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p - Phenylenediamine, N - phenyl -

RTECS #: ST3150000

CAS #: 101-54-2


UPDATE: February 2008 MW: 184.26 MF: C12H12N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,4 - Benzenediamine, N - phenyl - (9CI)
  2. 4 - Aminodiphenylamine
  3. Acna Black DF Base
  4. Azosalt R
  5. C.I. 37240
  6. C.I. 76085
  7. C.I. Azoic Diazo Component 22
  8. C.I. Developer 15
  9. C.I. Oxidation Base 2
  10. Diphenylamine, p - amino -
  11. Diphenylamine, 4 - amino -
  12. Diphenyl Black
  13. Fast Blue R Salt
  14. Luxan Black R
  15. N - Fenyl - p - fenylendiamin (Czech)
  1. N - Phenyl - p - aminoaniline
  2. N - Phenyl - 1,4 - benzenediamine
  3. N - Phenyl - p - phenylenediamine
  4. NCI - C02233
  5. Naphthoelan Navy Blue
  6. Oxy Acid Black Base
  7. Peltol BR
  8. Peltol BR II
  9. Rodol Gray B base
  10. Variamine Blue Salt RT
  11. p - Aminodifenylamin (Czech)
  12. p - Aminodiphenylamine
  13. p - Anilinoaniline
  14. p - Semidine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 mg/24 hour moderate 85JCAE -,481,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 150 g/plate (-enzymatic activation step) ESKHA5 (94),28,1976


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 1,500 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TOXID9 12,103,1992
oral
rat
lowest published toxic dose: 1,000 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TOXID9 12,103,1992
oral
rat
lowest published toxic dose: 1,000 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TOXID9 12,103,1992


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
cat
lowest published lethal dose: 100 mg/kg Lung, Thorax, or Respiration: Cyanosis

Blood: Methemoglobinemia- Carboxhemoglobinemia
JACTDZ 13,374,1994
oral
mouse
lethal dose (50 percent kill): 244 mg/kg Blood: Hemorrhage

Nutritional and Gross Metabolic: Body temperature decrease
TPKVAL 8,126,1966
oral
mouse
lethal dose : 200 mg/kg N/R TPKVAL 8,126,1966
oral
mouse
lethal dose (50 percent kill): 250 mg/kg Blood: Methemoglobinemia- Carboxhemoglobinemia TPKVAL 8,126,1966
oral
mouse
lethal dose : 350 mg/kg Behavioral: General anesthetic

Vascular: Other changes

Gastrointestinal: Other changes
TPKVAL 8,126,1966
oral
mouse
lethal dose (16 percent kill): 164.1 mg/kg Liver: Other changes

Nutritional and Gross Metabolic: Body temperature decrease
TPKVAL 8,126,1966
oral
mouse
lethal dose : 1,000 mg/kg Blood: Methemoglobinemia- Carboxhemoglobinemia TPKVAL 8,126,1966
oral
rat
lethal dose (50 percent kill): 464 mg/kg N/R NCILB* NCI-E-C-72-3252,1973
oral
rat
lowest published toxic dose: 2,211 mg/kg Vascular: Other changes

Liver: Fatty liver degeneration

Blood: Methemoglobinemia- Carboxhemoglobinemia
TPKVAL 14,118,1975
oral
rat
lowest published lethal dose: 250 mg/kg Brain and Coverings: Changes in circulation

Behavioral: Muscle contraction or spasticity

Vascular: Other changes
TPKVAL 8,126,1966
oral
rat
lethal dose : 350 mg/kg N/R TPKVAL 8,126,1966
oral
rat
lethal dose : 1,000 mg/kg Brain and Coverings: Changes in circulation

Behavioral: General anesthetic

Vascular: Other changes
TPKVAL 8,126,1966
oral
rabbit
lethal dose (50 percent kill): >5 gm/kg N/R JACTDZ 13,374,1994
skin
rabbit
lethal dose (50 percent kill): >5 gm/kg Olfaction: Other olfaction effects

Eye: Other eye effects

Behavioral: Food intake (animal)
ATDAEI 1,63,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 13,500 mg/kg/90 day- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
VHTODE 28,219,1986
oral
rat
lowest published toxic dose: 1,500 mg/kg/10 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOXID9 12,103,1992
oral
rat
lowest published toxic dose: 1,000 mg/kg/10 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOXID9 12,103,1992
oral
rat
lowest published toxic dose: 1,500 mg/kg/10 day- intermittent Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOXID9 12,103,1992


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
CMSHAF 53,809,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83649;
Number of Industries 4;
Total Number of Facilities 211;
Number of Occupations 20;
Total Number of Employees Exposed 7,379
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83649;
Number of Industries 4;
Total Number of Facilities 63;
Number of Occupations 11;
Total Number of Employees Exposed 4,356;
Total Number of Female Employees Exposed 530


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative/limited: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a dye, pigment and printing ink
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat NCITR* NCI-TR-82,1978


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972-
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
NCILB* Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to the National Cancer Institute by Litton Bionetics, Inc. (Bethesda, MD)
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-

Used as a dye, pigment and printing ink

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Primary Irritant

Click Here for Additional Information about RTECS

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