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Registry of Toxic Effects of Chemical Substances (RTECS)

m-Phenylenediamine

RTECS #

SS7700000

CAS #

108-45-2

Updated

September 201

Molecular Weight

108.16

Molecular Formula

C6H8N2

Synonyms

1,3-Benzenediamine (9CI)
1,3-Diaminobenzene
1,3-Phenylenediamine
3-Aminoaniline
APCO 2330
C.I. 76025
Developer 11
Developer C
Developer H
Developer M
Direct Brown BR
Direct Brown GG
m-Aminoaline
m-Benzenediamine
m-Diaminobenzene
Metaphenylenediamine
m-Fenylendiamin (Czech)
m-Phenylenediamine (ACGIH)
Phenylenediamine

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 µL severeNTIS** OTS0559504

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
body fluid assaySalmonella typhimurium/rat240 mg/kgMUREAV 138,137,1984
Cytogenetic Analysislung/hamster12 mg/LGMCRDC 27,95,1981
DNA inhibitionoral/mouse200 mg/kgMUREAV 46,305,1977
micronucleus testintraperitoneal/mouse400 mg/kg/24H-continuousCYTOAN 57,149,1992
micronucleus testovary/hamster231 µmol/L/24H (-enzymatic activation step)MUREAV 751,1,2013
morphological transformembryo/hamster50 µg/LNCIMAV 58,243,1981
mutation in mammalian somatic cellslymphocyte/mouse50 mg/LJEPTDQ 1(1),87,1977
mutation in microorganisms/Salmonella typhimurium1 nmol/plate/20MEMMUEG 38,268,2001
mutation in microorganisms/Salmonella typhimurium3.3 mmol/L/20MEMMUEG 38,80,2001
mutation in microorganisms/Salmonella typhimurium250 µg/plate (+enzymatic activation step)JACTDZ 2(4),325,1983
mutation in microorganisms/Salmonella typhimurium10 µg/plate (-enzymatic activation step)BCPCA6 26,729,1977
phage inhibition capacity/Escherichia coli175 µg/wellMUREAV 260,349,1991

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 375 mg/kg (30D male)Reproductive: Effects on embryo or fetus: Fetal deathSheCW# 25MAR1977
oral/rat 900 mg/kg (6-15D pregnant)Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
NTIS** OTS0555025

Tumorigenic Data and References

Route/OrganismDoseEffectReference
subcutaneous/rat lowest published toxic dose: 1485 mg/kg/47W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
KJMSAH 13,175,1962

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published lethal dose: 400 mg/kgRBPMAZ 22,1,1952
intraperitoneal/rat lethal dose (50 percent kill): 283 mg/kgJTEHD6 2,657,1977
intravenous/Dog lowest published lethal dose: 17 mg/kgJIDHAN 4,386,1923
oral/cat lowest published lethal dose: 300 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis
JIDHAN 4,386,1923
oral/guinea pig lethal dose (50 percent kill): 450 mg/kgGISAAA 53(7),62,1988
oral/mouse lethal dose (50 percent kill): 67700 µg/kgGISAAA 53(7),62,1988
oral/rabbit lethal dose (50 percent kill): 437 mg/kgGISAAA 53(7),62,1988
oral/rat lethal dose (50 percent kill): 280 mg/kgGISAAA 53(7),62,1988
oral/wild bird lethal dose (50 percent kill): 562 mg/kgAECTCV 12,355,1983
skin/rabbit lowest published lethal dose: 1500 mg/kgLung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Other changes in urine composition
NTIS** OTS0555804
subcutaneous/Dog lowest published lethal dose: 100 mg/kgNTIS** OTS0555804
subcutaneous/mouse lethal dose (50 percent kill): 90 mg/kgKJMSAH 13,175,1962
subcutaneous/rabbit lowest published lethal dose: 200 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis
JIDHAN 4,386,1923
subcutaneous/rat lowest published lethal dose: 80 mg/kgNTIS** OTS0555804
unreported route/guinea pig lethal dose (50 percent kill): 450 mg/kgGTPZAB 31(8),46,1987
unreported route/mouse lethal dose (50 percent kill): 65300 µg/kgGTPZAB 31(8),46,1987
unreported route/rabbit lethal dose (50 percent kill): 438 mg/kgGTPZAB 31(8),46,1987
unreported route/rat lethal dose (50 percent kill): 351 mg/kgGTPZAB 31(8),46,1987

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 900 mg/kg/2W- intermittentBehavioral: Somnolence (general depressed activity)

Kidney, Ureter, and Bladder: Other changes
NTIS** OTS0555804

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 mg/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 16,111,1978
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 16,111,1978
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
TOXICOLOGY REVIEWMUTAEX 23,271,2008
TOXICOLOGY REVIEWTXAPA9 243,239,2010
TOXICOLOGY REVIEWTXAPA9 243,239,2010
TOXICOLOGY REVIEWFCTOD7 49,1877,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 mg/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 mg/m3, MAY2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 mg/m3, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.1 mg/m3, s3 sen, MAY2012
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 mg/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0,1 mg/m3, JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.1 mg/m3, JUN2003
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.1 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83124; Number of Industries 12; Total Number of Facilities 3739; Number of Occupations 18; Total Number of Employees Exposed 40632; Total Number of Female Employees Exposed 32320
National Occupational Hazard Survey 1974Hazard Code 83124; Number of Industries 18; Total Number of Facilities 1364; Number of Occupations 21; Total Number of Employees Exposed 12590

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Rodent dominant lethal
EPA GENETOX PROGRAM 1988, Positive: SHE-clonal assay; Histidine reversion-Ames test
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
OSHA ANALYTICAL METHOD #87
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