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p - Phenylenediamine, N - isopropyl - N' - phenyl -

RTECS #: ST2650000

CAS #: 101-72-4


UPDATE: February 2008 MW: 226.35 MF: C15H18N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 4 - Isopropylaminodiphenylamine
  2. 4010 NA
  3. Cyzone
  4. Elastozone 34
  5. Flexzone 3C
  6. N - 2 - Propyl - N' - phenyl - p - phenylenediamine
  7. N - Fenyl - N' - isopropyl - p - fenylendiamin (Czech)
  1. N - Isopropyl - N' - fenyl - p - fenylendiamin (Czech)
  2. N - Isopropyl - N' - phenyl - p - phenylenediamine
  3. N - Phenyl - N' - isopropyl - p - phenylenediamine
  4. NCI - C56304
  5. Nonox ZA
  6. Santoflex 36


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 mg/24 hour moderate 85JCAE -,483,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lethal dose (50 percent kill): 1,122 mg/kg N/R KOKABN 26,438,1977
oral
mouse
lowest published lethal dose: 1,000 mg/kg N/R TPKVAL 8,126,1966
oral
mouse
lethal dose : 1,500 mg/kg Behavioral: General anesthetic

Vascular: Other changes

Gastrointestinal: Other changes
TPKVAL 8,126,1966
oral
mouse
lethal dose : 2,000 mg/kg Liver: Other changes

Nutritional and Gross Metabolic: Body temperature decrease
TPKVAL 8,126,1966
oral
mouse
lethal dose (16 percent kill): 1,175 mg/kg N/R TPKVAL 8,126,1966
oral
mouse
lethal dose : 2,818 mg/kg N/R TPKVAL 8,126,1966
oral
rat
lethal dose (50 percent kill): 720 mg/kg N/R IPSTB3 3,93,1976
oral
rat
lowest published toxic dose: 2,716.2 mg/kg Behavioral: Sleep

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
TPKVAL 14,118,1975
oral
rat
lethal dose : 750 mg/kg N/R TPKVAL 8,126,1966
oral
rat
lethal dose : 1,000 mg/kg Behavioral: General anesthetic

Vascular: Other changes

Gastrointestinal: Other changes
TPKVAL 8,126,1966
oral
rat
lethal dose : 2,000 mg/kg Liver: Other changes

Nutritional and Gross Metabolic: Body temperature decrease
TPKVAL 8,126,1966
oral
rabbit
lethal dose : >7,500 mg/kg N/R IPSTB3 3,93,1976


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
MUREAV 539,77,2003
TOXICOLOGY REVIEW
ENTOX* -,104,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 2 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80314;
Number of Industries 5;
Total Number of Facilities 153;
Number of Occupations 11;
Total Number of Employees Exposed 1,686
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80314;
Number of Industries 3;
Total Number of Facilities 31;
Number of Occupations 9;
Total Number of Employees Exposed 4,130;
Total Number of Female Employees Exposed 478


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the manufacture of plastics, resins, rubber and synthetic textiles
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8854;8EHQ-0892-8907
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9281
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
IPSTB3 International Polymer Science and Technology. (Rapra Technology Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK)
KOKABN Kobunshi Kako. Polymer Applications. (Kobunshi Kankokai, Chiekoin Maruta-machi Kundaru, Kamigyo-ku, Kyoto 602, Japan) V.13- 1964-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-

Used in the manufacture of plastics, resins, rubber and synthetic textiles

RTECS Compound Description:
   Primary Irritant

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