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Phenol, 4 - octyl -

RTECS #: SM5787000

CAS #: 1806-26-4


UPDATE: May 2009 MW: 206.33 MF: C14H22O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. REFERENCES:

SYNONYMS:

  1. 4 - Octylphenol
  2. Octylphenol
  1. p - Octylphenol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 0.15 mmol/L/3 hour MUREAV 649,114,2008
DNA damage hamster ovary 0.2 mmol/L/1 hour MUREAV 649,114,2008
sister chromatid exchange hamster ovary 0.1 mmol/L/3 hour MUREAV 649,114,2008


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intravenous
domestic animal
lowest published toxic dose: 7,000 g/kg (111-117 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects to embryo or fetus

Reproductive: Specific developmental abnormalities: Urogenital system
JRFAB* Jul,19,2000
oral
rat
lowest published toxic dose: 11,600 mg/kg (2 week prior to copulation-22 day after birth) Reproductive: Specific developmental abnormalities: Urogenital system EVHPAZ 103,1136,1995
oral
rat
lowest published toxic dose: 22 g/kg (22 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) EVHPAZ 103,1136,1995
oral
rat
lowest published toxic dose: 220 g/kg (22 day after birth) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Delayed effects
EVHPAZ 103,1136,1995
oral
rat
lowest published toxic dose: 570 g/kg (2 week prior to copulation-22 week after birth) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects
EVHPAZ 103,1136,1995
oral
rat
lowest published toxic dose: 1,130 g/kg (10 week prior to copulation-22 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) EVHPAZ 103,1136,1995
oral
rat
lowest published toxic dose: 11.3 mg/kg (10 week prior to copulation-22 day after birth) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Delayed effects
EVHPAZ 103,1136,1995
oral
rat
lowest published toxic dose: 7,250 mg/kg (1-22 day pregnant/7 day after birth) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Physical
JRPFA4 26,25,2000
oral
rat
lowest published toxic dose: 157.5 mg/kg (multigeneration) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Effects on newborn: Biochemical and metabolic
ETOPFR 23,73,2007
subcutaneous
domestic animal
lowest published toxic dose: 60,000 g/kg (60 day after birth) Reproductive: Effects on newborn: Germ cell effects (in offspring)

Reproductive: Effects on newborn: Delayed effects
JRFAB* Jul,18,2000


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 60 mg/kg Liver: Other changes TXCYAC 175,49,2002


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 600 mg/kg/10 day- intermittent Liver: Other changes

Biochemical: Metabolism (intermediary): Other proteins

Related to Chronic Data: Changes in testicular weight
TXCYAC 175,49,2002
oral
rat
lowest published toxic dose: 62.5 mg/kg/5 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in prostate weight
REPTED 15,683,2001
oral
rat
lowest published toxic dose: 1,000 mg/kg/5 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field REPTED 15,683,2001
oral
rat
lowest published toxic dose: 250 mg/kg/5 day- intermittent Reproductive: Effects on newborn: Physical REPTED 15,683,2001
oral
rat
lowest published toxic dose: 250 mg/kg/5 day- intermittent Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands REPTED 15,683,2001
oral
rat
lowest published toxic dose: 250 mg/kg/5 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina REPTED 15,683,2001
oral
rat
lowest published toxic dose: 500 mg/kg/5 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field

Related to Chronic Data: Changes in testicular weight
REPTED 15,683,2001
oral
rat
lowest published toxic dose: 400 mg/kg/4 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina REPTED 17,421,2003
subcutaneous
rat
lowest published toxic dose: 1,500 mg/kg/3 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases CMSHAF 50,1167,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
TOLED5 131,75,2002
TOXICOLOGY REVIEW
BPCEM* 16,105,2002
TOXICOLOGY REVIEW
JTPAE7 17,69,2004
TOXICOLOGY REVIEW
HTOPA* 1,501,2002
TOXICOLOGY REVIEW
HTOPA* 1,501,2002
TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

N/R


REFERENCES:

CODEN
REFERENCE

BPCEM* Best Practice & Research Clinical Endocrinology and Metabolism (Elsevier Ltd.) V.13- 1999-
CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972-
ETOPFR Environmental Toxicology and Pharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Feb.1996-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
HTOPA*
JRFAB* Journal of reproduction and fertility. Abstract series. (Cambridge, U.K. : Journals of Reproduction and Fertility Ltd. ; Colchester, U.K. : Biochemical Society Book Depot (distributor)) V.1-26 1988-2000. Continued by: Reproduction (Cambridge, England). Abstract series
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

RTECS Compound Description:
   Mutagen
   Reproductive Effector

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