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Registry of Toxic Effects of Chemical Substances (RTECS)

p-Phenylenediamine, N-phenyl-

RTECS #

ST3150000

CAS #

101-54-2

Updated

April 2012

Molecular Weight

184.26

Molecular Formula

C12H12N2

Synonyms

1,4-Benzenediamine, N-phenyl- (9CI)
4-Aminodiphenylamine
Acna Black DF Base
Azosalt R
C.I. 37240
C.I. 76085
C.I. Azoic Diazo Component 22
C.I. Developer 15
C.I. Oxidation Base 2
Diphenyl Black
Diphenylamine, 4-amino-
Diphenylamine, p-amino-
Fast Blue R Salt
Luxan Black R
Naphthoelan Navy Blue
NCI-C02233
N-Fenyl-p-fenylendiamin (Czech)
N-Phenyl-1,4-benzenediamine
N-Phenyl-p-aminoaniline
N-Phenyl-p-phenylenediamine
Oxy Acid Black Base
p-Aminodifenylamin (Czech)
p-Aminodiphenylamine
p-Anilinoaniline
Peltol BR
Peltol BR II
p-Semidine
Rodol Gray B base
Variamine Blue Salt RT

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg/24H moderate85JCAE -,481,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damagemammary gland/human100 µmol/L/2.5HTXAPA9 232,169,2008
mutation in microorganisms/Salmonella typhimurium150 µg/plate (-enzymatic activation step)ESKHA5 (94),28,1976

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 1500 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TOXID9 12,103,1992
oral/rat 1000 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TOXID9 12,103,1992
oral/rat 1000 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TOXID9 12,103,1992

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/cat lowest published lethal dose: 100 mg/kgLung, Thorax, or Respiration: Cyanosis

Blood: Methemoglobinemia- Carboxhemoglobinemia
JACTDZ 13,374,1994
oral/mouse lethal dose (50 percent kill): 244 mg/kgBlood: Hemorrhage

Nutritional and Gross Metabolic: Body temperature decrease
TPKVAL 8,126,1966
oral/mouse lethal dose (50 percent kill): 250 mg/kgBlood: Methemoglobinemia- CarboxhemoglobinemiaTPKVAL 8,126,1966
oral/mouse lethal dose (16 percent kill): 164.1 mg/kgLiver: Other changes

Nutritional and Gross Metabolic: Body temperature decrease
TPKVAL 8,126,1966
oral/mouse lowest published lethal dose: 1000 mg/kgBlood: Methemoglobinemia- CarboxhemoglobinemiaTPKVAL 8,126,1966
oral/mouse lowest published lethal dose: 350 mg/kgBehavioral: General anesthetic

Vascular: Other changes

Gastrointestinal: Other changes
TPKVAL 8,126,1966
oral/mouse lowest published lethal dose: 200 mg/kgTPKVAL 8,126,1966
oral/rabbit lethal dose (50 percent kill): >5 gm/kgJACTDZ 13,374,1994
oral/rat lowest published toxic dose: 2211 mg/kgVascular: Other changes

Liver: Fatty liver degeneration

Blood: Methemoglobinemia- Carboxhemoglobinemia
TPKVAL 14,118,1975
oral/rat lowest published lethal dose: 350 mg/kgTPKVAL 8,126,1966
oral/rat lowest published lethal dose: 1000 mg/kgBrain and Coverings: Changes in circulation

Behavioral: General anesthetic

Vascular: Other changes
TPKVAL 8,126,1966
oral/rat lowest published lethal dose: 250 mg/kgBrain and Coverings: Changes in circulation

Behavioral: Muscle contraction or spasticity

Vascular: Other changes
TPKVAL 8,126,1966
oral/rat lethal dose (50 percent kill): 464 mg/kgNCILB* NCI-E-C-72-3252,1973
skin/rabbit lethal dose (50 percent kill): >5 gm/kgOlfaction: Other olfaction effects

Eye: Other eye effects

Behavioral: Food intake (animal)
ATDAEI 1,63,1990

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 13500 mg/kg/90D- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
VHTODE 28,219,1986
oral/rat lowest published toxic dose: 1500 mg/kg/10D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOXID9 12,103,1992
oral/rat lowest published toxic dose: 1000 mg/kg/10D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainTOXID9 12,103,1992
oral/rat lowest published toxic dose: 1500 mg/kg/10D- intermittentBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOXID9 12,103,1992

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWCMSHAF 53,809,2003
TOXICOLOGY REVIEWTXAPA9 243,239,2010
TOXICOLOGY REVIEWTXAPA9 243,239,2010
TOXICOLOGY REVIEWMUREAV 711,158,2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83649; Number of Industries 4; Total Number of Facilities 63; Number of Occupations 11; Total Number of Employees Exposed 4356; Total Number of Female Employees Exposed 530
National Occupational Hazard Survey 1974Hazard Code 83649; Number of Industries 4; Total Number of Facilities 211; Number of Occupations 20; Total Number of Employees Exposed 7379

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,ratNCITR* NCI-TR-82,1978
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