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Phosphonic acid, dimethyl ester

RTECS #: SZ7710000

CAS #: 868-85-9

UPDATE: November 2007 MW: 110.06 MF: C2H7O3P


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Bis (hydroxymethyl) phosphine oxide
  2. Dimethoxyphosphine oxide
  3. Dimethyl acid phosphite
  4. Dimethyl hydrogen phosphite
  5. Dimethyl hydrogen phosphonate
  6. Dimethyl phosphite
  7. Dimethyl phosphonate
  8. Dimethyl phosphorous acid
  1. Dimethylester kyseliny fosforite (Czech)
  2. Dimethylfosfit (Czech)
  3. Dimethylfosfonat (Czech)
  4. Dimethylhydrogenphosphite
  5. Hydrogen dimethyl phosphite
  6. Methyl phosphonate ( (MeO) 2HPO)
  7. NCI - C54773
  8. Phosphorous acid dimethyl ester


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		20 mg/24 hour moderate 85JCAE -,1115,1986
skin
rabbit 		500 mg/24 hour mild 85JCAE -,1115,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 1,600 mg/L SCIEAS 236,933,1987
mutation in microorganisms mouse lymphocyte 1,700 mg/L (+enzymatic activation step) SCIEAS 236,933,1987
mutation in microorganisms Salmonella typhimurium 7,500 µg/plate (-enzymatic activation step) ENMUDM 8(Suppl 7),1,1986
mutation in microorganisms Salmonella typhimurium 500 mg/L/2 hour (+enzymatic activation step) EMMUEG 44,329,2004
micronucleus test intraperitoneal
mouse 		1,500 mg/kg/3 day- continuous EMMUEG 21,160,1993
mutation in mammalian somatic cells mouse lymphocyte 2,100 mg/L EMMUEG 11,91,1988
sister chromatid exchange hamster ovary 250 mg/L SCIEAS 236,933,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 103 gm/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Gastrointestinal: Tumors 		NTPTR* NTP-TR-287,1985
oral
rat 		lowest published toxic dose: 144,200 mg/kg/103 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Gastrointestinal: Tumors 		NTIS** PB86-144805/AS
oral
rat 		lowest published toxic dose: 72,100 mg/kg/103 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		NTIS** PB86-144805/AS


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lethal concentration : >7,100 mg/m3/6 hour Lung, Thorax, or Respiration: Other changes

Blood: Hemorrhage 		NTIS** OTS0537047
inhalation
mouse 		lethal concentration : >7,100 mg/m3/6 hour Eye: Ptosis

Lung, Thorax, or Respiration: Dyspnea 		NTIS** OTS0537047
inhalation
rat 		lethal concentration (50 percent kill): >20 gm/m3 N/R ALBRW* #OPB-3,1984
oral
guinea pig 		lethal dose (50 percent kill): 900 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Changes in structure or function of salivary glands 		GTPZAB 36(4),22,1992
oral
mouse 		lethal dose (50 percent kill): 1,831 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Changes in structure or function of salivary glands 		GTPZAB 36(4),22,1992
oral
rat 		lethal dose (50 percent kill): 3,040 mg/kg N/R NTPTR* NTP-TR-287,1985
subcutaneous
mouse 		lethal dose (50 percent kill): 2,610 mg/kg N/R GTPZAB 36(4),22,1992
subcutaneous
rat 		lethal dose (50 percent kill): 2,970 mg/kg N/R GTPZAB 36(4),22,1992
skin
rabbit 		lethal dose (50 percent kill): 681 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia 		NTIS** OTS0537044


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 30 gm/kg/15 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-287,1985
oral
mouse 		lowest published toxic dose: 97,500 mg/kg/13 week- intermittent Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-287,1985
oral
rat 		lowest published toxic dose: 7,500 mg/kg/15 day- intermittent Behavioral: Somnolence (general depressed activity)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-287,1985
oral
rat 		lowest published toxic dose: 26 gm/kg/13 week- intermittent Eye: Corneal damage

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-287,1985


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 48,85,1990
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 71,1437,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1437,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,1437,1999
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 mg/m3, Skin, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84136;
Number of Industries 1;
Total Number of Facilities 21;
Number of Occupations 2;
Total Number of Employees Exposed 41
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84136;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 1;
Total Number of Employees Exposed 1,822;
Total Number of Female Employees Exposed 272


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as flame retardant and chemical intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);clear evidence:rat
NCI Carcinogenesis Studies (gavage);no evidence:mouse


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ALBRW* Albright & Wilson Inc. (P.O. Box 26229, Richmond, VA 23260-6229)
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-

Used as flame retardant and chemical intermediate

RTECS Compound Description:
   Tumorigen
   Mutagen
   Primary Irritant

 Click Here for Additional Information about RTECS

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