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p - Phenylenediamine, dihydrochloride

RTECS #: ST0350000

CAS #: 624-18-0


UPDATE: May 2008 MW: 181.08 MF: C6H8N22ClH


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 1,4 - Benzenediamine dihydrochloride
  2. 1,4 - Diaminobenzene dihydrochloride
  3. 1,4 - Phenylenediamine dihydrochloride
  4. 4 - Aminoaniline dihydrochloride
  5. C.I. 76061
  6. C.I. Oxidation Base 10A
  7. Durafur Black RC
  8. Fourrine 64
  9. Fourrine DS
  10. NCI - C03930
  1. Oxidation Base 10A
  2. Pelagol CD
  3. Pelagol Grey CD
  4. p - Aminoaniline dihydrochloride
  5. p - Benzenediamine dihydrochloride
  6. p - Diaminobenzene dihydrochloride
  7. p - PD HCl
  8. p - Pda HCl
  9. p - Phenylenediamine hydrochloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Escherichia coli 333 g/plate (+enzymatic activation step) ENMUDM 7(Suppl 5),1,1985
mutation in microorganisms mouse lymphocyte 31,300 g/L (+enzymatic activation step) EMMUEG 12(Suppl 13),103,1988
mutation in microorganisms Salmonella typhimurium 33,300 ng/plate (-enzymatic activation step) ENMUDM 7(Suppl 5),1,1985
mutation in microorganisms Salmonella typhimurium 625 g/plate (+enzymatic activation step) MUREAV 608,58,2006
micronucleus test human lymphocyte 50 mg/L/20 hour (-enzymatic activation step) MUREAV 608,58,2006
micronucleus test human lymphocyte 400 mg/L/3 hour (+enzymatic activation step) MUREAV 608,58,2006
mutation in mammalian somatic cells human lymphocyte 20 mg/L MUREAV 196,61,1988
mutation in mammalian somatic cells mouse lymphocyte 1,250 g/L EMMUEG 12(Suppl 13),103,1988
specific locus test oral
Drosophila melanogaster
500 mol/L MUREAV 341,161,1995


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lethal dose (50 percent kill): 316 mg/kg N/R NCILB* NCI-E-C-72-3252,1973
oral
rat
lethal dose (50 percent kill): 147 mg/kg N/R NCILB* NCI-E-C-72-3252,1973
subcutaneous
dog
lowest published lethal dose: 10 mg/kg N/R XPHBAO 271,42,1941
subcutaneous
frog
lowest published lethal dose: 10 mg/kg N/R XPHBAO 271,42,1941
subcutaneous
mouse
lowest published lethal dose: 50 mg/kg N/R XPHBAO 271,42,1941
subcutaneous
rabbit
lowest published lethal dose: 20 mg/kg N/R XPHBAO 271,42,1941


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 16,125,1978
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 0.05 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as an analytical reagent in the testing of blood, HYDROGEN SULFIDE, milk
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat NCITR* NCI-TR-174,1979


REFERENCES:

CODEN
REFERENCE

EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCILB* Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to the National Cancer Institute by Litton Bionetics, Inc. (Bethesda, MD)
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
XPHBAO U.S. Public Health Service, Public Health Bulletin. (Washington, DC)

Used as an analytical reagent in the testing of blood, HYDROGEN SULFIDE, milk

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data

Click Here for Additional Information about RTECS

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