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Phenol, o - nitro -

RTECS #: SM2100000

CAS #: 88-75-5


UPDATE: February 2006 MW: 139.12 MF: C6H5NO3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. REVIEWS:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 2 - Hydroxynitrobenzene
  2. 2 - Nitrophenol
  1. Phenol, 2 - nitro -
  2. o - Nitrofenol (Czech)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intramuscular
mouse
lowest published lethal dose: 600 mg/kg N/R HBTXAC 5,120,1959
intraperitoneal
mouse
lethal dose (50 percent kill): 378 mg/kg N/R JMCMAR 18,868,1975
intraperitoneal
rat
lethal dose (50 percent kill): 840 mg/kg Behavioral: Coma

Lung, Thorax, or Respiration: Dyspnea

Kidney, Ureter, and Bladder: Structural or functional change in ureter
NTIS** OTS0545982
intravenous
dog
lethal dose (50 percent kill): 100 mg/kg N/R 85JCAE -,675,1986
oral
mouse
lethal dose (50 percent kill): 1,297 mg/kg N/R AMRL** TR-72-62,1972
oral
rat
lethal dose (50 percent kill): 334 mg/kg N/R GTPPAF 8,145,1972
subcutaneous
cat
lowest published lethal dose: 600 mg/kg N/R HBTXAC 5,120,1959
subcutaneous
frog
lowest published lethal dose: 300 mg/kg N/R HBTXAC 5,120,1959
subcutaneous
guinea pig
lowest published lethal dose: 900 mg/kg Behavioral: Muscle weakness

Behavioral: Coma
RMSRA6 16,449,1896
subcutaneous
rat
lowest published lethal dose: 1,100 mg/kg Behavioral: Muscle weakness

Behavioral: Coma
RMSRA6 16,449,1896
subcutaneous
rabbit
lowest published lethal dose: 1,700 mg/kg N/R HBTXAC 5,120,1959
skin
rabbit
lethal dose (50 percent kill): >7,940 mg/kg Behavioral: Food intake (animal)

Behavioral: Change in motor activity (specific assay)
ATDAEI 1,74,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
MUREAV 47,75,1978


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA time-weighted average 3 mg/m3, short term exposure limit 6 mg/m3, Skin, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 50950;
Number of Industries 1;
Total Number of Facilities 33;
Number of Occupations 1;
Total Number of Employees Exposed 132
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 50950;
Number of Industries 1;
Total Number of Facilities 6;
Number of Occupations 1;
Total Number of Employees Exposed 80


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/110823/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in synthesis of o-AMINOPHENOL, o-NITROANISOLE and other dyestuffs
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9294
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AMRL** Aerospace Medical Research Laboratory Report. (Aerospace Technical Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH 45433)
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
GTPPAF Gigiena Truda i Professional'naya Patologiya v Estonskoi SSR. Labor Hygiene and Occupational Pathology in the Estonian SSR. (Institut Eksperimental'noi i Klinicheskoi Meditsiny Ministerstva Zdravookhraneniya Estonskoi SSR, Tallinn, USSR) V.8- 1972-
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RMSRA6 Revue Medicale de la Suisse Romande. (Societe Medicale de La Suisse Romande, 2 rue Bellefontaine, 1003 Lausanne, Switzerland) V.1- 1881-

Used in synthesis of o-AMINOPHENOL, o-NITROANISOLE and other dyestuffs

NIOSH PROFILE (NITROPHENOLS), SRC, 4/81

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