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Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphoramidothioic acid, O,S-dimethyl ester

RTECS #

TB4970000

CAS #

10265-92-6

Updated

July 2013

Molecular Weight

141.14

Molecular Formula

C2H8NO2PS

Synonyms

Acephate-met
BAY 71628
Bayer 71628
Chevron 9006
Chevron ortho 9006
ENT 27,396
Hamidop
Metamidofos estrella
Methamidophos
Monitor
NSC 190987
O,S-Dimethyl ester amide of amidothioate
O,S-Dimethyl phosphoramidothioate
Ortho 9006
Pillaron
SRA 5172
Tahmabon
Tamaron
Thiophosphorsaeure-O,S-dimethylesteramid (German)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisother cell types/mouse2 mg/LZNCBDA 42,21,1987
micronucleus testintraperitoneal/mouse6 mg/kgZNCBDA 42,21,1987
micronucleus testoral/mouse84 mg/kg/1W-continuousZNCBDA 42,21,1987
micronucleus testskin/mouse96 mg/kg/2W- intermittentZNCBDA 42,21,1987
sister chromatid exchangeintraperitoneal/mouse6 mg/kgZNCBDA 42,21,1987
sister chromatid exchangeother cell types/mouse250 µg/LZNCBDA 42,21,1987

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse 3750 µg/kg (1D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)TXAPA9 165,148,2000
oral/rat 6 mg/kg (1-6D pregnant)Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Skin and skin appendages

Reproductive: Specific developmental abnormalities: Urogenital system
VHTODE 42,361,2000
oral/rat 21.5 mg/kg (0D preg-21D after birth)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)
TOXID9 66,133,2002
oral/rat 64.5 mg/kg (0D preg-21D after birth)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Other developmental abnormalities
TOXID9 66,133,2002
oral/rat 10 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear
VEMJA8 34,357,1986
oral/mouse 4 mg/kg (5D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
ZYYZEW 2,142,1988

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 162 mg/m3/4H85JFAN A265,1984
intraperitoneal/mouse lethal dose (50 percent kill): 5300 µg/kgPCBPBS 7,83,1977
intraperitoneal/mouse lowest published toxic dose: 3 mg/kgBrain and Coverings: Other degenerative changesTOLED5 135,89,2002
intraperitoneal/rat lethal dose (50 percent kill): 10 mg/kgTOXID9 1,52,2001
intraperitoneal/rat lowest published toxic dose: 5 mg/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Endocrine: Other changes
TOXID9 1,52,2001
intraperitoneal/rat lethal dose (50 percent kill): 15 mg/kgEye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Skin and Appendages: Other: Hair
PCBPBS 13,267,1980
intravenous/rat lethal dose (50 percent kill): 10 mg/kgEye: Lacrimation

Behavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands
PCBPBS 18,28,1982
oral/chicken lethal dose (50 percent kill): 25 mg/kg28ZEAL 5,149,1976
oral/domestic bird lethal dose (50 percent kill): 8 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
AECTCV 10,185,1981
oral/guinea pig lethal dose (50 percent kill): 30 mg/kg28ZEAL 5,149,1976
oral/man lowest published toxic dose: 1429 µL/kgBehavioral: General anesthetic

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory stimulation
ARTODN 73,296,1999
oral/man lowest published toxic dose: 257 mg/kgPeripheral Nerve and Sensation: Fasciculations

Eye: Miosis (pupilliary constriction)

Skin and Appendages: Other: Sweating
NEJMAG 306,125,1982
oral/man lowest published toxic dose: 600 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Autonomic Nervous System: Parasympatholytic

Behavioral: Coma
TOXID9 14,390,1994
oral/mouse lethal dose (50 percent kill): 14 mg/kgPCBPBS 7,83,1977
oral/quail lethal dose (50 percent kill): 57500 µg/kgPEMNDP 9,563,1991
oral/rabbit lethal dose (50 percent kill): 10 mg/kg28ZEAL 5,149,1976
oral/rat lethal dose (50 percent kill): 7500 µg/kgARSIM* 20,7,1966
oral/rat lowest published toxic dose: 5 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold
EESADV 64,251,2006
oral/woman lowest published toxic dose: 360 mg/kgPeripheral Nerve and Sensation: Fasciculations

Eye: Miosis (pupilliary constriction)

Skin and Appendages: Other: Sweating
NEJMAG 306,125,1982
skin/rabbit lethal dose (50 percent kill): 100 mg/kgENTOX* -,51,2005
skin/rat lethal dose (50 percent kill): 50 mg/kg28ZEAL 5,149,1976
subcutaneous/guinea pig lowest published lethal dose: 10 mg/kgJEENAI 62,934,1969
unreported route/mouse lethal dose (50 percent kill): 27 mg/kgJAFCAU 18,189,1970

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 3.93 mg/kg/30D- continuousBehavioral: Change in motor activity (specific assay)

Behavioral: Change in psychophysiological tests

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NRTXDN 30,471,2009
oral/mouse lowest published toxic dose: 11.34 mg/kg/30D- continuousBrain and Coverings: Other degenerative changesNETOX* 32,718,2011
oral/rat lowest published toxic dose: 71890 µg/kg/13W- continuousBrain and Coverings: Other degenerative changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
FAATDF 35,101,1997
oral/rat lowest published toxic dose: 90 µL/kg/9D- continuousBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
EVMJB9 49,833,1989
oral/rat lowest published toxic dose: 2.15 mg/kg/43D- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 66,133,2002
oral/rat lowest published toxic dose: 50.4 mg/kg/16W- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseNETEEC 27,279,2005
oral/rat lowest published toxic dose: 45 mg/kg/9W- intermittentBrain and Coverings: Other degenerative changesEESADV 64,251,2006

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 557,109,2004
TOXICOLOGY REVIEWTOLED5 128,45,2002
TOXICOLOGY REVIEWTOLED5 127,29,2002
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWCCATAR 366,1,2006
TOXICOLOGY REVIEWENTOX* -,51,2005
TOXICOLOGY REVIEWENTOX* -,306,2005
TOXICOLOGY REVIEWFEREAC 72,28912,2007
TOXICOLOGY REVIEWJCMEA* 70,467,2007
TOXICOLOGY REVIEWHETOEA 26,321,2007
TOXICOLOGY REVIEWFCTOD7 47,2906,2009
TOXICOLOGY REVIEWFEREAC 74,57078,2009
TOXICOLOGY REVIEWMUTAEX 26,19,2011

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,130,1998
Occupational Exposure Limit-HUNGARYSkin, SEP2000

Status in Federal Agencies

OrganizationReference
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600
On EPA IRIS database
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