
lethal dose (50 percent kill): 73 mg/kg N/R GTPZAB 19(9),55,1975
oral
rat
lethal dose (50 percent kill): 85 mg/kg N/R KSKZAN 16(2),59,1978
skin
rat
lethal dose (50 percent kill): 390 mg/kg N/R WRPCA2 9,119,1970
skin
rabbit
lethal dose (50 percent kill): 1 gm/kg N/R 85DPAN -,-,1971/1976
unreported route
rat
lethal dose (50 percent kill): 135 mg/kg N/R 30ZDA9 -,371,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 515 g/kg/24 hour/92 day- continuous Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 41(7),10,1976
oral
dog
lowest published toxic dose: 3,640 mg/kg/2 year- continuous Blood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXAPA9 36,561,1976
oral
rat
lowest published toxic dose: 803 mg/kg/17 week- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Other changes

Vascular: Structural changes in vessels
EKMMA8 18,177,1979
oral
rat
lowest published toxic dose: 262 mg/kg/3 week- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
ENVRAL 44,126,1987
oral
rat
lowest published toxic dose: 524 mg/kg/26 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
GISAAA 50(2),73,1985
oral
rat
lowest published toxic dose: 8,925 mg/kg/2 year- continuous Brain and Coverings: Other degenerative changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXAPA9 36,561,1976


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
RREVAH 63,1,1976
TOXICOLOGY REVIEW
MUTAEX 21,93,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,142,1998
Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

On EPA IRIS database


REFERENCES:

CODEN
REFERENCE

30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976
EKMMA8 Eksperimentalna Meditsina i Morfologiya. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.1- 1962-
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada)
IJTHEZ International Journal of Toxicology, Occupational and Environmental Health. (Wiley Eastern, 4835/24 Ansari Road, Daryaganj New Delhi 110002, India) V.1- 1991-
KSKZAN Khimiya v Sel'skom Khozyaistve. Chemistry in Agriculture. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1963-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
PRKHDK Problemi na Khigienata. Problems in Hygiene. (Durzhavno Izdatel'stvo Meditsina i Fizkultura, Pl. Slaveikov 11, Sofia, Bulgaria) V.1- 1975-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1924-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

Used as an insecticide and acaricide

RTECS Compound Description:
   Agricultural Chemical
   Reproductive Effector

ALT CAS #: 54182-71-7
Click Here for Additional Information about RTECS

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