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Registry of Toxic Effects of Chemical Substances (RTECS)

Phenol, 2,4,5-trichloro-

RTECS #

SN1400000

CAS #

95-95-4

Updated

December 2012

Molecular Weight

197.44

Molecular Formula

C6H3Cl3O

Synonyms

2,4,5-Trichlorophenol
Collunosol
Dowicide 2
NCI-C61187
Preventol I
RCRA waste number U230
TCP

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster150 mg/LMUREAV 303,101,1993
mutation in microorganisms/Salmonella typhimurium10 µg/plate (+/-enzymatic activation step)TECSDY 14,143,1987

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 4 gm/kg (8-12D pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)JTEHD6 10,541,1982

Tumorigenic Data and References

Route/OrganismDoseEffectReference
skin/mouse lowest published toxic dose: 6700 mg/kg/16W- intermittentTumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors
CNREA8 19,413,1959

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lethal dose (50 percent kill): 355 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Nutritional and Gross Metabolic: Body temperature increase
BJPCAL 13,20,1958
intraperitoneal/rat lethal dose (50 percent kill): 355 mg/kgVCVGK* -,245,1994
intravenous/mouse lethal dose (50 percent kill): 56 mg/kgCSLNX* NX#03492
oral/guinea pig lethal dose (50 percent kill): 1000 mg/kgVCVGK* -,245,1994
oral/mouse lethal dose (50 percent kill): 600 mg/kgPHARAT 30,147,1975
oral/rat lethal dose (50 percent kill): 820 mg/kgVCVGK* -,245,1994
subcutaneous/rat lethal dose (50 percent kill): 2260 mg/kgVCVGK* -,245,1994
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 150 mg/kg30ZDA9 -,102,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 3 mg/m3/3Y- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Other changes
VCVGK* -,247,1994
oral/mammal (species unspecified) lowest published toxic dose: 106.5 mg/kg/213D- intermittentLiver: Changes in liver weight

Endocrine: Changes in spleen weight
VCVGK* -,247,1994
oral/mouse lowest published toxic dose: 6048 mg/kg/12W- continuousLiver: Other changes

Liver: Changes in liver weight
CMSHAF 1,153,1972
oral/rat lowest published toxic dose: 98 gm/kg/98D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainTXAPA9 3,63,1961

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Human Limited EvidenceIMEMDT 41,319,1986
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 20,349,1979
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 71,769,1999

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,215,1998
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 mg/m3, skin, MAY2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.5 mg/m3, skin, NOV2011
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-SWEDENtime-weighted average 0.5 mg/m3;short term exposure limit 1.5 mg/m3, Skin, Carcinogen, JUN2005

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M1866; Number of Industries 11; Total Number of Facilities 184; Number of Occupations 9; Total Number of Employees Exposed 895; Total Number of Female Employees Exposed 27
National Occupational Hazard Survey 1974Hazard Code M1866; Number of Industries 9; Total Number of Facilities 193; Number of Occupations 9; Total Number of Employees Exposed 1272

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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