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Registry of Toxic Effects of Chemical Substances (RTECS)

Phenol, 2,4,6-trichloro-

RTECS #

SN1575000

CAS #

88-06-2

Updated

December 2012

Molecular Weight

197.44

Molecular Formula

C6H3Cl3O

Synonyms

2,4,6-Trichlorfenol (Czech)
2,4,6-Trichlorophenol
Dowcide 2S
Dowicide 2S
NCI-C02904
OMAL
Phenachlor
RCRA waste number U231

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 250 µg/24H severe85JCAE -,525,1986
skin /rabbit 20 mg/24H moderate85JCAE -,525,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster400 mg/LMUREAV 303,101,1993
Cytogenetic Analysislung/hamster500 mg/LMUREAV 303,101,1993
DNA Damage/Other microorganisms500 µmol/LCBINA8 69,333,1989
DNA DamageAscites tumor/human50 mg/L/2HFCTOD7 42,1323,2004
micronucleus testlung/hamster30 mg/LMUREAV 280,175,1992
mutation in mammalian somatic cellslymphocyte/mouse80 mg/LEMMUEG 12,85,1988
mutation in mammalian somatic cellslung/hamster20 mg/LCMSHAF 14,1617,1985
mutation in microorganisms/Salmonella typhimurium10 µg/plate (-enzymatic activation step)TECSDY 14,143,1987
mutation in microorganisms/Saccharomyes cerevisiae400 mg/L (-enzymatic activation step)EVSRBT 12,325,1978
other mutation test systemslung/hamster100 mg/LMUREAV 303,101,1993
sex chromosome loss and nondisjunctionlung/hamster30 mg/LMUREAV 280,175,1992
specific locus testintraperitoneal/mouse50 mg/kgEVSRBT 12,325,1978
specific locus testliver/mouse608 µmol/LMUREAV 608,29,2006

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 12500 mg/kg (2W prior to copulation/1-21D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)FAATDF 6,233,1986

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 441 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NCITR* NCI-TR-155,1979
oral/mouse toxic dose: 882 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NCITR* NCI-TR-155,1979
oral/rat toxic dose: 374 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia

Blood: Lymphoma including Hodgkin's disease
NCITR* NCI-TR-155,1979
oral/rat lowest published toxic dose: 185 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia

Blood: Lymphoma including Hodgkin's disease
NCITR* NCI-TR-155,1979

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, endocrine tumor Inhibitor Concentration Low: 1.1 µmol/L/48HIn Vitro Toxicity Studies: Other assays

Biochemical: Metabolism (intermediary): Effect on cyclic nucleotides
TXCYAC 282,146,2011
In Vitro/Human, endocrine tumor Inhibitor Concentration Low: 0.4 µmol/L/48HEndocrine: Other changesTXCYAC 282,146,2011
In Vitro/Human, endocrine tumor Inhibitor Concentration Low: 3.4 µmol/L/24HEndocrine: Other changes

In Vitro Toxicity Studies: Other assays

Biochemical: Metabolism (intermediary): Effect on cyclic nucleotides
TXCYAC 282,146,2011
intraperitoneal/mouse lethal dose (50 percent kill): 276 mg/kgVCVGK* -,245,1994
intraperitoneal/rat lethal dose (50 percent kill): 276 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Nutritional and Gross Metabolic: Body temperature increase
BJPCAL 13,20,1958
oral/guinea pig lethal dose (50 percent kill): 1 gm/kgFMCHA2 -,C310,1991
oral/mammal (species unspecified) lethal dose (50 percent kill): 454 mg/kgGISAAA 45(10),16,1980
oral/mouse lethal dose (50 percent kill): 770 mg/kgVCVGK* -,245,1994
oral/rat lethal dose (50 percent kill): 820 mg/kgVCVGK* -,245,1994
skin/mammal (species unspecified) lethal dose (50 percent kill): 700 mg/kgGISAAA 45(10),16,1980

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 3 mg/m3/3Y- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Other changes
VCVGK* -,247,1994
oral/rat lowest published toxic dose: 21600 mg/kg/90D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
JACTDZ 9(5),497,1990

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Human Limited EvidenceIMEMDT 41,319,1986
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMSUDL 7,154,1987
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 71,769,1999
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 20,349,1979
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWADMOL* 1,85,2006
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 mg/m3, skin, carc, MAY2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.5 mg/m3, carc, skin, NOV2011
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.3 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.5 mg/m3;short term exposure limit 1.5 mg/m3, Skin, Carcinogen, JUN2005

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84393; Number of Industries 1; Total Number of Facilities 17; Number of Occupations 1; Total Number of Employees Exposed 851; Total Number of Female Employees Exposed 187
National Occupational Hazard Survey 1974Hazard Code 84393; Number of Industries 1; Total Number of Facilities 14; Number of Occupations 2; Total Number of Employees Exposed 112

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/91/181545/AS)
EPA GENETOX PROGRAM 1988, Negative: Mouse spot test; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; S cerevisiae-forward mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);clear evidence:mouse,ratNCITR* NCI-TR-155,1979
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
On EPA IRIS database
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