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Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphonic acid, (2,2,2-trichloro-1-hydroxyethyl)-, dimethyl ester

RTECS #

TA0700000

CAS #

52-68-6; 66758-31-4

Updated

September 201

Molecular Weight

257.44

Molecular Formula

C4H8Cl3O4P

Synonyms

((2,2,2-Trichloro-1-hydroxyethyl) dimethylphosphonate)
(2,2,2-Trichloro-1-hydroxyethyl)phosphonic acid dimethyl ester
1-Hydroxy-2,2,2-trichloro-ethyle phosphonate de dimethyle (French)
1-Hydroxy-2,2,2-trichloroethylphosphonic acid dimethyl ester
2,2,2-Trichloroethyl dimethyl phosphate
Aerol 1
Aerol 1 (pesticide)
Agroforotox
Anthon
BAY 15922
Bayer 15922
Bayer L 13/59
Bilarcil
Bovinox
Briton
Britten
Cekufon
Chlorak
Chlorfos
Chlorofos
Chloroftalm
Chlorophos
Chlorophose
Chlorophthalm
Chloroxyphos
Ciclosom
Combot
Combot equine
Danex
DEP (pesticide)
Depthon
DETF
Dimethoxy-2,2,2-trichloro-1-hydroxy-ethyl-phosphine oxide
Dimethyl 1-hydroxy-2,2,2-trichloroethyl phosphonate
Dimethyl 2,2,2-trichloro-1-hydroxyethylphosphonate
Dimethyltrichlorohydroxyethyl phosphonate
Dimetox
Dipterex
Dipterex 50
Diptevur
Ditrifon
Dylox
Dylox-metasystox-R
Dyrex
Dyvon
ENT 19,763
Equino-aid
Flibol E
Fliegenteller
Forotox
Foschlor
Foschlor 25
Foschlor R
Foschlor R-50
Foschlorem (Polish)
Hypodermacid
Leivasom
Loisol
Masoten
Mazoten
Methyl chlorophos
Metrifonate
Metriphonate
NCI-C54831
Neguvon
O,O Dimetil 2,2,2-trichloro 1 hidroxietil fosfonato (Portugese)
O,O-Dimethyl (1-hydroxy-2,2,2-trichloroethyl)phosphonate
O,O-Dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosponate
O,O-Dimethyl-(1-hydroxy-2,2,2-trichloraethyl)phosphonsaeure ester (German)
O,O-Dimethyl-(1-hydroxy-2,2,2-trichlorathyl)-phosphat (German)
O,O-Dimethyl-(1-hydroxy-2,2,2-trichloro)ethyl phosphate
O,O-Dimethyl-(2,2,2-trichloor-1-hydroxy-ethyl)-fosfonaat (Dutch)
O,O-Dimethyl-(2,2,2-trichlor-1-hydroxy-aethyl)phosphonat (German)
O,O-Dimethyl-1-oxy-2,2,2-trichloroethyl phosphonate
O,O-Dimetil-(2,2,2-tricloro-1-idrossi-etil)-fosfonato (Italian)
Phoschlor
Phoschlor R50
Phosphonic acid, (1-hydroxy-2,2,2-trichloroethyl)-, dimethyl ester
Polfoschlor
Proxol
Ricifon
Ritsifon
Satox 20WSC
Soldep
Sotipox
Trichloorfon (Dutch)
Trichlorfon
Trichlorfon (German)
Trichlorofon
Trichlorophon
Trichlorphon
Trichlorphon FN
Trinex
Tugon
Tugon fly bait
Tugon stable spray
Vermicide bayer 2349
Volfartol
Votexit
WEC 50
Wotexit

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 120 mg/6D- intermittent mildBUMMAB 9,7,1955

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
body fluid assaySalmonella typhimurium/mouse200 mg/kgCNREA8 38,4478,1978
Cytogenetic Analysisoral/mouse8500 µg/kgGISAAA 45(1),80,1980
Cytogenetic Analysisintraperitoneal/mouse51500 µg/kgEESADV 13,216,1987
Cytogenetic Analysislung/hamster81 mg/LGMCRDC 27,95,1981
Cytogenetic Analysisovary/mouse50 µg/plate/16HMUREAV 564,165,2004
Cytogenetic Analysisunreported route/mouse8800 mg/kg/22D- intermittentMUTAEX 20,469,2005
Cytogenetic Analysisovary/mouse50 mg/L/16HMUREAV 652,114,2008
Cytogenetic Analysismultiple/other fish1 µL/LJFIBA9 26,13,1985
Cytogenetic Analysisleukocyte/human40 mg/LHOEKAN 29,33,1979
Cytogenetic Analysisoral/mouse100 mg/kgSOGEBZ 11,1534,1975
DNA Damageintraperitoneal/mouse160 mg/kgPCBPBS 6,101,1976
DNA repair/Other microorganisms10 mg/plateBIZNAT 95,463,1976
Dominant Lethal Testintraperitoneal/mouse405 mg/kgARTODN 33,163,1975
gene conversion and mitotic recombination/Saccharomyes cerevisiae5000 ppmNTIS** PB80-133226
host-mediated assaySalmonella typhimurium/mouse50 mg/kgJPETAB 200,1,1977
micronucleus testintravenous/mouse225 mg/kg/6DMUREAV 632,89,2007
micronucleus testintraperitoneal/mouse100 mg/kgMUREAV 471,37,2000
morphological transformembryo/mouse3 mg/LPMRSDJ 5,659,1985
mutation in mammalian somatic cellslymphocyte/mouse80 mg/LNTIS** PB84-138973
mutation in microorganisms/Schizosaccharomyces pombe20 mmol/L (+/-enzymatic activation step)MUREAV 117,139,1983
mutation in microorganisms/Saccharomyes cerevisiae5000 ppm (+enzymatic activation step)NTIS** PB80-133226
mutation in microorganisms/Salmonella typhimurium3400 nmol/plate (+/-enzymatic activation step)JPETAB 200,1,1977
mutation in microorganisms/Escherichia coli8650 µg/plate (-enzymatic activation step)MUREAV 28,405,1975
mutation in microorganisms/Escherichia coli1 mg/plate (+enzymatic activation step)NTIS** PB80-133226
mutation in microorganisms/Other microorganisms4 mg/plate (-enzymatic activation step)CBINA8 22,297,1978
other mutation test systemslymphocyte/human20 mg/LMUREAV 300,135,1993
sex chromosome loss and nondisjunctionintraperitoneal/mouse100 mg/kgMUREAV 471,31,2000
sister chromatid exchangelung/hamster20 mg/LMUREAV 88,307,1981
sister chromatid exchangeovary/hamster2 gm/LNTIS** PB84-138973
sister chromatid exchangeintraperitoneal/mouse120 mg/kgMUREAV 300,135,1993
sister chromatid exchangelymphocyte/human20 mg/LMUREAV 300,135,1993
sperm morphologyunreported route/mouse8800 mg/kg/22D- intermittentMUTAEX 20,469,2005
Unscheduled DNA Synthesisother cell types/human4 mole/LPSSCBG 15,439,1984
Unscheduled DNA Synthesisfibroblast/human100 mg/LNTIS** PB80-133226

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse 60 mg/kg (9D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathBIRUAA 13,238,1975
intraperitoneal/mouse 206 mg/kg (2-5D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)EESADV 13,216,1987
oral/mouse 1650 mg/kg (30D prior to copulation/1-3D pregnant)Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)

Reproductive: Other effects to embryo or fetus
TOXID9 -,234,2008
oral/mouse 1500 mg/kg (27D prior to copulation/1-3D pregnant)Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)

Reproductive: Other effects to embryo or fetus
FCTOD7 49,2655,2011
oral/rat 78400 µg/kg (16-22D pregnant)Reproductive: Effects on newborn: Biochemical and metabolicNUPOBT 17,135,1979
oral/rat 80 mg/kg (13D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
EVHPAZ 13,121,1976
oral/rat 80 mg/kg (9D pregnant)Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Homeostasis
EVHPAZ 13,121,1976
oral/rat 1450 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
EVHPAZ 13,133,1976
oral/rat 750 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)EVHPAZ 13,133,1976
oral/rat 2200 µg/kg (1-22D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)GISAAA 38(8),21,1973
oral/rat 12210 mg/kg (60D male/14D prior to copulation)Reproductive: Other effects on female

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
JESEDU 31,1141,1996
oral/rat 26327 mg/kg (multigeneration)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Biochemical and metabolic
REPTED 12,619,1998
oral/mouse 1500 mg/kg (10-14D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)EVHPAZ 30,105,1979
oral/mouse 1800 mg/kg (12-14D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)EVHPAZ 30,105,1979
oral/mouse 3 gm/kg (7-16D pregnant)Reproductive: Specific developmental abnormalities: Urogenital systemJPFCD2 21,207,1986
oral/mouse 4 gm/kg (7-16D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
JPFCD2 21,207,1986
oral/rabbit 700 mg/kg (2-15D pregnant)Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on embryo or fetus: Maternal- fetal exchange
RPTOAN 38,84,1975
oral/guinea pig 600 mg/kg (36-53D pregnant)Reproductive: Effects on fertility: Abortion

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system
ARTODN 59,30,1986
oral/guinea pig 600 mg/kg (36-53D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Other neonatal measures or effects
ARTODN 59,30,1986
oral/hamster 2 gm/kg (7-11D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Homeostasis
EVHPAZ 30,105,1979
oral/hamster 2 gm/kg (7-11D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)EVHPAZ 30,105,1979
oral/hamster 1500 mg/kg (7-11D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)EVHPAZ 30,105,1979
oral/hamster 400 mg/kg (8D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathEVHPAZ 30,105,1979
subcutaneous/guinea pig 375 mg/kg (42-44D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Other neonatal measures or effects
TXAPA9 219,128,2007
subcutaneous/guinea pig 375 mg/kg (42-44D pregnant)Reproductive: Effects on newborn: Biochemical and metabolicTXAPA9 219,128,2007
subcutaneous/guinea pig 200 mg/kg (41D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TXAPA9 219,128,2007
unreported route/guinea pig 375 mg/kg (42-44D pregnant)Reproductive: Specific developmental abnormalities: Central nervous systemNEREDZ 19,569,1994
unreported route/mouse 4200 mg/kg (1-21D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemTJADAB 21,35A,1980

Tumorigenic Data and References

Route/OrganismDoseEffectReference
intramuscular/rat lowest published toxic dose: 183 mg/kg/6W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Tumors
ARGEAR 41,311,1973
oral/rat lowest published toxic dose: 11.250 mg/kg/75W- intermittentTumorigenic: Carcinogenic by RTECS criteriaEXONC* 14,36,1992
oral/rat lowest published toxic dose: 186 mg/kg/6W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Tumors
ARGEAR 41,311,1973
skin/rat lowest published toxic dose: 1950 mg/kg/22W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
ERNFA7 16,515,1972

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 1710 µg/m3/90D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseBJIMAG 43,414,1986
inhalation/rat lethal concentration (50 percent kill): 1300 mg/m3ARGEAR 48,112,1978
inhalation/rat lethal concentration (50 percent kill): 1300 mg/kgENTOX* -,377,2005
intramuscular/rabbit lowest published lethal dose: 500 mg/kgVascular: Other changes

Lung, Thorax, or Respiration: Other changes

Blood: Hemorrhage
MDWTAG 35,479,1979
intramuscular/rat lethal dose (50 percent kill): 395 mg/kgCardiac: Other changes

Liver: Other changes

Blood: Hemorrhage
ARTODN 41,3,1978
intraperitoneal/guinea pig lethal dose (50 percent kill): 300 mg/kgAMIHAB 11,53,1955
intraperitoneal/hamster lethal dose (50 percent kill): 1 gm/kgARTODN 58,152,1986
intraperitoneal/mouse lethal dose (50 percent kill): 196 mg/kgTXAPA9 2,495,1960
intraperitoneal/mouse lowest published toxic dose: 50 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseFCTOD7 50,1036,2012
intraperitoneal/mouse lowest published toxic dose: 400 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Tremor

Behavioral: Ataxia
MUREAV 651,125,2008
intraperitoneal/mouse lowest published toxic dose: 400 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
MUREAV 651,125,2008
intraperitoneal/rabbit lethal dose (50 percent kill): 60 mg/kgEye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands
AJOPAA 53,512,1962
intraperitoneal/rat lethal dose (50 percent kill): 160 mg/kgAPCRAW 4,117,1961
intravenous/Dog lethal dose (50 percent kill): 150 mg/kgCardiac: Other changes

Liver: Other changes

Blood: Hemorrhage
ARTODN 41,3,1978
intravenous/mouse lethal dose (50 percent kill): 290 mg/kgCardiac: Other changes

Liver: Other changes

Blood: Hemorrhage
ARTODN 41,3,1978
oral/cat lethal dose (50 percent kill): 97 mg/kgENTOX* -,377,2005
oral/chicken lethal dose (50 percent kill): 75 mg/kgEQSFAP 3,173,1974
oral/chicken lowest published toxic dose: 80 mg/kgBrain and Coverings: Other degenerative changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOLED5 136,143,2002
oral/Dog lethal dose (50 percent kill): 400 mg/kgENTOX* -,377,2005
oral/Dog lethal dose (50 percent kill): 400 mg/kgCardiac: Other changes

Liver: Other changes

Blood: Hemorrhage
ARTODN 41,3,1978
oral/guinea pig lethal dose (50 percent kill): 420 mg/kgENTOX* -,377,2005
oral/guinea pig lowest published lethal dose: 420 mg/kgLung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
BUMMAB 9,7,1955
oral/monkey Lethal dose: >1 gm/kgSpinal Cord: Other degenerative changes

Gastrointestinal: Other changes

Musculoskeletal: Other changes
JOUOD4 5(Suppl),125,1983
oral/mouse lowest published toxic dose: 600 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Tremor

Behavioral: Ataxia
MUREAV 651,125,2008
oral/mouse lowest published toxic dose: 600 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseMUREAV 651,125,2008
oral/mouse lethal dose (50 percent kill): 300 mg/kgUSXXAM #6365129
oral/quail lethal dose (50 percent kill): 73110 µg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Hypermotility, diarrhea
HOEKAN 24,35,1974
oral/rabbit lethal dose (50 percent kill): 160 mg/kgENTOX* -,377,2005
oral/rat lowest published toxic dose: 10 mg/kgBehavioral: Alteration of classical conditioningPSCHDL 172,375,2004
oral/rat lethal dose (50 percent kill): 450 mg/kgUSXXAM #5006545
oral/rat lowest published toxic dose: 3 mg/kgBehavioral: Alteration of operant conditioningEURNE* 14,285,2003
oral/rat lowest published toxic dose: 10 mg/kgBehavioral: Change in psychophysiological testsPSCHDL 172,375,2004
oral/rat lethal dose (50 percent kill): 882.7 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseFATOAO 53,64,1990
oral/wild bird lethal dose (50 percent kill): 22.4 mg/kgENTOX* -,377,2005
oral/woman lowest published toxic dose: 1364 µL/kgAutonomic Nervous System: Ganglion blocker

Behavioral: General anesthetic

Behavioral: Sleep
RISHDJ 21,993,1981
oral/woman lowest published toxic dose: 1 mL/kgAutonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Muscle weakness

Behavioral: Coma
JOUOD4 5(Suppl),125,1983
oral/woman lowest published toxic dose: 1200 µL/kgSpinal Cord: Other degenerative changes

Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Coma
JOUOD4 5(Suppl),125,1983
oral/woman lowest published toxic dose: 240 mg/kgSpinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Coma
JOUOD4 5(Suppl),125,1983
skin/mammal (species unspecified) lethal dose (50 percent kill): >2800 mg/kgARTODN 41,3,1978
skin/mouse lethal dose (50 percent kill): 1710 mg/kgYKYUA6 37,597,1986
skin/rabbit Lethal dose: >1500 mg/kgSkin: After systemic exposure: Dermatitis, irritative

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GTPZAB 8(10),54,1964
skin/rat lethal dose (50 percent kill): 2 gm/kgARGEAR 48,112,1978
subcutaneous/chicken lethal dose (50 percent kill): 125 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)BCPCA6 12,1377,1963
subcutaneous/Dog lethal dose (50 percent kill): 269 mg/kgBehavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Other changes
RCCRDT 7(1),23,1977
subcutaneous/mouse lethal dose (50 percent kill): 267 mg/kgARZNAD 31,555,1981
subcutaneous/rat lethal dose (50 percent kill): 400 mg/kgJEENAI 50,356,1957
Tank with water/Daphnia lethal concentration (50 percent kill): 0.29 µg/L/48HBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)TIVIEQ 103,191,2011
Tank with water/Zebrafish lethal concentration (50 percent kill): 58.4 mg/L/48HBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)TIVIEQ 103,191,2011
Tank with water/Zebrafish lethal concentration (50 percent kill): 43.8 mg/L/72HBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)TIVIEQ 103,191,2011
Tank with water/Zebrafish lethal concentration (50 percent kill): 28.8 mg/L/96HBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)TIVIEQ 103,191,2011
unreported route/cat lethal dose (50 percent kill): 98 mg/kgLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma

Lung, Thorax, or Respiration: Acute pulmonary edema
RPTOAN 50,61,1987
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 295 mg/kgGISAAA 38(8),101,1973
unreported route/mouse lethal dose (50 percent kill): 445 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterasePCJOAU 3,508,1969
unreported route/rat lethal dose (50 percent kill): 550 mg/kgGTPZAB 26(6),21,1982
unreported route/rat lowest published toxic dose: 110 mg/kgBehavioral: TremorTXAPA9 197,366,2004

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 59 mg/m3/14H/80D- intermittentVascular: Regional or general arteriolar or venous dilation

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
GISAAA 32(12),13,1967
inhalation/rat lowest published toxic concentration: 2 mg/m3/4H/17W- intermittentKidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GTPZAB 8(10),54,1964
intramuscular/rat lowest published toxic dose: 2000 mg/kg/5D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldFATOAO 50,97,1987
intraperitoneal/rat lowest published toxic dose: 3 gm/kg/15D- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerveARTODN 52,167,1983
intraperitoneal/rat lowest published toxic dose: 6 gm/kg/60D- intermittentBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMIHAB 11,53,1955
oral/Dog lowest published toxic dose: 1050 mg/kg/12W- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTXAPA9 1,1,1959
oral/mouse lowest published toxic dose: 2100 mg/kg/14D- continuousLiver: Changes in liver weight

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
ATDAEI 1,21,1990
oral/rat lowest published toxic dose: 672 mg/kg/90D- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)TOLED5 1000(Suppl 1),141,1980
oral/rat lowest published toxic dose: 780 mg/kg/10D- intermittentBiochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites
GISAAA 49(5),80,1984
oral/rat lowest published toxic dose: 562 mg/kg/30D- intermittentBrain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
GISAAA 29(5),30,1964
oral/rat lowest published toxic dose: 11.37 mg/kg/26W- continuousGastrointestinal: Other changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOVEFN (2),29,2008
subcutaneous/chicken lowest published toxic dose: 300 mg/kg/5D- intermittentBrain and Coverings: Demyelination

Behavioral: Ataxia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
EESADV 3,245,1979
unreported route/mouse lowest published toxic dose: 8800 mg/kg/22D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Related to Chronic Data: Changes in testicular weight
MUTAEX 20,469,2005

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1 mg/m3 (inhal)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 30,207,1983
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 30,207,1983
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
TOXICOLOGY REVIEWCRTXB2 3,289,1975
TOXICOLOGY REVIEWRREVAH 46,1,1973
TOXICOLOGY REVIEWMZUZA8 (8),90,1973
TOXICOLOGY REVIEWCNDQA8 10(3),43,1975
TOXICOLOGY REVIEWDTTIAF 80,485,1973
TOXICOLOGY REVIEWRREVAH 63,1,1976
TOXICOLOGY REVIEWEMMUEG 45,271,2005
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWCCATAR 366,1,2006
TOXICOLOGY REVIEWENTOX* -,588,2005
TOXICOLOGY REVIEWENTOX* -,306,2005
TOXICOLOGY REVIEWENTOX* -,308,2005
TOXICOLOGY REVIEWENTOX* -,377,2005
TOXICOLOGY REVIEWMUREAV 651,1,2008
TOXICOLOGY REVIEWFEREAC 72,54574,2007
TOXICOLOGY REVIEWFEREAC 72,28912,2007
TOXICOLOGY REVIEWJTPAE7 19,1,2006
TOXICOLOGY REVIEWITODC* -,355,2004
TOXICOLOGY REVIEWHUTOX* -,541,1996
TOXICOLOGY REVIEWHETOEA 26,321,2007
TOXICOLOGY REVIEWMUTAEX 26,223,2011

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,154,1998
Occupational Exposure Limit-BELGIUMtime-weighted average 1 mg/m3, MAR2002
Occupational Exposure Limit-FINLANDtime-weighted average 0.5 mg/m3, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 2 mg/m3, skin, MAY2012
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.5 mg/m3, MAC(short term exposure limit) 2 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.5 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code T0248; Number of Industries 1; Total Number of Facilities 19; Number of Occupations 1; Total Number of Employees Exposed 338; Total Number of Female Employees Exposed 131
National Occupational Hazard Survey 1974Hazard Code T0248; Number of Industries 1; Total Number of Facilities 473; Number of Occupations 1; Total Number of Employees Exposed 9450

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus; B subtilis rec assay
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive/dose response: TRP reversion
EPA GENETOX PROGRAM 1988, Positive: Body fluid assay; Host-mediated assay
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Weakly Positive: In vitro UDS-human fibroblast
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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