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Registry of Toxic Effects of Chemical Substances (RTECS)

Phenol, 2,3,5,6-tetrachloro-

RTECS #

SM9450000

CAS #

935-95-5

Updated

December 2012

Molecular Weight

231.88

Molecular Formula

C6H2Cl4O

Synonyms

2,3,5,6-Tetrachlorophenol

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislung/hamster60 mg/LMUREAV 241,175,1990

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 48 mg/kgVCVGK* -,245,1994
oral/gerbil lethal dose (50 percent kill): 979 mg/kgARTODN 40,63,1978
oral/mouse lethal dose (50 percent kill): 89 mg/kgVCVGK* -,245,1994
oral/rat lowest published toxic dose: 300 mg/kgGastrointestinal: Other changes

Liver: Change in gall bladder structure or function

Liver: Other changes
VCVGK* -,248,1994
skin/rat lethal dose (20 percent kill): 2 mg/kg/1HVCVGK* -,248,1994
skin/rat lethal dose (10 percent kill): 2 mg/kg/1HVCVGK* -,248,1994
skin/rat lowest published lethal dose: 2 gm/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness
BECTA6 31,680,1983

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 700 mg/kg/7D- intermittentLiver: Other changes

Gastrointestinal: Other changes

Liver: Change in gall bladder structure or function
VCVGK* -,248,1994

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-SWEDENtime-weighted average 0.5 mg/m3;short term exposure limit 1.5 mg/m3, Skin, JUN2005
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