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Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphorodithioic acid, S-((6-chloro-2-oxo-3(2H)-benzoxazolyl)methyl) O,O-diethyl ester

RTECS #

TD5175000

CAS #

2310-17-0; 54182-71-7

Updated

October 2010

Molecular Weight

367.82

Molecular Formula

C12H15ClNO4PS2

Synonyms

3-(6-Chloro-2-oxobenzoxazolin-3-yl)methyl O,O-diethyl phosphorothiolothionate
3-Diethyldithiophosphorylmethyl-6-chlorobenzoxazolone-2
Azofene
Benzophosphate
Benzphos
Chipman 11974
ENT 27,163
Fosalon
NIA-9241
Niagara 9241
NPH-1091
O,O-Diaethyl-S-(6-chlor-2-oxo-ben(b)-1,3-oxalin-3-yl)-methyl-dithiophosphat (German)
O,O-Diaethyl-S-(6-chlor-benzoxazolon-2-on-3-yl)-dithiophosphat (German)
O,O-Diethyl phosphorodithioate, S-ester with 6-chloro-3-(mercaptomethyl)-2-benzoxazolinone
O,O-Diethyl S-((6-chloro-2-oxobenzoxazolin-3-yl)methyl) phosphorodithioate
O,O-Diethyl S-(6-chlorobenzoxazolinyl-3-methyl) dithiophosphate
O,O-Diethyl-S-((6-chloor-2-oxo-benzoxazolin-3-yl)-methyl)-dithiofosfaat (Dutch)
O,O-Diethyl-S-(6-chloro-2-oxo-benzoxazolin-3-yl)methyl-phosphorothiolothionate
O,O-Dietil-S-((6-cloro-2-oxo-benzossazolin-3-il)-metil)-ditiofosfato (Italian)
P-974
Phosalon
Phosalone
Phosphorodithioic acid-S-ester of 6-chloro-3-mercaptomethylbenzoxazyol-2-one
Rhodia RP 11974
RP 11,974
Rubitox
S-((3-Benzoxazolinyl-6-chloro-2-oxo)methyl) O,O-diethyl phosphorodithioate
S-((6-Chloro-2-oxo-3(2H)-benzoxazolyl)methyl) O,O-diethyl phosphorodithioate
S-(6-Chloro-3-(mercaptomethyl)-2-benzoxazolinone) O,O-diethyl phosphorodithioate
Zolon
Zolone
Zolone PM

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 264 mg/kg (1-22D pregnant)Reproductive: Effects on newborn: Biochemical and metabolicPRKHDK 2,169,1976

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/cat lethal dose (50 percent kill): 112 mg/kgGTPZAB 14(12),46,1970
oral/chicken lethal dose (50 percent kill): 661 mg/kgVETNAL 54(11),75,1978
oral/guinea pig lethal dose (50 percent kill): 150 mg/kgGUCHAZ 6,408,1973
oral/mammal (species unspecified) lowest published lethal dose: 400 mg/kgBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
IJTHEZ 1,186,1991
oral/mouse lethal dose (50 percent kill): 73 mg/kgGTPZAB 19(9),55,1975
oral/rat lethal dose (50 percent kill): 85 mg/kgKSKZAN 16(2),59,1978
skin/rabbit lethal dose (50 percent kill): 1 gm/kg85DPAN -,-,1971/1976
skin/rat lethal dose (50 percent kill): 390 mg/kgWRPCA2 9,119,1970
unreported route/rat lethal dose (50 percent kill): 135 mg/kg30ZDA9 -,371,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 515 µg/kg/24H/92D- continuousKidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 41(7),10,1976
oral/Dog lowest published toxic dose: 3640 mg/kg/2Y- continuousBlood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXAPA9 36,561,1976
oral/rat lowest published toxic dose: 803 mg/kg/17W- intermittentLiver: Hepatitis (hepatocellular necrosis), zonal

Liver: Other changes

Vascular: Structural changes in vessels
EKMMA8 18,177,1979
oral/rat lowest published toxic dose: 262 mg/kg/3W- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
ENVRAL 44,126,1987
oral/rat lowest published toxic dose: 524 mg/kg/26W- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
GISAAA 50(2),73,1985
oral/rat lowest published toxic dose: 8925 mg/kg/2Y- continuousBrain and Coverings: Other degenerative changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXAPA9 36,561,1976

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWRREVAH 63,1,1976
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWFEREAC 73,80317,2008
TOXICOLOGY REVIEWFCTOD7 47,2906,2009
TOXICOLOGY REVIEWFEREAC 74,46689,2009

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,142,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.5 mg/m3, JUN2003

Status in Federal Agencies

OrganizationReference
On EPA IRIS database
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