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Phosphonic acid, (2,2,2 - trichloro - 1 - hydroxyethyl) - , dimethyl ester

RTECS #: TA0700000

CAS #: 52-68-6


UPDATE: May 2009 MW: 257.44 MF: C4H8Cl3O4P


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. ( (2,2,2 - Trichloro - 1 - hydroxyethyl) dimethylphosphonate)
  2. (2,2,2 - Trichloro - 1 - hydroxyethyl) phosphonic acid dimethyl ester
  3. 1 - Hydroxy - 2,2,2 - trichloro - ethyle phosphonate de dimethyle (French)
  4. 1 - Hydroxy - 2,2,2 - trichloroethylphosphonic acid dimethyl ester
  5. 2,2,2 - Trichloroethyl dimethyl phosphate
  6. Aerol 1
  7. Aerol 1 (pesticide)
  8. Agroforotox
  9. Anthon
  10. BAY 15922
  11. Bayer 15922
  12. Bayer L 13/59
  13. Bilarcil
  14. Bovinox
  15. Briton
  16. Britten
  17. Cekufon
  18. Chlorak
  19. Chlorfos
  20. Chlorofos
  21. Chloroftalm
  22. Chlorophos
  23. Chlorophose
  24. Chlorophthalm
  25. Chloroxyphos
  26. Ciclosom
  27. Combot
  28. Combot equine
  29. DEP (pesticide)
  30. DETF
  31. Danex
  32. Depthon
  33. Dimethoxy - 2,2,2 - trichloro - 1 - hydroxy - ethyl - phosphine oxide
  34. Dimethyl 1 - hydroxy - 2,2,2 - trichloroethyl phosphonate
  35. Dimethyl 2,2,2 - trichloro - 1 - hydroxyethylphosphonate
  36. Dimethyltrichlorohydroxyethyl phosphonate
  37. Dimetox
  38. Dipterex
  39. Dipterex 50
  40. Diptevur
  41. Ditrifon
  42. Dylox
  43. Dylox - metasystox - R
  44. Dyrex
  45. Dyvon
  46. ENT 19,763
  47. Equino - aid
  48. Flibol E
  49. Fliegenteller
  50. Forotox
  51. Foschlor
  1. Foschlor 25
  2. Foschlor R
  3. Foschlor R - 50
  4. Foschlorem (Polish)
  5. Hypodermacid
  6. Leivasom
  7. Loisol
  8. Masoten
  9. Mazoten
  10. Methyl chlorophos
  11. Metrifonate
  12. Metriphonate
  13. NCI - C54831
  14. Neguvon
  15. O,O Dimetil 2,2,2 - trichloro 1 hidroxietil fosfonato (Portugese)
  16. O,O - Dimethyl (1 - hydroxy - 2,2,2 - trichloroethyl) phosphonate
  17. O,O - Dimethyl (2,2,2 - trichloro - 1 - hydroxyethyl) phosponate
  18. O,O - Dimethyl - (1 - hydroxy - 2,2,2 - trichloraethyl) phosphonsaeure ester (German)
  19. O,O - Dimethyl - (1 - hydroxy - 2,2,2 - trichlorathyl) - phosphat (German)
  20. O,O - Dimethyl - (1 - hydroxy - 2,2,2 - trichloro) ethyl phosphate
  21. O,O - Dimethyl - (2,2,2 - trichloor - 1 - hydroxy - ethyl) - fosfonaat (Dutch)
  22. O,O - Dimethyl - (2,2,2 - trichlor - 1 - hydroxy - aethyl) phosphonat (German)
  23. O,O - Dimethyl - 1 - oxy - 2,2,2 - trichloroethyl phosphonate
  24. O,O - Dimetil - (2,2,2 - tricloro - 1 - idrossi - etil) - fosfonato (Italian)
  25. Phoschlor
  26. Phoschlor R50
  27. Phosphonic acid, (1 - hydroxy - 2,2,2 - trichloroethyl) - , dimethyl ester
  28. Polfoschlor
  29. Proxol
  30. Ricifon
  31. Ritsifon
  32. Satox 20WSC
  33. Soldep
  34. Sotipox
  35. Trichloorfon (Dutch)
  36. Trichlorfon
  37. Trichlorfon (German)
  38. Trichlorofon
  39. Trichlorophon
  40. Trichlorphon
  41. Trichlorphon FN
  42. Trinex
  43. Tugon
  44. Tugon fly bait
  45. Tugon stable spray
  46. Vermicide bayer 2349
  47. Volfartol
  48. Votexit
  49. WEC 50
  50. Wotexit


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
120 mg/6 day- intermittent mild BUMMAB 9,7,1955


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
body fluid assay mouse
Salmonella typhimurium
200 mg/kg CNREA8 38,4478,1978
cytogenetic analysis hamster lung 81 mg/L GMCRDC 27,95,1981
cytogenetic analysis human leukocyte 40 mg/L HOEKAN 29,33,1979
cytogenetic analysis oral
mouse
100 mg/kg SOGEBZ 11,1534,1975
cytogenetic analysis oral
mouse
8,500 g/kg GISAAA 45(1),80,1980
cytogenetic analysis intraperitoneal
mouse
51,500 g/kg EESADV 13,216,1987
cytogenetic analysis mouse ovary 50 g/plate/16 hour MUREAV 564,165,2004
cytogenetic analysis unreported route
mouse
8,800 mg/kg/22 day- intermittent MUTAEX 20,469,2005
cytogenetic analysis mouse ovary 50 mg/L/16 hour MUREAV 652,114,2008
cytogenetic analysis multiple
other fish
1 L/L JFIBA9 26,13,1985
dominant lethal test intraperitoneal
mouse
405 mg/kg ARTODN 33,163,1975
DNA damage intraperitoneal
mouse
160 mg/kg PCBPBS 6,101,1976
DNA repair other microorganisms 10 mg/plate BIZNAT 95,463,1976
unscheduled DNA synthesis human other cell types 4 mole/L PSSCBG 15,439,1984
unscheduled DNA synthesis human fibroblast 100 mg/L NTIS** PB80-133226
host-mediated assay mouse
Salmonella typhimurium
50 mg/kg JPETAB 200,1,1977
mutation in microorganisms Escherichia coli 8,650 g/plate (-enzymatic activation step) MUREAV 28,405,1975
mutation in microorganisms Escherichia coli 1 mg/plate (+enzymatic activation step) NTIS** PB80-133226
mutation in microorganisms other microorganisms 4 mg/plate (-enzymatic activation step) CBINA8 22,297,1978
mutation in microorganisms Salmonella typhimurium 3,400 nmol/plate (+/-enzymatic activation step) JPETAB 200,1,1977
mutation in microorganisms Saccharomyes cerevisiae 5,000 ppm (+enzymatic activation step) NTIS** PB80-133226
mutation in microorganisms Schizosaccharomyces pombe 20 mmol/L (+/-enzymatic activation step) MUREAV 117,139,1983
micronucleus test intraperitoneal
mouse
100 mg/kg MUREAV 471,37,2000
micronucleus test intravenous
mouse
225 mg/kg/6 day MUREAV 632,89,2007
gene conversion and mitotic recombination Saccharomyes cerevisiae 5,000 ppm NTIS** PB80-133226
mutation in mammalian somatic cells mouse lymphocyte 80 mg/L NTIS** PB84-138973
morphological transform mouse embryo 3 mg/L PMRSDJ 5,659,1985
other mutation test systems human lymphocyte 20 mg/L MUREAV 300,135,1993
sister chromatid exchange hamster lung 20 mg/L MUREAV 88,307,1981
sister chromatid exchange hamster ovary 2 gm/L NTIS** PB84-138973
sister chromatid exchange human lymphocyte 20 mg/L MUREAV 300,135,1993
sister chromatid exchange intraperitoneal
mouse
120 mg/kg MUREAV 300,135,1993
sex chromosome loss and nondisjunction intraperitoneal
mouse
100 mg/kg MUREAV 471,31,2000
sperm morphology unreported route
mouse
8,800 mg/kg/22 day- intermittent MUTAEX 20,469,2005


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 60 mg/kg (9 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death BIRUAA 13,238,1975
intraperitoneal
mouse
lowest published toxic dose: 206 mg/kg (2-5 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) EESADV 13,216,1987
oral
guinea pig
lowest published toxic dose: 600 mg/kg (36-53 day pregnant) Reproductive: Effects on fertility: Abortion

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system
ARTODN 59,30,1986
oral
guinea pig
lowest published toxic dose: 600 mg/kg (36-53 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Other neonatal measures or effects
ARTODN 59,30,1986
oral
hamster
lowest published toxic dose: 2 gm/kg (7-11 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Homeostasis
EVHPAZ 30,105,1979
oral
hamster
lowest published toxic dose: 2 gm/kg (7-11 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) EVHPAZ 30,105,1979
oral
hamster
lowest published toxic dose: 1,500 mg/kg (7-11 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) EVHPAZ 30,105,1979
oral
hamster
lowest published toxic dose: 400 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death EVHPAZ 30,105,1979
oral
mouse
lowest published toxic dose: 1,500 mg/kg (10-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) EVHPAZ 30,105,1979
oral
mouse
lowest published toxic dose: 1,800 mg/kg (12-14 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) EVHPAZ 30,105,1979
oral
mouse
lowest published toxic dose: 3 gm/kg (7-16 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system JPFCD2 21,207,1986
oral
mouse
lowest published toxic dose: 4 gm/kg (7-16 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
JPFCD2 21,207,1986
oral
mouse
lowest published toxic dose: 1,650 mg/kg (30 day prior to copulation/1-3 day pregnant) Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)

Reproductive: Other effects to embryo or fetus
TOXID9 -,234,2008
oral
rat
lowest published toxic dose: 78,400 g/kg (16-22 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic NUPOBT 17,135,1979
oral
rat
lowest published toxic dose: 80 mg/kg (13 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
EVHPAZ 13,121,1976
oral
rat
lowest published toxic dose: 80 mg/kg (9 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Homeostasis
EVHPAZ 13,121,1976
oral
rat
lowest published toxic dose: 1,450 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
EVHPAZ 13,133,1976
oral
rat
lowest published toxic dose: 750 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) EVHPAZ 13,133,1976
oral
rat
lowest published toxic dose: 2,200 g/kg (1-22 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) GISAAA 38(8),21,1973
oral
rat
lowest published toxic dose: 12,210 mg/kg (60 day male/14 day prior to copulation) Reproductive: Other effects on female

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
JESEDU 31,1141,1996
oral
rat
lowest published toxic dose: 26,327 mg/kg (multigeneration) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Biochemical and metabolic
REPTED 12,619,1998
oral
rabbit
lowest published toxic dose: 700 mg/kg (2-15 day pregnant) Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on embryo or fetus: Maternal- fetal exchange
RPTOAN 38,84,1975
subcutaneous
guinea pig
lowest published toxic dose: 375 mg/kg (42-44 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Other neonatal measures or effects
TXAPA9 219,128,2007
subcutaneous
guinea pig
lowest published toxic dose: 375 mg/kg (42-44 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic TXAPA9 219,128,2007
subcutaneous
guinea pig
lowest published toxic dose: 200 mg/kg (41 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TXAPA9 219,128,2007
unreported route
guinea pig
lowest published toxic dose: 375 mg/kg (42-44 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system NEREDZ 19,569,1994
unreported route
mouse
lowest published toxic dose: 4,200 mg/kg (1-21 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TJADAB 21,35A,1980


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intramuscular
rat
lowest published toxic dose: 183 mg/kg/6 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Tumors
ARGEAR 41,311,1973
oral
rat
lowest published toxic dose: 186 mg/kg/6 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Tumors
ARGEAR 41,311,1973
oral
rat
lowest published toxic dose: 11.250 mg/kg/75 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria EXONC* 14,36,1992
skin
rat
lowest published toxic dose: 1,950 mg/kg/22 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
ERNFA7 16,515,1972


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 1,710 g/m3/90 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase BJIMAG 43,414,1986
inhalation
rat
lethal concentration (50 percent kill): 1,300 mg/m3 N/R ARGEAR 48,112,1978
inhalation
rat
lethal concentration (50 percent kill): 1,300 mg/kg N/R ENTOX* -,377,2005
intramuscular
rat
lethal dose (50 percent kill): 395 mg/kg Cardiac: Other changes

Liver: Other changes

Blood: Hemorrhage
ARTODN 41,3,1978
intramuscular
rabbit
lowest published lethal dose: 500 mg/kg Vascular: Other changes

Lung, Thorax, or Respiration: Other changes

Blood: Hemorrhage
MDWTAG 35,479,1979
intraperitoneal
guinea pig
lethal dose (50 percent kill): 300 mg/kg N/R AMIHAB 11,53,1955
intraperitoneal
hamster
lethal dose (50 percent kill): 1 gm/kg N/R ARTODN 58,152,1986
intraperitoneal
mouse
lethal dose (50 percent kill): 196 mg/kg N/R TXAPA9 2,495,1960
intraperitoneal
mouse
lowest published toxic dose: 400 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Tremor

Behavioral: Ataxia
MUREAV 651,125,2008
intraperitoneal
mouse
lowest published toxic dose: 400 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
MUREAV 651,125,2008
intraperitoneal
rat
lethal dose (50 percent kill): 160 mg/kg N/R APCRAW 4,117,1961
intraperitoneal
rabbit
lethal dose (50 percent kill): 60 mg/kg Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands
AJOPAA 53,512,1962
intravenous
dog
lethal dose (50 percent kill): 150 mg/kg Cardiac: Other changes

Liver: Other changes

Blood: Hemorrhage
ARTODN 41,3,1978
intravenous
mouse
lethal dose (50 percent kill): 290 mg/kg Cardiac: Other changes

Liver: Other changes

Blood: Hemorrhage
ARTODN 41,3,1978
oral
wild bird
lethal dose (50 percent kill): 22.4 mg/kg N/R ENTOX* -,377,2005
oral
cat
lethal dose (50 percent kill): 97 mg/kg N/R ENTOX* -,377,2005
oral
chicken
lethal dose (50 percent kill): 75 mg/kg N/R EQSFAP 3,173,1974
oral
chicken
lowest published toxic dose: 80 mg/kg Brain and Coverings: Other degenerative changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOLED5 136,143,2002
oral
dog
lethal dose (50 percent kill): 400 mg/kg Cardiac: Other changes

Liver: Other changes

Blood: Hemorrhage
ARTODN 41,3,1978
oral
dog
lethal dose (50 percent kill): 400 mg/kg N/R ENTOX* -,377,2005
oral
guinea pig
lowest published lethal dose: 420 mg/kg Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
BUMMAB 9,7,1955
oral
guinea pig
lethal dose (50 percent kill): 420 mg/kg N/R ENTOX* -,377,2005
oral
monkey
lethal dose : >1 gm/kg Spinal Cord: Other degenerative changes

Gastrointestinal: Other changes

Musculoskeletal: Other changes
JOUOD4 5(Suppl),125,1983
oral
mouse
lethal dose (50 percent kill): 300 mg/kg N/R USXXAM #6365129
oral
mouse
lowest published toxic dose: 600 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Tremor

Behavioral: Ataxia
MUREAV 651,125,2008
oral
mouse
lowest published toxic dose: 600 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase MUREAV 651,125,2008
oral
quail
lethal dose (50 percent kill): 73,110 g/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Hypermotility, diarrhea
HOEKAN 24,35,1974
oral
rat
lethal dose (50 percent kill): 450 mg/kg N/R USXXAM #5006545
oral
rat
lethal dose (50 percent kill): 882.7 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase FATOAO 53,64,1990
oral
rat
lowest published toxic dose: 3 mg/kg Behavioral: Alteration of operant conditioning EURNE* 14,285,2003
oral
rat
lowest published toxic dose: 10 mg/kg Behavioral: Change in psychophysiological tests PSCHDL 172,375,2004
oral
rat
lowest published toxic dose: 10 mg/kg Behavioral: Alteration of classical conditioning PSCHDL 172,375,2004
oral
rabbit
lethal dose (50 percent kill): 160 mg/kg N/R ENTOX* -,377,2005
oral
woman
lowest published toxic dose: 1,364 L/kg Autonomic Nervous System: Ganglion blocker

Behavioral: General anesthetic

Behavioral: Sleep
RISHDJ 21,993,1981
oral
woman
lowest published toxic dose: 1 mL/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Muscle weakness

Behavioral: Coma
JOUOD4 5(Suppl),125,1983
oral
woman
lowest published toxic dose: 1,200 L/kg Spinal Cord: Other degenerative changes

Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Coma
JOUOD4 5(Suppl),125,1983
oral
woman
lowest published toxic dose: 240 mg/kg Spinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Coma
JOUOD4 5(Suppl),125,1983
subcutaneous
chicken
lethal dose (50 percent kill): 125 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) BCPCA6 12,1377,1963
subcutaneous
dog
lethal dose (50 percent kill): 269 mg/kg Behavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Other changes
RCCRDT 7(1),23,1977
subcutaneous
mouse
lethal dose (50 percent kill): 267 mg/kg N/R ARZNAD 31,555,1981
subcutaneous
rat
lethal dose (50 percent kill): 400 mg/kg N/R JEENAI 50,356,1957
skin
mammal (species unspecified)
lethal dose (50 percent kill): >2,800 mg/kg N/R ARTODN 41,3,1978
skin
mouse
lethal dose (50 percent kill): 1,710 mg/kg N/R YKYUA6 37,597,1986
skin
rat
lethal dose (50 percent kill): 2 gm/kg N/R ARGEAR 48,112,1978
skin
rabbit
lethal dose : >1,500 mg/kg Skin: After systemic exposure: Dermatitis, irritative

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GTPZAB 8(10),54,1964
unreported route
cat
lethal dose (50 percent kill): 98 mg/kg Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma

Lung, Thorax, or Respiration: Acute pulmonary edema
RPTOAN 50,61,1987
unreported route
mammal (species unspecified)
lethal dose (50 percent kill): 295 mg/kg N/R GISAAA 38(8),101,1973
unreported route
mouse
lethal dose (50 percent kill): 445 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase PCJOAU 3,508,1969
unreported route
rat
lethal dose (50 percent kill): 550 mg/kg N/R GTPZAB 26(6),21,1982
unreported route
rat
lowest published toxic dose: 110 mg/kg Behavioral: Tremor TXAPA9 197,366,2004


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 59 mg/m3/14 hour/80 day- intermittent Vascular: Regional or general arteriolar or venous dilation

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
GISAAA 32(12),13,1967
inhalation
rat
lowest published toxic concentration: 2 mg/m3/4 hour/17 week- intermittent Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GTPZAB 8(10),54,1964
intramuscular
rat
lowest published toxic dose: 2,000 mg/kg/5 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field FATOAO 50,97,1987
intraperitoneal
rat
lowest published toxic dose: 3 gm/kg/15 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve ARTODN 52,167,1983
intraperitoneal
rat
lowest published toxic dose: 6 gm/kg/60 day- intermittent Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMIHAB 11,53,1955
oral
dog
lowest published toxic dose: 1,050 mg/kg/12 week- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXAPA9 1,1,1959
oral
mouse
lowest published toxic dose: 2,100 mg/kg/14 day- continuous Liver: Changes in liver weight

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
ATDAEI 1,21,1990
oral
rat
lowest published toxic dose: 672 mg/kg/90 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) TOLED5 1000(Suppl 1),141,1980
oral
rat
lowest published toxic dose: 780 mg/kg/10 day- intermittent Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites
GISAAA 49(5),80,1984
oral
rat
lowest published toxic dose: 562 mg/kg/30 day- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
GISAAA 29(5),30,1964
subcutaneous
chicken
lowest published toxic dose: 300 mg/kg/5 day- intermittent Brain and Coverings: Demyelination

Behavioral: Ataxia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
EESADV 3,245,1979
unreported route
mouse
lowest published toxic dose: 8,800 mg/kg/22 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Related to Chronic Data: Changes in testicular weight
MUTAEX 20,469,2005


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 mg/m3 (inhalable) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 30,207,1983
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 30,207,1983
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
CRTXB2 3,289,1975
TOXICOLOGY REVIEW
RREVAH 46,1,1973
TOXICOLOGY REVIEW
MZUZA8 (8),90,1973
TOXICOLOGY REVIEW
CNDQA8 10(3),43,1975
TOXICOLOGY REVIEW
DTTIAF 80,485,1973
TOXICOLOGY REVIEW
RREVAH 63,1,1976
TOXICOLOGY REVIEW
EMMUEG 45,271,2005
TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
CCATAR 366,1,2006
TOXICOLOGY REVIEW
CCATAR 366,1,2006
TOXICOLOGY REVIEW
ENTOX* -,588,2005
TOXICOLOGY REVIEW
ENTOX* -,306,2005
TOXICOLOGY REVIEW
ENTOX* -,308,2005
TOXICOLOGY REVIEW
ENTOX* -,377,2005
TOXICOLOGY REVIEW
MUREAV 651,1,2008
TOXICOLOGY REVIEW
FEREAC 72,54574,2007
TOXICOLOGY REVIEW
FEREAC 72,28912,2007
TOXICOLOGY REVIEW
FEREAC 72,54574,2007
TOXICOLOGY REVIEW
FEREAC 72,28912,2007
TOXICOLOGY REVIEW
JTPAE7 19,1,2006
TOXICOLOGY REVIEW
ITODC* -,355,2004
TOXICOLOGY REVIEW
HUTOX* -,541,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,154,1998
Occupational Exposure Limit - BELGIUM time-weighted average 1 mg/m3, MAR2002
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.5 mg/m3, MAC(short term exposure limit) 2 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 mg/m3, Skin, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: T0248;
Number of Industries 1;
Total Number of Facilities 473;
Number of Occupations 1;
Total Number of Employees Exposed 9,450
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T0248;
Number of Industries 1;
Total Number of Facilities 19;
Number of Occupations 1;
Total Number of Employees Exposed 338;
Total Number of Female Employees Exposed 131


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: Body fluid assay; Host-mediated assay
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Weakly Positive: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Positive/dose response: TRP reversion
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus; B subtilis rec assay
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
Used as an agricultural and forest insecticide
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
APCRAW Advances in Pest Control Research. (New York, NY) V.1-18, 1957-68.
ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1949-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
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BIZNAT Biologisches Zentralblatt. (VEB Georg Thieme, Postfach 946, Leipzig DDR-7010, Ger. Dem. Rep.) V.1- 1881-
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DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EQSFAP Environmental Quality and Safety. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1972-76. Discontinued.
ERNFA7 Ernaehrungsforschung. (Akademie-Verlag GmbH, Leipziger St. 3-4, 108 Berlin, Ger. Dem. Rep.) V.1- 1956-
EURNE* European Neuropsychopharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Nov.1990-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
EXONC* Experimental Oncology (Journal of ucrainian section of European institute of ecology and cancer, Kiev-22, Vaselkovskaya str., 25, Kiev-22) V.1- 1979-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HOEKAN Hokkaidoritsu Eisei Kenkyushoho. Report of the Hokkaido Institute of Public Health. (Nishi- 12-chome, Kita-19-jo, Kita-ku, Sapporo 060, Japan) No.1- 1951-
HUTOX*
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
ITODC*
JEENAI Journal of Economic Entomology. (Entomological Soc. of America, 4603 Calvert Rd., College Park, MD 20740) V.1- 1908-
JESEDU Journal of Environmental Science and Health, Part A: Environmental Science and Engineering. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.A11- 1976-
JFIBA9 Journal of Fish Biology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1969-
JOUOD4 Journal of UOEH (University of Occupational and Environmental Health). (Univ. of Occupational and Environmental Health, 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu 807, Japan) V.1- 1979-
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RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
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Used as an agricultural and forest insecticide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

ALT CAS #: 66758-31-4
Click Here for Additional Information about RTECS

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