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Registry of Toxic Effects of Chemical Substances (RTECS)

Phenol, 2,3,4,6-tetrachloro-

RTECS #

SM9275000

CAS #

58-90-2; 12698-64-5

Updated

December 2012

Molecular Weight

231.88

Molecular Formula

C6H2Cl4O

Synonyms

2,3,4,6-Tetrachlorophenol
2,4,5,6-Tetrachlorophenol
Dowicide 6
RCRA waste number U212

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislung/hamster250 mg/LMUREAV 241,175,1990
DNA Damagefibroblast/human0.25 mmol/L/1HTOLED5 147,35,2004
mutation in mammalian somatic cellslung/hamster3500 µg/LCMSHAF 14,1617,1985

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 300 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemTXAPA9 28,146,1974

Tumorigenic Data and References

Route/OrganismDoseEffectReference
subcutaneous/mouse lowest published toxic dose: 100 mg/kgTumorigenic: Carcinogenic by RTECS criteria

Blood: Tumors
NTIS** PB223-159

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 82 mg/kgVCVGK* -,245,1994
intraperitoneal/rat lethal dose (50 percent kill): 130 mg/kgVCVGK* -,245,1994
intraperitoneal/rat lethal dose (50 percent kill): 130 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature increase
BJPCAL 13,20,1958
oral/Dog lethal dose (50 percent kill): 250 mg/kgVCVGK* -,246,1994
oral/gerbil lethal dose (50 percent kill): 698 mg/kgARTODN 40,63,1978
oral/guinea pig lethal dose (50 percent kill): 250 mg/kgFMCHA2 -,C299,1991
oral/mouse lethal dose (50 percent kill): 30 mg/kgVCVGK* -,245,1994
oral/rat lowest published toxic dose: 300 mg/kgGastrointestinal: Other changes

Liver: Change in gall bladder structure or function

Liver: Other changes
VCVGK* -,248,1994
oral/rat lethal dose (50 percent kill): 140 mg/kgVCVGK* -,245,1994
skin/rabbit lethal dose (50 percent kill): 250 mg/kgVCVGK* -,245,1994
skin/rat lethal dose (20 percent kill): 2 mg/kg/1HVCVGK* -,248,1994
skin/rat lethal dose (10 percent kill): 2 mg/kg/1HVCVGK* -,248,1994
skin/rat lethal dose (50 percent kill): 485 mg/kgVCVGK* -,245,1994
skin/rat lethal dose (50 percent kill): 485 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness
BECTA6 31,680,1983
subcutaneous/rat lowest published lethal dose: 210 mg/kgHBTXAC 5,129,1959
Tank with water/Daphnia lethal concentration (50 percent kill): 290 µg/L/48HTIVIEQ 31,125,1995

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 700 mg/kg/7D- intermittentLiver: Other changes

Gastrointestinal: Other changes

Liver: Change in gall bladder structure or function
VCVGK* -,248,1994

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Human Limited EvidenceIMEMDT 41,319,1986

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.5 mg/m3;KZW 1.5 mg/m3, inhal, skin, 2007
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-SWEDENtime-weighted average 0.5 mg/m3;short term exposure limit 1.5 mg/m3, Skin, JUN2005

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Hazard Survey 1974Hazard Code M4224; Number of Industries 6; Total Number of Facilities 362; Number of Occupations 17; Total Number of Employees Exposed 7168

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
OSHA ANALYTICAL METHOD #45
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