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Registry of Toxic Effects of Chemical Substances (RTECS)

Phenol, nonyl-

RTECS #

SM5600000

CAS #

25154-52-3

Updated

July 2013

Molecular Weight

220.39

Molecular Formula

C15H24O

Synonyms

Hydroxyl No. 253
Monononylphenol
n-Nonylphenol
Nonyl phenol (mixed isomers)
Nonylphenol
Nonylphenol mixture

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 500 mg open irritation test moderateUCDS** 6/9/1959

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 19 gm/kg (21D male/21D pre-13D after birth)Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
REPTED 15,293,2001
oral/rat 154 mg/kg (21D male/21D pre-2W after birth)Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system
REPTED 15,293,2001
oral/rat 4 gm/kg (21D male/21D pre-13D after birth)Reproductive: Specific developmental abnormalities: Gastrointestinal system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
REPTED 15,293,2001
oral/rat 770 mg/kg (21D male/21D pre-2W after birth)Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system
REPTED 15,293,2001
oral/rat 3850 mg/kg (multigeneration))Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system
REPTED 15,293,2001
oral/rat 154 mg/kg (multigeneration))Reproductive: Specific developmental abnormalities: Endocrine systemREPTED 15,293,2001
oral/rat 2 mg/kg (multigeneration))Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Effects on newborn: Biochemical and metabolic
FCTOD7 40,53,2002
oral/rat 2700 mg/kg (15-22D preg/10D after birth)Reproductive: Other effects on female

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
ARTODN 78,97,2004
oral/rat 116.25 mg/kg (7D preg-77D after birth)Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Other postnatal measures or effects

Reproductive: Effects on newborn: Delayed effects
TOXID9 60,29,2001
oral/rat 88.75 mg/kg (1D preg-50D after birth)Reproductive: Effects on newborn: Biochemical and metabolicTOXID9 1,73,2001
oral/rat 97.5 mg/kg (7D preg-64D after birth)Reproductive: Effects on newborn: Biochemical and metabolicTXCYAC 211,207,2005
oral/rat 7000 mg/kg (28D male)Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glandsARTODN 81,77,2007
oral/rat 7000 mg/kg (28D prior to copulation)Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Maternal effects: Menstrual cycle changes or disorders
ARTODN 81,77,2007

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/non-mammalian species lowest published toxic dose: 2.5 mg/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)TOXID9 72,192,2003
intraperitoneal/rat lowest published toxic dose: 60 mg/kgLiver: Other changesTXCYAC 175,49,2002
oral/mouse lethal dose (50 percent kill): 75.63 mL/kgEESADV 59,123,2004
oral/mouse lethal dose (50 percent kill): 1231 mg/kgNTIS** AD-A067-313
oral/rat lethal dose (50 percent kill): 580 mg/kgNTIS** OTS0573098
parenteral/non-mammalian species lowest published toxic dose: 250 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)REPTED 22,449,2006
skin/rabbit lethal dose (50 percent kill): 2140 µL/kgAIHAAP 30,470,1969
skin/rabbit lethal dose (50 percent kill): 2140 mg/kgVCVGK* -,223,1994

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/frog lowest published toxic dose: 2800 mg/kg/14D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type field

Endocrine: Other changes
BPBLEO 28,1748,2005
intraperitoneal/rat lowest published toxic dose: 600 mg/kg/10D- intermittentLiver: Other changes

Biochemical: Metabolism (intermediary): Other proteins

Related to Chronic Data: Changes in testicular weight
TXCYAC 175,49,2002
oral/mouse lowest published toxic dose: 525 mg/kg/7D- intermittentLiver: Other changes

Endocrine: Differential effect of sex or castration on observed toxicity

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TXCYAC 256,53,2009
oral/rat lowest published toxic dose: 1400 mg/kg/28D- intermittentEndocrine: Changes in thyroid weight

Blood: Changes in other cell count (unspecified)
ARTODN 81,77,2007
oral/rat lowest published toxic dose: 1400 mg/kg/28D- intermittentEndocrine: Change in LH

Endocrine: Hypoglycemia

Nutritional and Gross Metabolic: Changes in: Ca
ARTODN 81,77,2007
oral/rat lowest published toxic dose: 7000 mg/kg/28D- intermittentLiver: Multiple effects

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Normocytic anemia
ARTODN 81,77,2007
oral/rat lowest published toxic dose: 7000 mg/kg/28D- intermittentLiver: Multiple effects

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
ARTODN 81,77,2007
oral/rat lowest published toxic dose: 1589 mg/kg/29D- continuousNutritional and Gross Metabolic: Other changesNTIS** OTS0573098
oral/rat lowest published toxic dose: 14000 mg/kg/56D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
REPTED 15,293,2001
oral/rat lowest published toxic dose: 3500 mg/kg/2W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
REPTED 15,293,2001
oral/rat lowest published toxic dose: 4200 mg/kg/12W- intermittentKidney, Ureter, and Bladder: Changes in kidney weight

Liver: Changes in liver weight

Brain and Coverings: Changes in brain weight
REPTED 15,293,2001
oral/rat lowest published toxic dose: 168 mg/kg/12W- intermittentEndocrine: Androgenic

Reproductive: Paternal effects: Testes, epididymis, sperm duct
REPTED 15,293,2001
oral/rat lowest published toxic dose: 2800 mg/kg/56D- intermittentKidney, Ureter, and Bladder: Other changes

Reproductive: Maternal effects: Ovaries, fallopian tubes
REPTED 15,293,2001
oral/rat lowest published toxic dose: 112 mg/kg/56D- intermittentReproductive: Maternal effects: Uterus, cervix, vaginaREPTED 15,293,2001
oral/rat lowest published toxic dose: 3500 mg/kg/14D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldREPTED 15,293,2001
oral/rat lowest published toxic dose: 3000 mg/kg/30D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
TOLED5 143,261,2003
oral/rat lowest published toxic dose: 21 gm/kg/6W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type field

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
ETOPFR 17,19,2004
oral/rat lowest published toxic dose: 15750 mg/kg/6W- intermittentEndocrine: Changes in thymus weightETOPFR 17,19,2004
oral/rat lowest published toxic dose: 5250 mg/kg/6W- intermittentBiochemical: Metabolism (intermediary): OtherETOPFR 17,19,2004
oral/rat lowest published toxic dose: 2700 mg/kg/18D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainARTODN 78,97,2004
oral/rat lowest published toxic dose: 45 µg/kg/45D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Related to Chronic Data: Changes in testicular weight
ARTODN 76,545,2002
oral/rat lowest published toxic dose: 450 µg/kg/45D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Related to Chronic Data: Changes in testicular weight
ARTODN 76,545,2002
subcutaneous/mouse lowest published toxic dose: 300 mg/kg/3D- intermittentRelated to Chronic Data: Changes in uterine weight

Endocrine: Estrogenic
EVHPAZ 104,1296,1996
subcutaneous/pig lowest published toxic dose: 560 mg/kg/14D- intermittentReproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Uterus, cervix, vagina
REPTED 16,29,2002
subcutaneous/rat lowest published toxic dose: 300 mg/kg/3D- intermittentReproductive: Maternal effects: Uterus, cervix, vaginaREPTED 17,311,2003
unreported route/mouse lowest published toxic dose: 350 mg/kg/7D- intermittentLiver: Other changes

Endocrine: Differential effect of sex or castration on observed toxicity

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TOXID9 90,375,2006
unreported route/mouse lowest published toxic dose: 175 mg/kg/7D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
TOXID9 78,72,2004
unreported route/mouse lowest published toxic dose: 10080 mg/kg/32W- intermittentBehavioral: Tolerance

Liver: Other changes
TOXID9 78,72,2004

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWTOLED5 127,225,2002
TOXICOLOGY REVIEWTOLED5 131,75,2002
TOXICOLOGY REVIEWENTOX* -,260,2005
TOXICOLOGY REVIEWARTODN 81,227,2007
TOXICOLOGY REVIEWJTEHD6 7,1,2004
TOXICOLOGY REVIEWREPTED 23,337,2007
TOXICOLOGY REVIEWJTPAE7 17,69,2004
TOXICOLOGY REVIEWHTOPA* 1,501,2002
TOXICOLOGY REVIEWMUREAV 681,3,2009
TOXICOLOGY REVIEWTPHSDY 29,116,2008
TOXICOLOGY REVIEWMUREAV 681,51,2009
TOXICOLOGY REVIEWREPTED 38,1,2013

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83208; Number of Industries 151; Total Number of Facilities 27721; Number of Occupations 108; Total Number of Employees Exposed 306211; Total Number of Female Employees Exposed 42765
National Occupational Hazard Survey 1974Hazard Code 83208; Number of Industries 58; Total Number of Facilities 3891; Number of Occupations 60; Total Number of Employees Exposed 67708

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9019
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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