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Phenol, 2,4,6 - trichloro -

RTECS #: SN1575000

CAS #: 88-06-2


UPDATE: August 2008 MW: 197.44 MF: C6H3Cl3O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 2,4,6 - Trichlorfenol (Czech)
  2. 2,4,6 - Trichlorophenol
  3. Dowcide 2S
  4. Dowicide 2S
  1. NCI - C02904
  2. OMAL
  3. Phenachlor
  4. RCRA waste number U231


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
250 µg/24 hour severe 85JCAE -,525,1986
skin
rabbit
20 mg/24 hour moderate 85JCAE -,525,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 400 mg/L MUREAV 303,101,1993
cytogenetic analysis hamster lung 500 mg/L MUREAV 303,101,1993
DNA damage human Ascites tumor 50 mg/L/2 hour FCTOD7 42,1323,2004
DNA damage other microorganisms 500 µmol/L CBINA8 69,333,1989
mutation in microorganisms Salmonella typhimurium 10 µg/plate (-enzymatic activation step) TECSDY 14,143,1987
mutation in microorganisms Saccharomyes cerevisiae 400 mg/L (-enzymatic activation step) EVSRBT 12,325,1978
micronucleus test hamster lung 30 mg/L MUREAV 280,175,1992
mutation in mammalian somatic cells hamster lung 20 mg/L CMSHAF 14,1617,1985
mutation in mammalian somatic cells mouse lymphocyte 80 mg/L EMMUEG 12,85,1988
other mutation test systems hamster lung 100 mg/L MUREAV 303,101,1993
sex chromosome loss and nondisjunction hamster lung 30 mg/L MUREAV 280,175,1992
specific locus test intraperitoneal
mouse
50 mg/kg EVSRBT 12,325,1978
specific locus test mouse liver 608 µmol/L MUREAV 608,29,2006


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 12,500 mg/kg (2 week prior to copulation/1-21 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) FAATDF 6,233,1986


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 441 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NCITR* NCI-TR-155,1979
oral
mouse
toxic dose : 882 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NCITR* NCI-TR-155,1979
oral
rat
lowest published toxic dose: 185 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia

Blood: Lymphoma including Hodgkin's disease
NCITR* NCI-TR-155,1979
oral
rat
toxic dose : 374 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia

Blood: Lymphoma including Hodgkin's disease
NCITR* NCI-TR-155,1979


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 276 mg/kg N/R VCVGK* -,245,1994
intraperitoneal
rat
lethal dose (50 percent kill): 276 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Nutritional and Gross Metabolic: Body temperature increase
BJPCAL 13,20,1958
oral
guinea pig
lethal dose (50 percent kill): 1 gm/kg N/R FMCHA2 -,C310,1991
oral
mammal (species unspecified)
lethal dose (50 percent kill): 454 mg/kg N/R GISAAA 45(10),16,1980
oral
mouse
lethal dose (50 percent kill): 770 mg/kg N/R VCVGK* -,245,1994
oral
rat
lethal dose (50 percent kill): 820 mg/kg N/R VCVGK* -,245,1994
skin
mammal (species unspecified)
lethal dose (50 percent kill): 700 mg/kg N/R GISAAA 45(10),16,1980


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 3 mg/m3/3 year- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Other changes
VCVGK* -,247,1994
oral
rat
lowest published toxic dose: 21,600 mg/kg/90 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
JACTDZ 9(5),497,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Human Limited Evidence IMEMDT 41,319,1986
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMSUDL 7,154,1987
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 71,769,1999
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 20,349,1979
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
ADMOL* 1,85,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - DENMARK time-weighted average 0.5 mg/m3, OCT 2002
Occupational Exposure Limit - RUSSIA short term exposure limit 0.3 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.5 mg/m3;
short term exposure limit 1.5 mg/m3, Skin, Carcinogen, JUN2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84393;
Number of Industries 1;
Total Number of Facilities 14;
Number of Occupations 2;
Total Number of Employees Exposed 112
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84393;
Number of Industries 1;
Total Number of Facilities 17;
Number of Occupations 1;
Total Number of Employees Exposed 851;
Total Number of Female Employees Exposed 187


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/91/181545/AS)
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; S cerevisiae-forward mutation
EPA GENETOX PROGRAM 1988, Negative: Mouse spot test; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion; S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in manufacturing slime-control agents and as effective germicide and preservative
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);clear evidence:mouse,rat NCITR* NCI-TR-155,1979
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ADMOL*
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM.
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
EVSRBT Environmental Science Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach Science Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used in manufacturing slime-control agents and as effective germicide and preservative

NOISH PROFILE (CHLOROPHENOLS), SRC, 3/81

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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