CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Phosphoric acid, 2 - chloro - 1 - (2,4 - dichlorophenyl) vinyl diethyl ester

RTECS #: TB8750000

CAS #: 470-90-6


UPDATE: February 2009 MW: 359.58 MF: C12H14Cl3O4P


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 2 - Chloro - 1 - (2,4 - dichlorophenyl) vinyl diethyl phosphate
  2. Apachlor
  3. Benzyl alcohol, 2,4 - dichloro - alpha - (chloromethylene) - , diethyl phosphate
  4. Birlane
  5. Birlane 10G
  6. C8949
  7. CGA 26351
  8. CVP (pesticide)
  9. Chlorfehwinfos (Polish)
  10. Chlorfenvinfos
  11. Chlorfenvinphos
  12. Chlorphenvinfos
  13. Chlorphenvinphos
  14. Compound 4072
  15. Dermaton
  16. Diethyl 1 - (2,4 - dichlorophenyl) - 2 - chlorovinyl phosphate
  17. ENT 24969
  18. Enolofos
  19. GC 4072
  1. Haptasol
  2. O,O - Diaethyl - O - 1 - (4,5 - dichlorphenyl) - 2 - chlor - vinyl - phosphat (German)
  3. O,O - Diethyl O - (2 - chloro - 1 - (2',4' - dichlorophenyl) vinyl) phosphate
  4. O,O - Dwuetylo - O - 1 - (2,4 - dwuchlorofenylo) - 2 - chlorowinylofosforan (Polish)
  5. O - 2 - Chlor - 1 - (2,4 - dichlor - phenyl) - vinyl - O,O - diaethylphosphat (German)
  6. O - 2 - Chloor - 1 - (2,4 - dichloor - fenyl) - vinyl - O,O - diethylfosfaat (Dutch)
  7. O - 2 - Cloro - 1 - (2,4 - dicloro - fenil) - vinil - O,O - dietilfosfato (Italian)
  8. OMS 1328
  9. Phosphate de O,O - diethyle et de O - 2 - chloro - 1 - (2,4 - dichlorophenyl) vinyle (French)
  10. Phosphoric acid, 2 - chloro - 1 - (2,4 - dichlorophenyl) ethenyl diethyl ester (9CI)
  11. SD 7859
  12. Sapecron
  13. Steladone
  14. Supona
  15. Tarene
  16. Unitox
  17. Vinyphate
  18. Zaprawa enolofos
  19. beta - 2 - Chloro - 1 - (2',4' - dichlorophenyl) vinyl diethylphosphate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 500 g/plate (+enzymatic activation step) MUREAV 116,185,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): 50 mg/m3/4 hour N/R PEMNDP 9,142,1991
intraperitoneal
chicken
lethal dose (50 percent kill): 23,100 g/kg N/R VETRAX 77,1140,1965
intraperitoneal
mouse
lethal dose (50 percent kill): 87 mg/kg N/R JPPMAB 19,612,1967
intraperitoneal
rat
lethal dose (50 percent kill): 8,500 g/kg N/R VETRAX 77,1140,1965
intraperitoneal
rat
lowest published toxic dose: 0.5 mg/kg Behavioral: Change in motor activity (specific assay) ANBEX* 62,75,2002
intraperitoneal
rat
lowest published toxic dose: 1 mg/kg Endocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
NRTXDN 26,159,2005
intravenous
dog
lethal dose (50 percent kill): 51 mg/kg Eye: Lacrimation

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Hypermotility, diarrhea
TXAPA9 17,323,1970
intravenous
mouse
lethal dose (50 percent kill): 87 mg/kg N/R JPPMAB 19,612,1967
intravenous
rat
lethal dose (50 percent kill): 6,600 g/kg Eye: Lacrimation

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Hypermotility, diarrhea
TXAPA9 17,323,1970
oral
wild bird
lethal dose (50 percent kill): 13 mg/kg N/R JTCEEM 6(3),175,1986
oral
chicken
lethal dose (50 percent kill): 29,100 g/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
TXAPA9 11,49,1967
oral
cattle
lethal dose (50 percent kill): 20 mg/kg N/R VETRAX 77,1140,1965
oral
dog
lethal dose (50 percent kill): 1,200 mg/kg N/R 85GYAV -,18,1971
oral
domestic animal
lethal dose (50 percent kill): 71,250 g/kg N/R VETRAX 77,1140,1965
oral
guinea pig
lethal dose (50 percent kill): 125 mg/kg N/R BCPCA6 16,949,1967
oral
mammal (species unspecified)
lethal dose (50 percent kill): 10 mg/kg N/R HPBIA9 21,53,1975
oral
mouse
lethal dose (50 percent kill): 65 mg/kg N/R OYYAA2 1,78,1967
oral
pigeon
lethal dose (50 percent kill): 13,300 g/kg N/R ASTTA8 (680),157,1979
oral
quail
lethal dose (50 percent kill): 148 mg/kg Peripheral Nerve and Sensation: Fasciculations

Gastrointestinal: Hypermotility, diarrhea
PSSCBG 2,148,1971
oral
rat
lethal dose (50 percent kill): 10 mg/kg N/R FMCHA2 -,C69,1991
oral
rabbit
lethal dose (50 percent kill): 300 mg/kg Eye: Lacrimation

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Hypermotility, diarrhea
TXAPA9 17,323,1970
subcutaneous
mouse
lethal dose (50 percent kill): 339 mg/kg N/R JPPMAB 19,612,1967
subcutaneous
rat
lethal dose (50 percent kill): 7 mg/kg N/R APYPAY 32,507,1981
skin
human
lowest published toxic dose: 10 mg/kg Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
IMSUAI 38,25,1969
skin
mouse
lethal dose (50 percent kill): 336 mg/kg N/R OYYAA2 1,78,1967
skin
rat
lethal dose (50 percent kill): 26,400 g/kg N/R APYPAY 32,507,1981
skin
rabbit
lethal dose (50 percent kill): 400 mg/kg Eye: Lacrimation

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Hypermotility, diarrhea
TXAPA9 17,323,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 2 mg/kg/3 week- intermittent Brain and Coverings: Changes in surface EEG

Brain and Coverings: Recordings from specific areas of CNS
TOLED5 135,S49,2002
intraperitoneal
rat
lowest published toxic dose: 2.5 mg/kg/5 day- intermittent Behavioral: Change in motor activity (specific assay)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
ANBEX* 62,75,2002
oral
dog
lowest published toxic dose: 2,100 g/kg/12 week- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXAPA9 17,323,1970
oral
mouse
lowest published toxic dose: 697 mg/kg/7 day- continuous Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
PCBPBS 18,49,1982
oral
rat
lowest published toxic dose: 420 mg/kg/12 week- continuous Endocrine: Changes in spleen weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXAPA9 17,323,1970
oral
rat
lowest published toxic dose: 49 mg/kg/35 week- intermittent Cardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
BCTKAG 10,243,1977
oral
rat
lowest published toxic dose: 182 mg/kg/26 week- intermittent Blood: Changes in leukocyte (WBC) count BCTKAG 9,267,1976
oral
rat
lowest published toxic dose: 4.2 mg/kg/14 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
FCTOD7 46,82,2008
subcutaneous
rat
lowest published toxic dose: 50,400 mg/kg/28 day- intermittent Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
APYPAY 31,575,1980
subcutaneous
rat
lowest published toxic dose: 14 mg/kg/17 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
APYPAY 32,507,1981


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
RREVAH 46,1,1973
TOXICOLOGY REVIEW
CNDQA8 10(3),43,1975
TOXICOLOGY REVIEW
RREVAH 63,1,1976
TOXICOLOGY REVIEW
JTPAE7 19,1,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,167,1998
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.01 mg/m3, MAC(short term exposure limit) 0.1 mg/m3, JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/98/101116/AS)


REFERENCES:

CODEN
REFERENCE

85GYAV "Pflanzenschutz-und Schaedlingsbekaempfungsmittel: Abriss einer Toxikologie und Therapie von Vergiftungen," 2nd ed., Klimmer, O.R., Hattingen, Fed. Rep. Ger., Hundt-Verlag, 1971
ANBEX* Acta neurobiologiae experimentalis (Warszawa : Nencki Institute of Experimental Biology) V. 30- 1970
APYPAY Acta Physiologica Polonica. (Karger-Libri, POB CH-4009, Warszawa, Switzerland) V.1-41, 1950-90.
ASTTA8 ASTM Special Technical Publication. (American Soc. for Testing Materials, 1916 Race St., Philadelphia, PA 19103) No.1- 1911-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971-
CNDQA8 Cahiers de Nutrition et de Dietetique. (Editions Meteore, 42, rue du Louvre, 75001 Paris, France) V.1- 1966-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
HPBIA9 Herba Polonica. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.11- 1965-
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5.
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
JTCEEM Journal de Toxicologie Clinique et Experimentale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.5- 1985-
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971-
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
PSSCBG Pesticide Science. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1970-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VETRAX Veterinary Record. (7 Mansfield St., London W1M 0AT, UK) V.1- 1888-

Used as a soil insecticide for root maggots, rootworms and cutworms

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Human Data

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us