Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphonic acid, dimethyl ester

RTECS #

SZ7710000

CAS #

868-85-9

Updated

December 2013

Molecular Weight

110.06

Molecular Formula

C2H7O3P

Synonyms

Bis(hydroxymethyl)phosphine oxide
Dimethoxyphosphine oxide
Dimethyl acid phosphite
Dimethyl hydrogen phosphite
Dimethyl hydrogen phosphonate
Dimethyl phosphite
Dimethyl phosphonate
Dimethyl phosphorous acid
Dimethylester kyseliny fosforite (Czech)
Dimethylfosfit (Czech)
Dimethylfosfonat (Czech)
Dimethylhydrogenphosphite
Hydrogen dimethyl phosphite
Methyl phosphonate ((MeO)2HPO)
NCI-C54773
Phosphorous acid dimethyl ester

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 20 mg/24H moderate85JCAE -,1115,1986
skin /rabbit 500 mg/24H mild85JCAE -,1115,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster1600 mg/LSCIEAS 236,933,1987
micronucleus testintraperitoneal/mouse1500 mg/kg/3D-continuousEMMUEG 21,160,1993
mutation in mammalian somatic cellslymphocyte/mouse2100 mg/LEMMUEG 11,91,1988
mutation in microorganisms/Salmonella typhimurium7500 µg/plate (-enzymatic activation step)ENMUDM 8(Suppl 7),1,1986
mutation in microorganismslymphocyte/mouse1700 mg/L (+enzymatic activation step)SCIEAS 236,933,1987
mutation in microorganisms/Salmonella typhimurium500 mg/L/2H (+enzymatic activation step)EMMUEG 44,329,2004
sister chromatid exchangeovary/hamster250 mg/LSCIEAS 236,933,1987

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 103 gm/kg/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Gastrointestinal: Tumors
NTPTR* NTP-TR-287,1985
oral/rat lowest published toxic dose: 144200 mg/kg/103W- continuousTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Gastrointestinal: Tumors
NTIS** PB86-144805/AS
oral/rat lowest published toxic dose: 72100 mg/kg/103W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
NTIS** PB86-144805/AS

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig Lethal concentration: >7100 mg/m3/6HLung, Thorax, or Respiration: Other changes

Blood: Hemorrhage
NTIS** OTS0537047
inhalation/mouse Lethal concentration: >7100 mg/m3/6HEye: Ptosis

Lung, Thorax, or Respiration: Dyspnea
NTIS** OTS0537047
inhalation/rat lethal concentration (50 percent kill): >20 gm/m3ALBRW* #OPB-3,1984
oral/guinea pig lethal dose (50 percent kill): 900 mg/kgAutonomic Nervous System: Other (direct) parasympathomimetic

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Changes in structure or function of salivary glands
GTPZAB 36(4),22,1992
oral/mouse lethal dose (50 percent kill): 1831 mg/kgAutonomic Nervous System: Other (direct) parasympathomimetic

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Changes in structure or function of salivary glands
GTPZAB 36(4),22,1992
oral/rat lethal dose (50 percent kill): 3040 mg/kgNTPTR* NTP-TR-287,1985
skin/rabbit lethal dose (50 percent kill): 681 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
NTIS** OTS0537044
subcutaneous/mouse lethal dose (50 percent kill): 2610 mg/kgGTPZAB 36(4),22,1992
subcutaneous/rat lethal dose (50 percent kill): 2970 mg/kgGTPZAB 36(4),22,1992

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 30 gm/kg/15D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-287,1985
oral/mouse lowest published toxic dose: 97500 mg/kg/13W- intermittentLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-287,1985
oral/rat lowest published toxic dose: 7500 mg/kg/15D- intermittentBehavioral: Somnolence (general depressed activity)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-287,1985
oral/rat lowest published toxic dose: 26 gm/kg/13W- intermittentEye: Corneal damage

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-287,1985

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 48,85,1990
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 71,1437,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 71,1437,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 71,1437,1999
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 726,91,2011
TOXICOLOGY REVIEWMUREAV 746,89,2012

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.5 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84136; Number of Industries 1; Total Number of Facilities 7; Number of Occupations 1; Total Number of Employees Exposed 1822; Total Number of Female Employees Exposed 272
National Occupational Hazard Survey 1974Hazard Code 84136; Number of Industries 1; Total Number of Facilities 21; Number of Occupations 2; Total Number of Employees Exposed 41

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);clear evidence:rat
NCI Carcinogenesis Studies (gavage);no evidence:mouse
TOP