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Phenol, 2,3,6 - trichloro -

RTECS #: SN1300000

CAS #: 933-75-5


UPDATE: May 2008 MW: 197.44 MF: C6H3Cl3O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 2,3,6 - Trichlorophenol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster lung 200 mg/L MUREAV 241,175,1990
cytogenetic analysis hamster ovary 400 mg/L MUREAV 303,101,1993
mutation in microorganisms Salmonella typhimurium 10 g/plate (-enzymatic activation step) TECSDY 14,143,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lethal dose (50 percent kill): 308 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Nutritional and Gross Metabolic: Body temperature increase
BJPCAL 13,20,1958
intraperitoneal
rat
lethal dose (50 percent kill): 308 mg/kg N/R VCVGK* -,245,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 3 mg/m3/3 year- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Other changes
VCVGK* -,247,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - DENMARK time-weighted average 0.5 mg/m3, OCT 2002
Occupational Exposure Limit - SWEDEN time-weighted average 0.5 mg/m3;
short term exposure limit 1.5 mg/m3, Skin, Carcinogen, JUN2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE

BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach Science Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as intermediate in production of fungicides and plant growth regulators

NOISH PROFILE (CHLOROPHENOLS), SRC, 3/81

RTECS Compound Description:
   Mutagen
   Human Data

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