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Phenol, 2,3,4,6 - tetrachloro -

RTECS #: SM9275000

CAS #: 58-90-2


UPDATE: May 2008 MW: 231.88 MF: C6H2Cl4O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 2,3,4,6 - Tetrachlorophenol
  2. 2,4,5,6 - Tetrachlorophenol
  1. Dowicide 6
  2. RCRA waste number U212


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster lung 250 mg/L MUREAV 241,175,1990
DNA damage human fibroblast 0.25 mmol/L/1 hour TOLED5 147,35,2004
mutation in mammalian somatic cells hamster lung 3,500 g/L CMSHAF 14,1617,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 300 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TXAPA9 28,146,1974


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
subcutaneous
mouse
lowest published toxic dose: 100 mg/kg Tumorigenic: Carcinogenic by RTECS criteria

Blood: Tumors
NTIS** PB223-159


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 82 mg/kg N/R VCVGK* -,245,1994
intraperitoneal
rat
lethal dose (50 percent kill): 130 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature increase
BJPCAL 13,20,1958
intraperitoneal
rat
lethal dose (50 percent kill): 130 mg/kg N/R VCVGK* -,245,1994
oral
dog
lethal dose (50 percent kill): 250 mg/kg N/R VCVGK* -,246,1994
oral
guinea pig
lethal dose (50 percent kill): 250 mg/kg N/R FMCHA2 -,C299,1991
oral
gerbil
lethal dose (50 percent kill): 698 mg/kg N/R ARTODN 40,63,1978
oral
mouse
lethal dose (50 percent kill): 30 mg/kg N/R VCVGK* -,245,1994
oral
rat
lethal dose (50 percent kill): 140 mg/kg N/R VCVGK* -,245,1994
oral
rat
lowest published toxic dose: 300 mg/kg Gastrointestinal: Other changes

Liver: Change in gall bladder structure or function

Liver: Other changes
VCVGK* -,248,1994
subcutaneous
rat
lowest published lethal dose: 210 mg/kg N/R HBTXAC 5,129,1959
skin
rat
lethal dose (50 percent kill): 485 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness
BECTA6 31,680,1983
skin
rat
lethal dose (50 percent kill): 485 mg/kg N/R VCVGK* -,245,1994
skin
rat
lethal dose (20 percent kill): 2 mg/kg/1 hour N/R VCVGK* -,248,1994
skin
rat
lethal dose (10 percent kill): 2 mg/kg/1 hour N/R VCVGK* -,248,1994
skin
rabbit
lethal dose (50 percent kill): 250 mg/kg N/R VCVGK* -,245,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 700 mg/kg/7 day- intermittent Liver: Other changes

Gastrointestinal: Other changes

Liver: Change in gall bladder structure or function
VCVGK* -,248,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Human Limited Evidence IMEMDT 41,319,1986


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - FINLAND time-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWEDEN time-weighted average 0.5 mg/m3;
short term exposure limit 1.5 mg/m3, Skin, JUN2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M4224;
Number of Industries 6;
Total Number of Facilities 362;
Number of Occupations 17;
Total Number of Employees Exposed 7,168


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as disinfectant and as preservative for wood, latex and leather
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #45


REFERENCES:

CODEN
REFERENCE

ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM.
CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as disinfectant and as preservative for wood, latex and leather

NOISH PROFILE (CHLOROPHENOLS), SRC, 3/81

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

ALT CAS #: 12698-64-5
Click Here for Additional Information about RTECS

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