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Registry of Toxic Effects of Chemical Substances (RTECS)

o-Phenylenediamine

RTECS #

SS7875000

CAS #

95-54-5

Updated

September 201

Molecular Weight

108.16

Molecular Formula

C6H8N2

Synonyms

1,2-Benzenediamine (9CI)
1,2-Fenylendiamin (Czech)
1,2-Phenylenediamine
2-Aminoaniline
C.I. 76010
C.I. Oxidation Base 16
EK 1700
IK 3
NSC 5354
o-Benzenediamine
o-Diaminobenzene
o-Fenylendiamin (Czech)
o-Phenylenediamine (ACGIH)
Orthamine
SQ 15500

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 0.5 mL severeHPV387 -,-,2001

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human10 mmol/LMUREAV 421,83,1998
Cytogenetic Analysisovary/hamster187 mg/LEMMUEG 27,67,1996
Cytogenetic Analysislung/hamster1 mg/LATSUDG 4,41,1980
DNA Damagemammary gland/human0.97 mg/L/24H (-enzymatic activation step)MUREAV 588,47,2005
DNA Damagelymphocyte/human15 mmol/LMUREAV 421,83,1998
DNA inhibitionHeLa cell/human7 mmol/LCRNGDP 13,2389,1992
DNA inhibitionoral/mouse200 mg/kgMUREAV 46,305,1977
micronucleus testintraperitoneal/hamster432 mg/kg/24HARTODN 43,249,1980
micronucleus testintraperitoneal/mouse216 mg/kg/24HARTODN 43,249,1980
micronucleus testoral/mouse216 mg/kg/24HARTODN 43,249,1980
micronucleus testintraperitoneal/guinea pig216 mg/kg/24HARTODN 43,249,1980
mutation in microorganisms/Salmonella typhimurium1 gm/L (+enzymatic activation step)JIMMBG 36,55,1980
mutation in microorganisms/Salmonella typhimurium1 µmol/plate (-enzymatic activation step)JTSCDR 7,61,1982
other mutation test systems/Salmonella typhimurium140 mg/LMUREAV 192,239,1987
phage inhibition capacity/Escherichia coli125 µg/wellMUREAV 260,349,1991
sister chromatid exchangelymphocyte/human10 mmol/LMUREAV 421,83,1998
Unscheduled DNA Synthesisliver/rat100 µmol/LENMUDM 5,803,1983

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): >91 mg/m3/4H85INA8 6,1214,1991
inhalation/rat lethal concentration (50 percent kill): 1873 mg/m3Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Olfaction: Other olfaction effects

Behavioral: Convulsions or effect on seizure threshold
GISAAA 51(1),73,1986
intraperitoneal/mouse lethal dose (50 percent kill): 245 mg/kgNCISP* JAN1986
intraperitoneal/rat lethal dose (50 percent kill): 516 mg/kgJTEHD6 2,657,1977
oral/cat lowest published lethal dose: 250 mg/kg85INA8 6,1214,1991
oral/guinea pig lethal dose (50 percent kill): 360 mg/kgGISAAA 53(7),62,1988
oral/mouse lethal dose (50 percent kill): 366 mg/kgGISAAA 53(7),62,1988
oral/rat lethal dose (50 percent kill): 510 mg/kgAutonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness
GTPZAB 32(9),50,1988
oral/wild bird lethal dose (50 percent kill): 133 mg/kgAECTCV 12,355,1983
skin/rabbit lowest published lethal dose: 1500 mg/kgBehavioral: Ataxia

Gastrointestinal: Changes in structure or function of salivary glands

Kidney, Ureter, and Bladder: Hematuria
NTIS** OTS0571626
skin/rat lethal dose (50 percent kill): >5 gm/kg85INA8 6,1214,1991
subcutaneous/mouse lethal dose (50 percent kill): 450 mg/kgKJMSAH 13,175,1962
unreported route/guinea pig lethal dose (50 percent kill): 360 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Olfaction: Other olfaction effects

Behavioral: Convulsions or effect on seizure threshold
GISAAA 51(1),73,1986
unreported route/mouse lethal dose (50 percent kill): 336 mg/kgGISAAA 50(6),78,1985
unreported route/rat lethal dose (50 percent kill): 660 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Olfaction: Other olfaction effects

Behavioral: Convulsions or effect on seizure threshold
GISAAA 51(1),73,1986

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 80 mg/m3/4H/10D- continuousLung, Thorax, or Respiration: Dyspnea

Skin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0571513
skin/rabbit lowest published toxic dose: 3 gm/kg/2W- intermittentBlood: Normocytic anemia

Skin: After systemic exposure: Dermatitis, other

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0555823

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 mg/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 mg/m3, Carcinogen, JUL2008
Occupational Exposure Limit-AUSTRIATRK-TMW 0.1 mg/m3;KZW 0.4 mg/m3, skin, sen, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 mg/m3, carc, MAY2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 mg/m3, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.1 mg/m3, s3 sen, MAY2012
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 mg/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0,1 mg/m3, JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.5 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg/m3, carc 3, inhal, sen, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X4334; Number of Industries 2; Total Number of Facilities 342; Number of Occupations 4; Total Number of Employees Exposed 3076; Total Number of Female Employees Exposed 1372

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal; N crassa-aneuploidy
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #87
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