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Registry of Toxic Effects of Chemical Substances (RTECS)

Phenol, pentachloro-, sodium salt

RTECS #

SM6490000

CAS #

131-52-2

Updated

December 2012

Molecular Weight

288.30

Molecular Formula

C6Cl5O·Na

Synonyms

Dow dormant fungicide
Dowicide G
Dowicide G-ST
GR 48-11PS
GR 48-32S
Mystox D
Napclor-G
Pentachlorophenate sodium
Pentachlorophenol, sodium salt
Pentachlorophenol, sodium salt, aerosol
Pentachlorophenol, sodium salt, technical grade
Pentachlorophenoxy sodium
Pentanot 25
Pentaphenate
Preventol PN
Santobrite
Sapco 25
Sodium PCP
Sodium pentachlorophenol
Sodium pentachlorophenolate
Sodium pentachlorophenoxide
Sodium pentachlorphenate
Sodium, (pentachlorophenoxy)-
Weedbeads
Witophen N

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA repair/Bacillus subtilis5 µg/discMUREAV 40,19,1976
micronucleus testmultiple/non-mammalian species10 µg/L/4D-continuousMUREAV 465,145,2000
micronucleus testmultiple/non-mammalian species100 µg/L/7D-continuousMUREAV 465,145,2000

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 360 mg/kg (8-19D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
CHYCDW 13,8,1979

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lethal concentration (50 percent kill): 341 mg/m3/2H85GMAT -,106,1982
inhalation/mouse lethal concentration (50 percent kill): 240 mg/m3/2H85GMAT -,106,1982
inhalation/rat Lowest published lethal concentration: 10 mg/kg/28MHBPTO* 2,1486,2001
inhalation/rat Lowest published lethal concentration: 14.5 mg/kg/44MHBPTO* 2,1486,2001
intraperitoneal/mouse lethal dose (50 percent kill): 63700 µg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory stimulation

Skin and Appendages: Other: Hair
OSDIAF 5,119,1956
intraperitoneal/rabbit lowest published lethal dose: 50 mg/kgJIHTAB 23,239,1941
intratracheal/guinea pig lowest published lethal dose: 120 mg/kgMZUZA8 (9),29,1959
intratracheal/mouse lowest published lethal dose: 164 mg/kgMZUZA8 (9),29,1959
intratracheal/rat lowest published lethal dose: 146 mg/kgMZUZA8 (9),29,1959
intravenous/rabbit lowest published lethal dose: 22 mg/kgVascular: BP elevation not characterized in autonomic section

Endocrine: Hyperglycemia

Nutritional and Gross Metabolic: Body temperature increase
JPETAB 76,104,1942
oral/guinea pig lowest published lethal dose: 250 mg/kgMZUZA8 (9),29,1959
oral/mouse lethal dose (50 percent kill): 197 mg/kg85GMAT -,106,1982
oral/rabbit lethal dose (50 percent kill): 328 mg/kgMZUZA8 (9),29,1959
oral/rat lethal dose (50 percent kill): 126 mg/kgCHYCDW 13,8,1979
skin/guinea pig lowest published lethal dose: 266 mg/kgHBTXAC 5,125,1959
skin/mouse lethal dose (50 percent kill): 124 mg/kg85GMAT -,106,1982
skin/rabbit lowest published lethal dose: 250 mg/kgVascular: BP elevation not characterized in autonomic section

Endocrine: Hyperglycemia

Nutritional and Gross Metabolic: Body temperature increase
JPETAB 76,104,1942
subcutaneous/Dog lowest published lethal dose: 135 mg/kgHBTXAC 5,125,1959
subcutaneous/mouse lowest published lethal dose: 56 mg/kgHBTXAC 5,125,1959
subcutaneous/rabbit lowest published lethal dose: 100 mg/kgVascular: BP elevation not characterized in autonomic section

Endocrine: Hyperglycemia

Nutritional and Gross Metabolic: Body temperature increase
JPETAB 76,104,1942
subcutaneous/rat lethal dose (50 percent kill): 66 mg/kgVascular: BP elevation not characterized in autonomic section

Endocrine: Hyperglycemia

Nutritional and Gross Metabolic: Body temperature increase
JPETAB 76,104,1942

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 500 mg/m3/13W- intermittentLiver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
MZUZA8 (9),29,1959
inhalation/mouse lowest published toxic concentration: 500 mg/m3/13W- intermittentLiver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
MZUZA8 (9),29,1959
inhalation/rabbit lowest published toxic concentration: 500 mg/m3/13W- intermittentLung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
MZUZA8 (9),29,1959
inhalation/rat lowest published toxic concentration: 500 mg/m3/13W- intermittentLung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
MZUZA8 (9),29,1959
inhalation/rat lowest published toxic concentration: 500 mg/m3/4H/90D- intermittentLiver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,249,1994
oral/rat lowest published toxic dose: 84 mg/kg/28D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)HBPTO* 2,1493,2001

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,197,1998
Occupational Exposure Limit-FRANCEVME 0.5 mg/m3, Skin, C3 Carcinogen, FEB2006
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.1 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.5 mg/m3;short term exposure limit 1.5 mg/m3, Skin, JUN2005

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 69270; Number of Industries 21; Total Number of Facilities 1439; Number of Occupations 30; Total Number of Employees Exposed 16153; Total Number of Female Employees Exposed 1615
National Occupational Hazard Survey 1974Hazard Code 69270; Number of Industries 49; Total Number of Facilities 3778; Number of Occupations 46; Total Number of Employees Exposed 23402

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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