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Registry of Toxic Effects of Chemical Substances (RTECS)

Phenol, 2,2'-methylenebis(3,4,6-trichloro-

RTECS #

SM0700000

CAS #

70-30-4; 8054-98-6; 139411-96-4

Updated

July 2011

Molecular Weight

406.89

Molecular Formula

C13H6Cl6O2

Synonyms

2,2',3,3',5,5'-Hexachloro-6,6'-dihydroxydiphenylmethane
2,2'-Dihydroxy-3,3',5,5',6,6'-hexachlorodiphenylmethane
2,2'-Dihydroxy-3,5,6,3',5',6'-hexachlorodiphenylmethane
2,2'-Methylenebis(3,4,6-trichlorophenol)
3,3',4,4',6,6'-Hexachloro-2,2'-methylendiphenol
Acigena
Almederm
AT 7
B32
Bis(2-hydroxy-3,5,6-trichlorophenyl)methane
Bis(3,5,6-Trichloro-2-hydroxyphenyl)methane
Compound G-11
Cotofilm
Dermadex
Distodin
Exofene
Fesia-sin
Fostril
G 11 (bactericide)
G-11
Gamophen
Gamophene
German-Medica
Hexabalm
Hexachlorofen (Czech)
Hexachlorophen
Hexachlorophene
Hexafen
Hexophene
Hexosan
Nabac
Nabac 25 EC
NCI-C02653
Neosept V
pHisoHex
RCRA waste number U132
Ritosept
Septisol
Septofen
Steral
Steraskin
Surgi-Cen
Surofene
Tersaseptic

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /Dog 3 mg/24HAAOPAF 53,817,1955
eye /rabbit 1500 mg/24HAAOPAF 53,817,1955
skin /guinea pig 30 µg open irritation test mildJSCCA5 25,113,1974
skin /guinea pig 1250 µg/24H mildJSCCA5 25,113,1974
skin /human 3 mg/3D- intermittent mild85DKA8 -,127,1977
skin /human 50 µg/24H mildJSCCA5 25,113,1974
skin /rabbit 30 µg open irritation test mildJSCCA5 25,113,1974
skin /rabbit 1250 µg/24H mildJSCCA5 25,113,1974

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 33500 µg/m3/24H (1-20D pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)GISAAA 49(8),25,1984
intravaginal/rat 80 mg/kg (8-11D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Urogenital system
AEHLAU 28,43,1974
intravaginal/rat 300 mg/kg (8-11D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
AEHLAU 28,43,1974
oral/rat 435 mg/kg (15-22D preg/21D after birth)Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
FCTXAV 14,421,1976
oral/rat 137 mg/kg (14W male/14W pre-3W after birth)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)JAFCAU 23,866,1975
oral/rat 50 mg/kg (7-8D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)TJADAB 5,264,1972
oral/rat 315 mg/kg (63D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)TOLED5 5,405,1980
oral/Dog 189 mg/kg (63D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)TOLED5 5,405,1980
skin/mouse 31.5 mg/kg (1-21D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)VCVGK* -,256,1994
skin/rat 33 mg/kg (1-22D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)VCVGK* -,256,1994
skin/mouse 3 mg/kg (7-8D pregnant)Reproductive: Other developmental abnormalitiesVCVGK* -,256,1994
skin/rat 3 mg/kg (7-8D pregnant)Reproductive: Other developmental abnormalitiesVCVGK* -,256,1994
skin/mouse 10.5 mg/kg (15-21D pregnant)Reproductive: Other developmental abnormalitiesVCVGK* -,256,1994
skin/rat 10.5 mg/kg (15-21D pregnant)Reproductive: Other developmental abnormalitiesVCVGK* -,256,1994
skin/mouse 3150 µg/kg (1-21D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
GISAAA 47(10),26,1982
skin/mouse 31500 µg/kg (1-21D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Other developmental abnormalities
GISAAA 47(10),26,1982
subcutaneous/mouse 75 mg/kg (7-12D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
PPASAK 49,110,1975

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 33500 µg/m3/52WTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
VOONAW 33(1),62,1987
skin/mouse lowest published toxic dose: 8400 mg/kg/21W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
CNREA8 19,413,1959

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Chicken, neurons Inhibitor Concentration (50 percent kill): 75 µmol/L/21HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 7,653,1993
In Vitro/Chicken, neurons Inhibitor Concentration (10 percent kill): 20 µmol/L/21HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 7,653,1993
In Vitro/Chicken, neurons Inhibitor Concentration (50 percent kill): 1 µmol/L/20HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 7,653,1993
In Vitro/Chicken, neurons Inhibitor Concentration (10 percent kill): 0.4 µmol/L/20HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 7,653,1993
inhalation/mouse lethal concentration (50 percent kill): 290 mg/m3GISAAA 49(8),25,1984
inhalation/rat lethal concentration (50 percent kill): 340 mg/m3GISAAA 49(8),25,1984
intraperitoneal/Dog lowest published lethal dose: 25 mg/kgVCVGK* -,256,1994
intraperitoneal/guinea pig lowest published lethal dose: 25 mg/kgAIPTAK 163,210,1966
intraperitoneal/mouse lowest published lethal dose: 10 mg/kgVCVGK* -,255,1994
intraperitoneal/mouse lethal dose (50 percent kill): 20 mg/kgZMMPAO 234,110,1976
intraperitoneal/rat lethal dose (50 percent kill): 22 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Body temperature increase
TXAPA9 24,239,1973
intraperitoneal/rat lethal dose (50 percent kill): 22 mg/kgVCVGK* -,255,1994
intravenous/Dog lowest published lethal dose: 5 mg/kgVCVGK* -,256,1994
intravenous/Dog lowest published lethal dose: 5 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Blood: Change in clotting factors
SURGAZ 24,542,1948
intravenous/rabbit lethal dose (50 percent kill): 8.5 mg/kgVCVGK* -,256,1994
intravenous/rat lethal dose (50 percent kill): 7.5 mg/kgVCVGK* -,256,1994
intravenous/rat lethal dose (50 percent kill): 7500 µg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea
TXAPA9 25,332,1973
oral/child lowest published lethal dose: 250 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Other changes
MJAUAJ 1,737,1963
oral/Dog lowest published lethal dose: 40 mg/kgVCVGK* -,256,1994
oral/domestic animal lethal dose (50 percent kill): 30 mg/kgANYAA9 320,426,1979
oral/guinea pig lethal dose (50 percent kill): 60 mg/kgNIIRDN 6,742,1982
oral/guinea pig lowest published lethal dose: 50 mg/kgVCVGK* -,256,1994
oral/human lowest published lethal dose: 200 mg/kgBrain and Coverings: Other degenerative changes

Gastrointestinal: Nausea or vomiting

Nutritional and Gross Metabolic: Dehydration
VCVGK* -,256,1994
oral/infant lowest published toxic dose: 257 mg/kg/7D- intermittentGastrointestinal: Nausea or vomiting

Gastrointestinal: Hypermotility, diarrhea

Vascular: Shock
AJDCAI 111,333,1966
oral/mouse lethal dose (50 percent kill): 67 mg/kgLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Other changes
CMJOAP 82,691,1963
oral/mouse lethal dose (50 percent kill): 67 mg/kgVCVGK* -,255,1994
oral/rabbit lethal dose (50 percent kill): 40690 µg/kgTJADAB 20,413,1979
oral/rat lethal dose (50 percent kill): 56 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea
TXAPA9 25,332,1973
oral/rat lethal dose (50 percent kill): 50 mg/kgVCVGK* -,255,1994
oral/woman lowest published toxic dose: 600 mg/kgCardiac: Cardiomyopathy including infarction

Gastrointestinal: Nausea or vomiting
JAMAAP 181,587,1962
skin/guinea pig lethal dose (50 percent kill): 1100 mg/kgGISAAA 47(10),26,1982
skin/mouse lethal dose (50 percent kill): 270 mg/kgGISAAA 47(10),26,1982
skin/rat lethal dose (50 percent kill): 1840 mg/kgVCVGK* -,256,1994
skin/rat lowest published lethal dose: 600 mg/kgVCVGK* -,256,1994
subcutaneous/mouse lethal dose (50 percent kill): 46 mg/kgNEZAAQ 16,13,1961
subcutaneous/rat lethal dose (50 percent kill): 7650 µg/kgIMSUAI 38,64,1969

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 420 mg/kg/7D- intermittentBrain and Coverings: Other degenerative changes

Autonomic Nervous System: Other (direct) parasympathomimetic

Biochemical: Metabolism (intermediary): Amino acids (including renal excretion)
AECTCV 16,631,1987
oral/mouse lowest published toxic dose: 420 mg/kg/7D- intermittentBrain and Coverings: Increased intracranial pressure

Brain and Coverings: Demyelination

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,256,1994
oral/mouse lowest published toxic dose: 350 mg/kg/14D- intermittentBrain and Coverings: Increased intracranial pressure

Brain and Coverings: Demyelination

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,256,1994
oral/rat lowest published toxic dose: 150 mg/kg/5D- intermittentBrain and Coverings: Other degenerative changesNRTXDN 28,252,2007
oral/rat lowest published toxic dose: 2730 mg/kg/13W- continuousBrain and Coverings: Changes in brain weight

Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Muscle weakness
TXAPA9 27,591,1974
oral/rat lowest published toxic dose: 1669 mg/kg/16W- continuousBrain and Coverings: Other degenerative changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
TXAPA9 24,239,1973
oral/rat lowest published toxic dose: 2450 mg/kg/14W- continuousBrain and Coverings: Changes in brain weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AEHLAU 23,114,1971
oral/rat lowest published toxic dose: 360 mg/kg/9D- intermittentBrain and Coverings: Other degenerative changes

Brain and Coverings: Changes in brain weight

Eye: Optic nerve neuropathy
FAATDF 11,519,1988
oral/rat lowest published toxic dose: 1250 mg/kg/50D- intermittentBrain and Coverings: Changes in brain weight

Behavioral: Alteration of operant conditioning

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXCYAC 9,331,1978
skin/Dog lowest published toxic dose: 58800 mg/kg/12W- intermittentEye: Mydriasis (pupilliary dilation)

Eye: Other eye effects
TOLED5 5,77,1980
skin/guinea pig lowest published toxic dose: 1500 mg/kg/30D- intermittentLiver: Fatty liver degeneration

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Metabolism (intermediary): Lipids including transport
JTOTDO 13,317,1994
skin/rat lowest published toxic dose: 1440 mg/kg/30D- intermittentBrain and Coverings: Other degenerative changes

Skin: After systemic exposure: Dermatitis, other
TXAPA9 19,375,1971

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 20,241,1979
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 20,241,1979
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
TOXICOLOGY REVIEWJCPCBR 13,439,1973
TOXICOLOGY REVIEWAEHLAU 23,119,1971
TOXICOLOGY REVIEWJACHDX 1,263,1975
TOXICOLOGY REVIEWPLMJAP 5,100,1974
TOXICOLOGY REVIEWPRTODI 1,56,1973
TOXICOLOGY REVIEWMUREAV 488,151,2001
TOXICOLOGY REVIEWREPTED 22,196,2006
TOXICOLOGY REVIEWENTOX* -,520,2005
TOXICOLOGY REVIEWNBREV* 5,1,1981

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,185,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.1 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 36710; Number of Industries 11; Total Number of Facilities 3480; Number of Occupations 41; Total Number of Employees Exposed 403543; Total Number of Female Employees Exposed 351670
National Occupational Hazard Survey 1974Hazard Code 36710; Number of Industries 18; Total Number of Facilities 2049; Number of Occupations 33; Total Number of Employees Exposed 88875

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:ratNCITR* NCI-TR-40,1978
On EPA IRIS database
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