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Phenol, nonyl -

RTECS #: SM5600000

CAS #: 25154-52-3


UPDATE: May 2009 MW: 220.39 MF: C15H24O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Hydroxyl No. 253
  2. Monononylphenol
  3. Nonyl phenol (mixed isomers)
  1. Nonylphenol
  2. Nonylphenol mixture
  3. n - Nonylphenol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
500 mg open irritation test moderate UCDS** 6/9/1959


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 19 gm/kg (21 day male/21 day prior to copulation-13 day after birth) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
REPTED 15,293,2001
oral
rat
lowest published toxic dose: 154 mg/kg (21 day male/21 day prior to copulation-2 week after birth) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system
REPTED 15,293,2001
oral
rat
lowest published toxic dose: 4 gm/kg (21 day male/21 day prior to copulation-13 day after birth) Reproductive: Specific developmental abnormalities: Gastrointestinal system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
REPTED 15,293,2001
oral
rat
lowest published toxic dose: 770 mg/kg (21 day male/21 day prior to copulation-2 week after birth) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system
REPTED 15,293,2001
oral
rat
lowest published toxic dose: 3,850 mg/kg (multigeneration)) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system
REPTED 15,293,2001
oral
rat
lowest published toxic dose: 154 mg/kg (multigeneration)) Reproductive: Specific developmental abnormalities: Endocrine system REPTED 15,293,2001
oral
rat
lowest published toxic dose: 2 mg/kg (multigeneration)) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Effects on newborn: Biochemical and metabolic
FCTOD7 40,53,2002
oral
rat
lowest published toxic dose: 2,700 mg/kg (15-22 day pregnant/10 day after birth) Reproductive: Other effects on female

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
ARTODN 78,97,2004
oral
rat
lowest published toxic dose: 116.25 mg/kg (7 day pregnant-77 day after birth) Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Other postnatal measures or effects

Reproductive: Effects on newborn: Delayed effects
TOXID9 60,29,2001
oral
rat
lowest published toxic dose: 88.75 mg/kg (1 day pregnant-50 day after birth) Reproductive: Effects on newborn: Biochemical and metabolic TOXID9 1,73,2001
oral
rat
lowest published toxic dose: 97.5 mg/kg (7 day pregnant-64 day after birth) Reproductive: Effects on newborn: Biochemical and metabolic TXCYAC 211,207,2005
oral
rat
lowest published toxic dose: 7,000 mg/kg (28 day male) Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands ARTODN 81,77,2007
oral
rat
lowest published toxic dose: 7,000 mg/kg (28 day prior to copulation) Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Maternal effects: Menstrual cycle changes or disorders
ARTODN 81,77,2007


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
non-mammalian species
lowest published toxic dose: 2.5 mg/kg Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) TOXID9 72,192,2003
intraperitoneal
rat
lowest published toxic dose: 60 mg/kg Liver: Other changes TXCYAC 175,49,2002
oral
mouse
lethal dose (50 percent kill): 1,231 mg/kg N/R NTIS** AD-A067-313
oral
mouse
lethal dose (50 percent kill): 75.63 mL/kg N/R EESADV 59,123,2004
oral
rat
lethal dose (50 percent kill): 580 mg/kg N/R NTIS** OTS0573098
parenteral
non-mammalian species
lowest published toxic dose: 250 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) REPTED 22,449,2006
skin
rabbit
lethal dose (50 percent kill): 2,140 L/kg N/R AIHAAP 30,470,1969
skin
rabbit
lethal dose (50 percent kill): 2,140 mg/kg N/R VCVGK* -,223,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
frog
lowest published toxic dose: 2,800 mg/kg/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field

Endocrine: Other changes
BPBLEO 28,1748,2005
intraperitoneal
rat
lowest published toxic dose: 600 mg/kg/10 day- intermittent Liver: Other changes

Biochemical: Metabolism (intermediary): Other proteins

Related to Chronic Data: Changes in testicular weight
TXCYAC 175,49,2002
oral
rat
lowest published toxic dose: 1,589 mg/kg/29 day- continuous Nutritional and Gross Metabolic: Other changes NTIS** OTS0573098
oral
rat
lowest published toxic dose: 14,000 mg/kg/56 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
REPTED 15,293,2001
oral
rat
lowest published toxic dose: 3,500 mg/kg/2 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
REPTED 15,293,2001
oral
rat
lowest published toxic dose: 4,200 mg/kg/12 week- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight

Liver: Changes in liver weight

Brain and Coverings: Changes in brain weight
REPTED 15,293,2001
oral
rat
lowest published toxic dose: 168 mg/kg/12 week- intermittent Endocrine: Androgenic

Reproductive: Paternal effects: Testes, epididymis, sperm duct
REPTED 15,293,2001
oral
rat
lowest published toxic dose: 2,800 mg/kg/56 day- intermittent Kidney, Ureter, and Bladder: Other changes

Reproductive: Maternal effects: Ovaries, fallopian tubes
REPTED 15,293,2001
oral
rat
lowest published toxic dose: 112 mg/kg/56 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina REPTED 15,293,2001
oral
rat
lowest published toxic dose: 3,500 mg/kg/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field REPTED 15,293,2001
oral
rat
lowest published toxic dose: 3,000 mg/kg/30 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
TOLED5 143,261,2003
oral
rat
lowest published toxic dose: 21 gm/kg/6 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
ETOPFR 17,19,2004
oral
rat
lowest published toxic dose: 15,750 mg/kg/6 week- intermittent Endocrine: Changes in thymus weight ETOPFR 17,19,2004
oral
rat
lowest published toxic dose: 5,250 mg/kg/6 week- intermittent Biochemical: Metabolism (intermediary): Other ETOPFR 17,19,2004
oral
rat
lowest published toxic dose: 2,700 mg/kg/18 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain ARTODN 78,97,2004
oral
rat
lowest published toxic dose: 45 g/kg/45 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Related to Chronic Data: Changes in testicular weight
ARTODN 76,545,2002
oral
rat
lowest published toxic dose: 450 g/kg/45 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Related to Chronic Data: Changes in testicular weight
ARTODN 76,545,2002
oral
rat
lowest published toxic dose: 1,400 mg/kg/28 day- intermittent Endocrine: Changes in thyroid weight

Blood: Changes in other cell count (unspecified)
ARTODN 81,77,2007
oral
rat
lowest published toxic dose: 1,400 mg/kg/28 day- intermittent Endocrine: Change in LH

Endocrine: Hypoglycemia

Nutritional and Gross Metabolic: Changes in: Ca
ARTODN 81,77,2007
oral
rat
lowest published toxic dose: 7,000 mg/kg/28 day- intermittent Liver: Multiple effects

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Normocytic anemia
ARTODN 81,77,2007
oral
rat
lowest published toxic dose: 7,000 mg/kg/28 day- intermittent Liver: Multiple effects

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
ARTODN 81,77,2007
subcutaneous
mouse
lowest published toxic dose: 300 mg/kg/3 day- intermittent Related to Chronic Data: Changes in uterine weight

Endocrine: Estrogenic
EVHPAZ 104,1296,1996
subcutaneous
pig
lowest published toxic dose: 560 mg/kg/14 day- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Uterus, cervix, vagina
REPTED 16,29,2002
subcutaneous
rat
lowest published toxic dose: 300 mg/kg/3 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina REPTED 17,311,2003
unreported route
mouse
lowest published toxic dose: 175 mg/kg/7 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
TOXID9 78,72,2004
unreported route
mouse
lowest published toxic dose: 10,080 mg/kg/32 week- intermittent Behavioral: Tolerance

Liver: Other changes
TOXID9 78,72,2004
unreported route
mouse
lowest published toxic dose: 350 mg/kg/7 day- intermittent Liver: Other changes

Endocrine: Differential effect of sex or castration on observed toxicity

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TOXID9 90,375,2006


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
TOLED5 127,225,2002
TOXICOLOGY REVIEW
TOLED5 131,75,2002
TOXICOLOGY REVIEW
ENTOX* -,260,2005
TOXICOLOGY REVIEW
ARTODN 81,227,2007
TOXICOLOGY REVIEW
JTEHD6 7,1,2004
TOXICOLOGY REVIEW
REPTED 23,337,2007
TOXICOLOGY REVIEW
JTPAE7 17,69,2004
TOXICOLOGY REVIEW
HTOPA* 1,501,2002
TOXICOLOGY REVIEW
MUREAV 681,3,2009


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83208;
Number of Industries 58;
Total Number of Facilities 3,891;
Number of Occupations 60;
Total Number of Employees Exposed 67,708
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83208;
Number of Industries 151;
Total Number of Facilities 27,721;
Number of Occupations 108;
Total Number of Employees Exposed 306,211;
Total Number of Female Employees Exposed 42,765


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in manufacture of synthetic organic detergents, synthetic rubber and oil additives
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9019
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993-
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ETOPFR Environmental Toxicology and Pharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Feb.1996-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
HTOPA*
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used in manufacture of synthetic organic detergents, synthetic rubber and oil additives

RTECS Compound Description:
   Reproductive Effector
   Primary Irritant

Click Here for Additional Information about RTECS

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