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Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphorochloridothioic acid, O,O-diethyl ester

RTECS #

TD1780000

CAS #

2524-04-1

Updated

February 2006

Molecular Weight

188.62

Molecular Formula

C4H10ClO2PS

Synonyms

Diethylchlorothiophosphate
Diethylchlorthiofosfat (Czech)
Ethyl PCT
O,O-Diethylphosphorochloridothioate
Phosphonothioic acid, chloro-, O,O-diethyl ester

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 725 mg/m3/2H85GMAT -,51,1982
inhalation/rat lethal concentration (50 percent kill): 20 ppm/4H85JCAE -,1172,1986
oral/guinea pig lethal dose (50 percent kill): 810 mg/kgEye: Lacrimation

Gastrointestinal: Changes in structure or function of salivary glands

Blood: Hemorrhage
HYSAAV 33(10-12),334,1968
oral/mouse lethal dose (50 percent kill): 800 mg/kg85GMAT -,51,1982
oral/rabbit lethal dose (50 percent kill): 900 mg/kgEye: Lacrimation

Gastrointestinal: Changes in structure or function of salivary glands

Blood: Hemorrhage
HYSAAV 33(10-12),334,1968
oral/rat lethal dose (50 percent kill): 1340 mg/kgEye: Lacrimation

Gastrointestinal: Changes in structure or function of salivary glands

Blood: Hemorrhage
HYSAAV 33(10-12),334,1968
skin/rabbit lowest published lethal dose: 200 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Blood: Other changes
NTIS** OTS0536769
unreported route/mouse lethal dose (50 percent kill): 750 mg/kgGISAAA 56(5),6,1991

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 1 mg/m3/24H/17W- continuousBrain and Coverings: Recordings from specific areas of CNS

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 56(5),6,1991

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X4068; Number of Industries 2; Total Number of Facilities 30; Number of Occupations 4; Total Number of Employees Exposed 1088; Total Number of Female Employees Exposed 187

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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