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Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphine, triphenyl-

RTECS #

SZ3500000

CAS #

603-35-0

Updated

July 2013

Molecular Weight

262.30

Molecular Formula

C18H15P

Synonyms

PP 360
Trifenylfosfin (Czech)
Triphenylphosphane
Triphenylphosphide
Triphenylphosphine
Triphenylphosphorus

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg/24H mild85JCAE -,1114,1986
skin /rabbit 500 mg/24H mild85JCAE -,1114,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 1135 ppm/4HEye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AIHAM* -,-,1969
intramuscular/rat lethal dose (50 percent kill): 1500 mg/kgBehavioral: Convulsions or effect on seizure thresholdEPASR* 8EHQ-0384-0014
oral/chicken lowest published lethal dose: 9 gm/kgBehavioral: Convulsions or effect on seizure thresholdEPASR* 8EHQ-0384-0014
oral/Dog lethal dose (50 percent kill): >500 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
NTIS** OTS0570648
oral/mouse lethal dose (50 percent kill): 1 gm/kgBehavioral: Convulsions or effect on seizure thresholdEPASR* 8EHQ-0384-0014
oral/rat lethal dose (50 percent kill): 700 mg/kgBehavioral: Convulsions or effect on seizure thresholdEPASR* 8EHQ-0384-0014
skin/rabbit lethal dose (50 percent kill): >5 gm/kgTXAPA9 28,313,1974
subcutaneous/mouse lethal dose (50 percent kill): 3 gm/kgBehavioral: Convulsions or effect on seizure thresholdEPASR* 8EHQ-0384-0014

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lowest published toxic concentration: 94500 µg/m3/6H/4W- intermittentBehavioral: Change in motor activity (specific assay)NTIS** OTS0570648
oral/Dog lowest published toxic dose: 950 mg/kg/14D- intermittentSpinal Cord: Other degenerative changes

Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
NTIS** OTS0570648
oral/Dog lowest published toxic dose: 525 mg/kg/21D- intermittentSpinal Cord: Demyelination

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
NTIS** OTS0570648

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-GERMANYMAK 5 mg/m3, inhal, skin sen, 2011
Occupational Exposure Limit-SWITZERLANDMAK-week 5 mg/m3, KZG-week 10 mg/m3, inhal, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X4096; Number of Industries 13; Total Number of Facilities 268; Number of Occupations 18; Total Number of Employees Exposed 14258; Total Number of Female Employees Exposed 1373

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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