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Registry of Toxic Effects of Chemical Substances (RTECS)

p-Phenylenediamine, N,N'-diphenyl-

RTECS #

ST2275000

CAS #

74-31-7; 66746-42-7; 72711-53-6

Updated

October 2010

Molecular Weight

260.36

Molecular Formula

C18H16N2

Synonyms

1,4-Bis(phenylamino)benzene
4-Phenylaminodiphenylamine
AgeRite DPPD
Altofane DIP
Antage DP
Antigene P
Antioxidant H
Diafen FF
Diphenyl-p-phenylenediamine
DPPD
Ekaland DPPD
Flexamine G
JZF
N,N'-Difenyl-p-fenylendiamin (Czech)
N,N'-Diphenyl-p-phenylenediamine
Naugard J
Nocrac DP
Nonflex H
Nonox DPPD
Permanax 18
Permanax DPPD
p-Phenylaminodiphenylamine
Stabilizer DPPD
USAF GY-2

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg/24H mild85JCAE -,485,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislung/hamster1800 µg/LMUREAV 241,175,1990
mutation in mammalian somatic cellslung/hamster30 mg/LSWEHDO 9(Suppl 2),27,1983
mutation in microorganisms/Salmonella typhimurium10 µg/plate (-enzymatic activation step)PCBRD2 141,407,1984

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 450 mg/kg (14D prior to copulation/1-22D pregnant)Reproductive: Maternal effects: Parturition

Reproductive: Effects on newborn: Stillbirth
JAFCAU 4,796,1956
oral/rat 2500 mg/kg (1-22D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)AJANA2 110,29,1962
oral/mouse 4176 mg/kg (6-14D pregnant)Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)NTIS** PB223-160

Tumorigenic Data and References

Route/OrganismDoseEffectReference
subcutaneous/mouse lowest published toxic dose: 1000 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Tumors
NTIS** PB223-159

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 300 mg/kgNTIS** AD277-689
oral/mouse lethal dose (50 percent kill): 18 gm/kgGTPZAB 10(3),49,1966
oral/rat lethal dose (50 percent kill): 2370 mg/kg85JCAE -,485,1986

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 90 mg/kg/3D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
ARTODN 82,5,2008
oral/rat lowest published toxic dose: 182 gm/kg/2Y- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
JTSCDR 7,278,1982
oral/rat lowest published toxic dose: 20443 mg/kg/3W- continuousBlood: Change in clotting factorsTXAPA9 46,935,1982

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 584,1,2005

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 80282; Number of Industries 4; Total Number of Facilities 139; Number of Occupations 6; Total Number of Employees Exposed 7680
National Occupational Hazard Survey 1974Hazard Code 80282; Number of Industries 5; Total Number of Facilities 315; Number of Occupations 22; Total Number of Employees Exposed 7496

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8803
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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