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Registry of Toxic Effects of Chemical Substances (RTECS)

p-Phenylenediamine, dihydrochloride

RTECS #

ST0350000

CAS #

624-18-0

Updated

December 2013

Molecular Weight

181.08

Molecular Formula

C6H8N2·2ClH

Synonyms

1,4-Benzenediamine dihydrochloride
1,4-Diaminobenzene dihydrochloride
1,4-Phenylenediamine dihydrochloride
4-Aminoaniline dihydrochloride
C.I. 76061
C.I. Oxidation Base 10A
Durafur Black RC
Fourrine 64
Fourrine DS
NCI-C03930
Oxidation Base 10A
p-Aminoaniline dihydrochloride
p-Benzenediamine dihydrochloride
p-Diaminobenzene dihydrochloride
Pelagol CD
Pelagol Grey CD
p-PD HCl
p-Pda HCl
p-Phenylenediamine hydrochloride

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
micronucleus testlymphocyte/human50 mg/L/20H (-enzymatic activation step)MUREAV 608,58,2006
micronucleus testlymphocyte/human400 mg/L/3H (+enzymatic activation step)MUREAV 608,58,2006
mutation in mammalian somatic cellslymphocyte/mouse1250 µg/LEMMUEG 12(Suppl 13),103,1988
mutation in mammalian somatic cellslymphocyte/human20 mg/LMUREAV 196,61,1988
mutation in microorganismslymphocyte/mouse31300 µg/L (+enzymatic activation step)EMMUEG 12(Suppl 13),103,1988
mutation in microorganisms/Salmonella typhimurium33300 ng/plate (-enzymatic activation step)ENMUDM 7(Suppl 5),1,1985
mutation in microorganisms/Escherichia coli333 µg/plate (+enzymatic activation step)ENMUDM 7(Suppl 5),1,1985
mutation in microorganisms/Salmonella typhimurium625 µg/plate (+enzymatic activation step)MUREAV 608,58,2006
specific locus testoral/Drosophila melanogaster500 µmol/LMUREAV 341,161,1995

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 6.1 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
oral/mouse lethal dose (50 percent kill): 316 mg/kgNCILB* NCI-E-C-72-3252,1973
oral/rat lethal dose (50 percent kill): 147 mg/kgNCILB* NCI-E-C-72-3252,1973
subcutaneous/Dog lowest published lethal dose: 10 mg/kgXPHBAO 271,42,1941
subcutaneous/frog lowest published lethal dose: 10 mg/kgXPHBAO 271,42,1941
subcutaneous/mouse lowest published lethal dose: 50 mg/kgXPHBAO 271,42,1941
subcutaneous/rabbit lowest published lethal dose: 20 mg/kgXPHBAO 271,42,1941

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 16,125,1978
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUTAEX 23,271,2008
TOXICOLOGY REVIEWMUREAV 726,91,2011
TOXICOLOGY REVIEWMUREAV 746,89,2012

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-FINLANDtime-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, skin, NOV2011
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.05 mg/m3, JUN2003

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,ratNCITR* NCI-TR-174,1979
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