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Registry of Toxic Effects of Chemical Substances (RTECS)

Phenol, 4-octyl-

RTECS #

SM5787000

CAS #

1806-26-4

Updated

July 2013

Molecular Weight

206.33

Molecular Formula

C14H22O

Synonyms

4-Octylphenol
Octylphenol
p-Octylphenol

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster0.15 mmol/L/3HMUREAV 649,114,2008
DNA Damageovary/hamster0.2 mmol/L/1HMUREAV 649,114,2008
sister chromatid exchangeovary/hamster0.1 mmol/L/3HMUREAV 649,114,2008

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intravenous/domestic animal 7000 µg/kg (111-117D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects to embryo or fetus

Reproductive: Specific developmental abnormalities: Urogenital system
JRFAB* Jul,19,2000
oral/rat 157.5 mg/kg (multigeneration)Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Effects on newborn: Biochemical and metabolic
ETOPFR 23,73,2007
oral/rat 7250 mg/kg (1-22D preg/7D after birth)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Physical
JRPFA4 26,25,2000
oral/rat 11600 mg/kg (2W pre-22D after birth)Reproductive: Specific developmental abnormalities: Urogenital systemEVHPAZ 103,1136,1995
oral/rat 22 µg/kg (22D after birth)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)EVHPAZ 103,1136,1995
oral/rat 220 µg/kg (22D after birth)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Delayed effects
EVHPAZ 103,1136,1995
oral/rat 570 µg/kg (2W pre-22W after birth)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects
EVHPAZ 103,1136,1995
oral/rat 1130 µg/kg (10W pre-22D after birth)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)EVHPAZ 103,1136,1995
oral/rat 11.3 mg/kg (10W pre-22D after birth)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Delayed effects
EVHPAZ 103,1136,1995
subcutaneous/domestic animal 60000 µg/kg (60D after birth)Reproductive: Effects on newborn: Germ cell effects (in offspring)

Reproductive: Effects on newborn: Delayed effects
JRFAB* Jul,18,2000
subcutaneous/mouse 0.3 mg/kg (10-14D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TOLED5 181,13,2008

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 60 mg/kgLiver: Other changesTXCYAC 175,49,2002
oral/rat lethal dose (50 percent kill): 1.2 gm/kgEye: Chromodacryorrhea

Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea
HPV110 -,-,2001

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 600 mg/kg/10D- intermittentLiver: Other changes

Biochemical: Metabolism (intermediary): Other proteins

Related to Chronic Data: Changes in testicular weight
TXCYAC 175,49,2002
oral/rat lowest published toxic dose: 400 mg/kg/4D- intermittentReproductive: Maternal effects: Uterus, cervix, vaginaREPTED 17,421,2003
oral/rat lowest published toxic dose: 62.5 mg/kg/5D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in prostate weight
REPTED 15,683,2001
oral/rat lowest published toxic dose: 1000 mg/kg/5D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldREPTED 15,683,2001
oral/rat lowest published toxic dose: 250 mg/kg/5D- intermittentReproductive: Effects on newborn: PhysicalREPTED 15,683,2001
oral/rat lowest published toxic dose: 250 mg/kg/5D- intermittentReproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glandsREPTED 15,683,2001
oral/rat lowest published toxic dose: 250 mg/kg/5D- intermittentReproductive: Maternal effects: Uterus, cervix, vaginaREPTED 15,683,2001
oral/rat lowest published toxic dose: 500 mg/kg/5D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field

Related to Chronic Data: Changes in testicular weight
REPTED 15,683,2001
subcutaneous/rat lowest published toxic dose: 1500 mg/kg/3D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductasesCMSHAF 50,1167,2003

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWTOLED5 131,75,2002
TOXICOLOGY REVIEWBPCEM* 16,105,2002
TOXICOLOGY REVIEWJTPAE7 17,69,2004
TOXICOLOGY REVIEWHTOPA* 1,501,2002
TOXICOLOGY REVIEWTXCYAC 285,83,2011
TOXICOLOGY REVIEWREPTED 38,1,2013
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