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Registry of Toxic Effects of Chemical Substances (RTECS)

p-Phenylenediamine, N-isopropyl-N'-phenyl-

RTECS #

ST2650000

CAS #

101-72-4

Updated

July 2013

Molecular Weight

226.35

Molecular Formula

C15H18N2

Synonyms

4010 NA
4-Isopropylaminodiphenylamine
Cyzone
Elastozone 34
Flexzone 3C
N-2-Propyl-N'-phenyl-p-phenylenediamine
NCI-C56304
N-Fenyl-N'-isopropyl-p-fenylendiamin (Czech)
N-Isopropyl-N'-fenyl-p-fenylendiamin (Czech)
N-Isopropyl-N'-phenyl-p-phenylenediamine
Nonox ZA
N-Phenyl-N'-isopropyl-p-phenylenediamine
Santoflex 36

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg/24H moderate85JCAE -,483,1986

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 1250 mg/kg (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
HPV387 -,-,2001

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, melanoma Inhibitor Concentration (50 percent kill): 1.1 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.FCTOD7 50,2084,2012
oral/mouse lowest published lethal dose: 1500 mg/kgBehavioral: General anesthetic

Vascular: Other changes

Gastrointestinal: Other changes
TPKVAL 8,126,1966
oral/mouse lowest published lethal dose: 2000 mg/kgLiver: Other changes

Nutritional and Gross Metabolic: Body temperature decrease
TPKVAL 8,126,1966
oral/mouse lowest published lethal dose: 1000 mg/kgTPKVAL 8,126,1966
oral/mouse lethal dose (16 percent kill): 1175 mg/kgTPKVAL 8,126,1966
oral/mouse lethal dose (50 percent kill): 1122 mg/kgKOKABN 26,438,1977
oral/rabbit Lethal dose: >7500 mg/kgIPSTB3 3,93,1976
oral/rat lowest published toxic dose: 2716.2 mg/kgBehavioral: Sleep

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
TPKVAL 14,118,1975
oral/rat lethal dose (50 percent kill): 720 mg/kgIPSTB3 3,93,1976
oral/rat lowest published lethal dose: 2000 mg/kgLiver: Other changes

Nutritional and Gross Metabolic: Body temperature decrease
TPKVAL 8,126,1966
oral/rat lethal dose (50 percent kill): 900 mg/kgLung, Thorax, or Respiration: Other changes

Gastrointestinal: Gastritis

Liver: Other changes
HPV387 -,-,2001
oral/rat lowest published lethal dose: 750 mg/kgTPKVAL 8,126,1966
oral/rat lowest published lethal dose: 1000 mg/kgBehavioral: General anesthetic

Vascular: Other changes

Gastrointestinal: Other changes
TPKVAL 8,126,1966
skin/rabbit lethal dose (50 percent kill): >7940 mg/kgHPV387 -,-,2001

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 1500 mg/kg/30D- intermittentLiver: Changes in liver weight

Endocrine: Changes in spleen weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV387 -,-,2001
oral/rat lowest published toxic dose: 1620 mg/kg/90D- intermittentBrain and Coverings: Changes in brain weight

Liver: Changes in liver weight

Blood: Other changes
HPV387 -,-,2001

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 539,77,2003
TOXICOLOGY REVIEWENTOX* -,104,2005
TOXICOLOGY REVIEWMUREAV 741,32,2012

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 2 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 80314; Number of Industries 3; Total Number of Facilities 31; Number of Occupations 9; Total Number of Employees Exposed 4130; Total Number of Female Employees Exposed 478
National Occupational Hazard Survey 1974Hazard Code 80314; Number of Industries 5; Total Number of Facilities 153; Number of Occupations 11; Total Number of Employees Exposed 1686

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8854;8EHQ-0892-8907
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9281
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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