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Registry of Toxic Effects of Chemical Substances (RTECS)

Phenol, p-nitro-

RTECS #

SM2275000

CAS #

100-02-7

Updated

September 201

Molecular Weight

139.12

Molecular Formula

C6H5NO3

Synonyms

4-Hydroxynitrobenzene
4-Nitrofenol (Dutch)
4-Nitrophenol
NCI-C55992
Niphen
Paranitrofenol (Dutch)
Paranitrofenolo (Italian)
Paranitrophenol (French,German)
p-Nitrofenol (Czech)
p-Nitrophenol
RCRA waste number U170

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster1500 mg/L/10.5H (+enzymatic activation step)HPV084 -,-,2003
DNA adduct/Escherichia coli50 µmol/LMUREAV 89,95,1981
DNA Damageliver/rat700 µmol/LEMMUEG 24,181,1994
DNA repair/Bacillus subtilis500 µg/discMUREAV 170,11,1986
DNA repair/Other microorganisms10 mg/plateBIZNAT 95,463,1976
gene conversion and mitotic recombination/Saccharomyes cerevisiae21 mmol/LIARCCD 10,161,1974
micronucleus testovary/hamster569 mg/L/3H (+enzymatic activation step)MUREAV 742,11,2012
micronucleus testlung/hamster500 mg/L/3H (+enzymatic activation step)MUREAV 742,11,2012
micronucleus testliver/human782 mg/L/3H (+enzymatic activation step)MUREAV 742,11,2012

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intracerebral/mouse lethal dose (50 percent kill): 90 mg/kgPCBPBS 8,302,1978
intramuscular/pigeon lowest published lethal dose: 65 mg/kgJPETAB 49,187,1933
intraperitoneal/mouse lethal dose (50 percent kill): 75 mg/kgNTIS** AD691-490
intravenous/Dog lowest published lethal dose: 10 mg/kgXPHBAO 271,131,1941
oral/mammal (species unspecified) lethal dose (50 percent kill): 247 mg/kgGISAAA 45(10),16,1980
oral/mouse lethal dose (50 percent kill): 282 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold
NTIS** OTS0570918
oral/rabbit lowest published lethal dose: 600 mg/kgGastrointestinal: Changes in structure or function of salivary glands

Behavioral: Ataxia
NTIS** 0TS0518150
oral/rat lethal dose (50 percent kill): 202 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
NTIS** 0TS0518152
oral/rat lethal dose (50 percent kill): 230 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
HPV084 -,-,2003
skin/guinea pig lethal dose (50 percent kill): >1 gm/kgSkin: After systemic exposure: Dermatitis, otherNTIS** OTS0570918
skin/mammal (species unspecified) lethal dose (50 percent kill): 920 mg/kgGISAAA 45(10),16,1980
skin/rabbit lethal dose (50 percent kill): >5000 mg/kgHPV084 -,-,2003
skin/rabbit lowest published lethal dose: 1500 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness
NTIS** 0TS0518150
skin/rat lethal dose (50 percent kill): 1024 mg/kgNTIS** 0TS0516686
subcutaneous/frog lowest published lethal dose: 60 mg/kgBehavioral: Tremor

Behavioral: Muscle weakness

Behavioral: Ataxia
RMSRA6 16,449,1896
subcutaneous/guinea pig lowest published lethal dose: 200 mg/kgBehavioral: Muscle weakness

Behavioral: Coma
RMSRA6 16,449,1896
subcutaneous/rat lowest published lethal dose: 200 mg/kgBehavioral: Muscle weakness

Behavioral: Coma
RMSRA6 16,449,1896
unreported route/cat lethal dose (50 percent kill): 150 mg/kg30ZDA9 -,97,1971
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 175 mg/kgGISAAA 39(11),13,1974

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 30 mg/m3/4W- intermittentEye: Corneal damageHPV084 -,-,2003
oral/rat lowest published toxic dose: 6370 mg/kg/13W- intermittentLung, Thorax, or Respiration: Dyspnea

Liver: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV084 -,-,2003
oral/rat lowest published toxic dose: 63700 mg/kg/13W- continuousBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0526338
oral/rat lowest published toxic dose: 4140 mg/kg/18D- intermittentBehavioral: Convulsions or effect on seizure thresholdJTSCDR 26,299,2001
oral/rat lowest published toxic dose: 11.2 gm/kg/28D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)JTSCDR 26,299,2001
oral/rat lowest published toxic dose: 28 gm/kg/28D- intermittentBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JTSCDR 26,299,2001
oral/rat lowest published toxic dose: 2880 mg/kg/18D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTOXID9 66,152,2002
oral/rat lowest published toxic dose: 28 gm/kg/28D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTOXID9 66,152,2002
oral/rat lowest published toxic dose: 11200 mg/kg/28D- intermittentKidney, Ureter, and Bladder: Other changesTOXID9 66,152,2002
subcutaneous/rat lowest published toxic dose: 70 mg/kg/7D- intermittentRelated to Chronic Data: Changes in uterine weightTXAPA9 217,1,2006
subcutaneous/rat lowest published toxic dose: 0.05 mg/kg/5D- intermittentReproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Related to Chronic Data: Changes in prostate weight
TXAPA9 217,1,2006
subcutaneous/rat lowest published toxic dose: 0.5 mg/kg/5D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Change in LH
TXAPA9 217,1,2006

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 47,75,1978
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWMUTAEX 21,225,2006
TOXICOLOGY REVIEWMUREAV 653,99,2008
TOXICOLOGY REVIEWMUREAV 752,99,2013

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,195,1998
Occupational Exposure Limit-RUSSIAtime-weighted average 1 mg/m3, short term exposure limit 3 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 50940; Number of Industries 2; Total Number of Facilities 116; Number of Occupations 4; Total Number of Employees Exposed 2154; Total Number of Female Employees Exposed 1553
National Occupational Hazard Survey 1974Hazard Code 50940; Number of Industries 4; Total Number of Facilities 204; Number of Occupations 6; Total Number of Employees Exposed 635

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/110823/AS)
EPA GENETOX PROGRAM 1988, Inconclusive: Host-mediated assay
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (derm);no evidence:mouse
On EPA IRIS database
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