Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphoramidothioic acid, N-acetyl-, O,S-dimethyl ester

RTECS #

TB4760000

CAS #

30560-19-1

Updated

December 2013

Molecular Weight

183.18

Molecular Formula

C4H10NO3PS

Synonyms

75 SP
Acephat (German)
Acephate
Acetamidophos
Acetylphosphoramidothioic acid O,S-dimethyl ester
Aimthane
Asataf
Chevron RE 12,420
ENT 27822
Kitron
N-(Methoxy(methylthio)phosphinoyl)acetamide
O,S - dimethyl acetyl phosphoramidothioate
O,S-Dimethylacetylphosphoroamidothioate
Orthene
Orthene-755
Ortho 124120
Ortho 12420
Ortran
Ortril
Pillarthene
RE 12420

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisintraperitoneal/mouse150 mg/kgMUREAV 223,287,1989
DNA Damageoral/mouse12.25 mg/kgMUREAV 516,139,2002
Dominant Lethal Testintraperitoneal/mouse250 mg/kg/5D-continuousMUREAV 223,287,1989
gene conversion and mitotic recombination/Saccharomyes cerevisiae50000 ppmNTIS** PB80-133226
micronucleus testintraperitoneal/mouse500 mg/kg/24HMUREAV 223,287,1989
mutation in mammalian somatic cellslymphocyte/mouse1 gm/LNTIS** PB84-138973
mutation in microorganisms/Salmonella typhimurium3 mg/plate (+enzymatic activation step)NTIS** PB80-133226
mutation in microorganisms/Salmonella typhimurium50 mg/plate (-enzymatic activation step)MUREAV 116,185,1983
mutation in microorganisms/Escherichia coli5 mg/plate (-enzymatic activation step)MUREAV 28,405,1975
mutation in microorganisms/Saccharomyes cerevisiae3 pph (+enzymatic activation step)NTIS** PB84-138973
sister chromatid exchangeovary/hamster2 gm/LNTIS** PB84-138973
sperm morphologyintraperitoneal/mouse150 mg/kg/5D-continuousMUREAV 223,287,1989
Unscheduled DNA Synthesisfibroblast/human1 gm/LNTIS** PB80-133226

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse 150 mg/kg (5D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)MUREAV 223,287,1989
intraperitoneal/mouse 200 mg/kg (5D male)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)MUREAV 223,287,1989
oral/mouse 560 mg/kg (20D male)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
REPTED 14,457,2000
oral/mouse 140 mg/kg (6-15D pregnant)Reproductive: Other effects on femaleREPTED 14,241,2000
oral/mouse 280 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
REPTED 14,241,2000

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse Lowest published lethal concentration: 2200 mg/m3/5HTXAPA9 45,232,1978
intraperitoneal/mouse lowest published toxic dose: 30 mg/kgBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases
TXAPA9 224,98,2007
intraperitoneal/rat lowest published toxic dose: 100 mg/kgEndocrine: Other changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
JJATDK 22,279,2002
intraperitoneal/rat lowest published toxic dose: 500 mg/kgBehavioral: Tremor

Blood: Changes in leukocyte (WBC) count

Immunological Including Allergic: Decrease in cellular immune response
JJATDK 22,279,2002
intraperitoneal/rat lowest published toxic dose: 100 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseJAPTO* 22,279,2002
intraperitoneal/rat lowest published toxic dose: 500 mg/kgBlood: Changes in leukocyte (WBC) countJAPTO* 22,279,2002
intraperitoneal/rat lethal dose (50 percent kill): 1000 mg/kgTOXID9 1,52,2001
intraperitoneal/rat lowest published toxic dose: 500 mg/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Endocrine: Other changes
TOXID9 1,52,2001
intrauterine/rat lowest published toxic dose: 140 mg/kgEndocrine: Hyperglycemia

Endocrine: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXCYAC 257,40,2009
oral/chicken lethal dose (50 percent kill): 800 mg/kgNRTXDN 11,483,1990
oral/Dog lowest published lethal dose: 681 mg/kgGUCHAZ 6,1,1973
oral/domestic bird lethal dose (50 percent kill): 106 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
AECTCV 10,185,1981
oral/duck lethal dose (50 percent kill): 350 mg/kg28ZEAL 5,4,1976
oral/mammal (species unspecified) lethal dose (50 percent kill): 321 mg/kgAECTCV 13,483,1984
oral/mouse lethal dose (50 percent kill): 233 mg/kgCHYCDW 14,226,1980
oral/rat lethal dose (50 percent kill): 700 mg/kgUSXXAM #3716600
oral/rat lowest published toxic dose: 3 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTOSCF2 92,235,2006
oral/rat lowest published toxic dose: 120 mg/kgBehavioral: Alteration of classical conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOSCF2 92,235,2006
oral/rat lethal dose (50 percent kill): 850 mg/kgBehavioral: Muscle weakness

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting
ENTOX* -,13,2005
oral/wild bird lethal dose (50 percent kill): 140 mg/kgPEMNDP 9,4,1991
skin/rabbit lethal dose (50 percent kill): 2 gm/kg85DPAN -,-,1971/1976
skin/rat lethal dose (50 percent kill): >2500 mg/kgFAATDF 7,299,1986
unreported route/chicken lethal dose (50 percent kill): 568 mg/kgDEVEAA 28,231,1974

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 375 mg/kg/3D- intermittentLung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
FCTOD7 43,173,2005
intraperitoneal/mouse lowest published toxic dose: 750 mg/kg/3D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldFCTOD7 43,173,2005
oral/mouse lowest published toxic dose: 15 mg/kg/5D- continuousBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOLED5 24,65,1985
oral/mouse lowest published toxic dose: 13500 mg/kg/90D- intermittentLiver: Other changesHOEKAN 22,48,1922
oral/mouse lowest published toxic dose: 280 mg/kg/10D- intermittentAutonomic Nervous System: Parasympatholytic

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
REPTED 14,241,2000
oral/mouse lowest published toxic dose: 140 mg/kg/10D- intermittentBrain and Coverings: Changes in brain weightREPTED 14,241,2000
oral/mouse lowest published toxic dose: 560 mg/kg/20D- intermittentBehavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands

Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)
REPTED 14,457,2000
oral/mouse lowest published toxic dose: 280 mg/kg/20D- intermittentReproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)

Related to Chronic Data: Changes in testicular weight
REPTED 14,457,2000
oral/mouse lowest published toxic dose: 140 mg/kg/20D- intermittentBehavioral: Muscle weaknessREPTED 14,457,2000
oral/mouse lowest published toxic dose: 110250 mg/kg/105W- continuousLiver: TumorsHBPTO* 1,814,2001
oral/rat lowest published toxic dose: 712 mg/kg/4D- intermittentBrain and Coverings: Other degenerative changesTOXID9 72,74,2003
oral/rat lowest published toxic dose: 140 mg/kg/20W- intermittentBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationTIHEEC 19,93,2003
oral/rat lowest published toxic dose: 420 mg/kg/14D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
FCTOD7 48,2766,2010
oral/rat lowest published toxic dose: 14580 mg/kg/90D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
CHYCDW 14,226,1980
oral/rat lowest published toxic dose: 1050 mg/kg/15W- intermittentBrain and Coverings: Other degenerative changes

Autonomic Nervous System: Sympathomimetic

Biochemical: Metabolism (intermediary): Amino acids (including renal excretion)
ENVRAL 43,342,1987
oral/rat lowest published toxic dose: 33600 mg/kg/8W- intermittentLiver: Other changes

Biochemical: Metabolism (intermediary): Other proteins
IJEBA6 21,684,1983

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWTOLED5 127,29,2002
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWENTOX* -,13,2005
TOXICOLOGY REVIEWFEREAC 72,44439,2007
TOXICOLOGY REVIEWFEREAC 73,5104,2008
TOXICOLOGY REVIEWJTPAE7 19,1,2006
TOXICOLOGY REVIEWFCTOD7 47,2906,2009
TOXICOLOGY REVIEWMUREAV 721,27,2011
TOXICOLOGY REVIEWNRTXDN 33,575,2012

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,82,1998

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code T0473; Number of Industries 2; Total Number of Facilities 196; Number of Occupations 1; Total Number of Employees Exposed 770; Total Number of Female Employees Exposed 378

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
TOP