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Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphoric acid, 2-chloro-1-(2,4-dichlorophenyl)vinyl diethyl ester

RTECS #

TB8750000

CAS #

470-90-6

Updated

December 2010

Molecular Weight

359.58

Molecular Formula

C12H14Cl3O4P

Synonyms

2-Chloro-1-(2,4-dichlorophenyl)vinyl diethyl phosphate
Apachlor
Benzyl alcohol, 2,4-dichloro-alpha-(chloromethylene)-, diethyl phosphate
beta-2-Chloro-1-(2',4'-dichlorophenyl) vinyl diethylphosphate
Birlane
Birlane 10G
C8949
CGA 26351
Chlorfehwinfos (Polish)
Chlorfenvinfos
Chlorfenvinphos
Chlorphenvinfos
Chlorphenvinphos
Compound 4072
CVP (pesticide)
Dermaton
Diethyl 1-(2,4-dichlorophenyl)-2-chlorovinyl phosphate
Enolofos
ENT 24969
GC 4072
Haptasol
O,O-Diaethyl-O-1-(4,5-dichlorphenyl)-2-chlor-vinyl-phosphat (German)
O,O-Diethyl O-(2-chloro-1-(2',4'-dichlorophenyl)vinyl) phosphate
O,O-Dwuetylo-O-1-(2,4-dwuchlorofenylo)-2-chlorowinylofosforan (Polish)
O-2-Chloor-1-(2,4-dichloor-fenyl)-vinyl-O,O-diethylfosfaat (Dutch)
O-2-Chlor-1-(2,4-dichlor-phenyl)-vinyl-O,O-diaethylphosphat (German)
O-2-Cloro-1-(2,4-dicloro-fenil)-vinil-O,O-dietilfosfato (Italian)
OMS 1328
Phosphate de O,O-diethyle et de O-2-chloro-1-(2,4-dichlorophenyl) vinyle (French)
Phosphoric acid, 2-chloro-1-(2,4-dichlorophenyl)ethenyl diethyl ester (9CI)
Sapecron
SD 7859
Steladone
Supona
Tarene
Unitox
Vinyphate
Zaprawa enolofos

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium500 µg/plate (+enzymatic activation step)MUREAV 116,185,1983

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 50 mg/m3/4HPEMNDP 9,142,1991
intraperitoneal/chicken lethal dose (50 percent kill): 23100 µg/kgVETRAX 77,1140,1965
intraperitoneal/mouse lethal dose (50 percent kill): 87 mg/kgJPPMAB 19,612,1967
intraperitoneal/rat lethal dose (50 percent kill): 8500 µg/kgVETRAX 77,1140,1965
intraperitoneal/rat lowest published toxic dose: 0.5 mg/kgBehavioral: Change in motor activity (specific assay)ANBEX* 62,75,2002
intraperitoneal/rat lowest published toxic dose: 1 mg/kgEndocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
NRTXDN 26,159,2005
intravenous/Dog lethal dose (50 percent kill): 51 mg/kgEye: Lacrimation

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Hypermotility, diarrhea
TXAPA9 17,323,1970
intravenous/mouse lethal dose (50 percent kill): 87 mg/kgJPPMAB 19,612,1967
intravenous/rat lethal dose (50 percent kill): 6600 µg/kgEye: Lacrimation

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Hypermotility, diarrhea
TXAPA9 17,323,1970
oral/cattle lethal dose (50 percent kill): 20 mg/kgVETRAX 77,1140,1965
oral/chicken lethal dose (50 percent kill): 29100 µg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
TXAPA9 11,49,1967
oral/Dog lethal dose (50 percent kill): 1200 mg/kg85GYAV -,18,1971
oral/domestic animal lethal dose (50 percent kill): 71250 µg/kgVETRAX 77,1140,1965
oral/guinea pig lethal dose (50 percent kill): 125 mg/kgBCPCA6 16,949,1967
oral/mammal (species unspecified) lethal dose (50 percent kill): 10 mg/kgHPBIA9 21,53,1975
oral/mouse lethal dose (50 percent kill): 65 mg/kgOYYAA2 1,78,1967
oral/pigeon lethal dose (50 percent kill): 13300 µg/kgASTTA8 (680),157,1979
oral/quail lethal dose (50 percent kill): 148 mg/kgPeripheral Nerve and Sensation: Fasciculations

Gastrointestinal: Hypermotility, diarrhea
PSSCBG 2,148,1971
oral/rabbit lethal dose (50 percent kill): 300 mg/kgEye: Lacrimation

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Hypermotility, diarrhea
TXAPA9 17,323,1970
oral/rat lethal dose (50 percent kill): 10 mg/kgFMCHA2 -,C69,1991
oral/rat lowest published toxic dose: 6 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseBCLPT* 105,37,2009
oral/wild bird lethal dose (50 percent kill): 13 mg/kgJTCEEM 6(3),175,1986
skin/human lowest published toxic dose: 10 mg/kgBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
IMSUAI 38,25,1969
skin/mouse lethal dose (50 percent kill): 336 mg/kgOYYAA2 1,78,1967
skin/rabbit lethal dose (50 percent kill): 400 mg/kgEye: Lacrimation

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Hypermotility, diarrhea
TXAPA9 17,323,1970
skin/rat lethal dose (50 percent kill): 26400 µg/kgAPYPAY 32,507,1981
subcutaneous/mouse lethal dose (50 percent kill): 339 mg/kgJPPMAB 19,612,1967
subcutaneous/rat lethal dose (50 percent kill): 7 mg/kgAPYPAY 32,507,1981

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 2 mg/kg/3W- intermittentBrain and Coverings: Changes in surface EEG

Brain and Coverings: Recordings from specific areas of CNS
TOLED5 135,S49,2002
intraperitoneal/rat lowest published toxic dose: 2.5 mg/kg/5D- intermittentBehavioral: Change in motor activity (specific assay)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
ANBEX* 62,75,2002
oral/Dog lowest published toxic dose: 2100 µg/kg/12W- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTXAPA9 17,323,1970
oral/mouse lowest published toxic dose: 697 mg/kg/7D- continuousBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
PCBPBS 18,49,1982
oral/rat lowest published toxic dose: 4.2 mg/kg/14D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
FCTOD7 46,82,2008
oral/rat lowest published toxic dose: 420 mg/kg/12W- continuousEndocrine: Changes in spleen weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXAPA9 17,323,1970
oral/rat lowest published toxic dose: 49 mg/kg/35W- intermittentCardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
BCTKAG 10,243,1977
oral/rat lowest published toxic dose: 182 mg/kg/26W- intermittentBlood: Changes in leukocyte (WBC) countBCTKAG 9,267,1976
subcutaneous/rat lowest published toxic dose: 50400 mg/kg/28D- intermittentLiver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
APYPAY 31,575,1980
subcutaneous/rat lowest published toxic dose: 14 mg/kg/17W- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
APYPAY 32,507,1981

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWRREVAH 46,1,1973
TOXICOLOGY REVIEWCNDQA8 10(3),43,1975
TOXICOLOGY REVIEWRREVAH 63,1,1976
TOXICOLOGY REVIEWJTPAE7 19,1,2006
TOXICOLOGY REVIEWHETOEA 26,321,2007
TOXICOLOGY REVIEWNBREV* 9,479,1985

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,167,1998
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.01 mg/m3, MAC(short term exposure limit) 0.1 mg/m3, JAN1999

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/98/101116/AS)
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