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Registry of Toxic Effects of Chemical Substances (RTECS)

Phenol, o-nitro-

RTECS #

SM2100000

CAS #

88-75-5

Updated

February 2006

Molecular Weight

139.12

Molecular Formula

C6H5NO3

Synonyms

2-Hydroxynitrobenzene
2-Nitrophenol
o-Nitrofenol (Czech)
Phenol, 2-nitro-

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intramuscular/mouse lowest published lethal dose: 600 mg/kgHBTXAC 5,120,1959
intraperitoneal/mouse lethal dose (50 percent kill): 378 mg/kgJMCMAR 18,868,1975
intraperitoneal/rat lethal dose (50 percent kill): 840 mg/kgBehavioral: Coma

Lung, Thorax, or Respiration: Dyspnea

Kidney, Ureter, and Bladder: Structural or functional change in ureter
NTIS** OTS0545982
intravenous/Dog lethal dose (50 percent kill): 100 mg/kg85JCAE -,675,1986
oral/mouse lethal dose (50 percent kill): 1297 mg/kgAMRL** TR-72-62,1972
oral/rat lethal dose (50 percent kill): 334 mg/kgGTPPAF 8,145,1972
skin/rabbit lethal dose (50 percent kill): >7940 mg/kgBehavioral: Food intake (animal)

Behavioral: Change in motor activity (specific assay)
ATDAEI 1,74,1990
subcutaneous/cat lowest published lethal dose: 600 mg/kgHBTXAC 5,120,1959
subcutaneous/frog lowest published lethal dose: 300 mg/kgHBTXAC 5,120,1959
subcutaneous/guinea pig lowest published lethal dose: 900 mg/kgBehavioral: Muscle weakness

Behavioral: Coma
RMSRA6 16,449,1896
subcutaneous/rabbit lowest published lethal dose: 1700 mg/kgHBTXAC 5,120,1959
subcutaneous/rat lowest published lethal dose: 1100 mg/kgBehavioral: Muscle weakness

Behavioral: Coma
RMSRA6 16,449,1896

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 47,75,1978

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAtime-weighted average 3 mg/m3, short term exposure limit 6 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 50950; Number of Industries 1; Total Number of Facilities 6; Number of Occupations 1; Total Number of Employees Exposed 80
National Occupational Hazard Survey 1974Hazard Code 50950; Number of Industries 1; Total Number of Facilities 33; Number of Occupations 1; Total Number of Employees Exposed 132

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/110823/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9294
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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