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Registry of Toxic Effects of Chemical Substances (RTECS)

Phenol, p-methylamino-, sulfate (salt)

RTECS #

SL8650000

CAS #

55-55-0

Updated

October 2002

Molecular Weight

219.23

Molecular Formula

C7H9NO·1/2H2O4S

Synonyms

Armol
Elon (developer)
Genol
Graphol
Metatyl
Methyl-p-aminophenol sulfate
Metol
Phenol, p-(methylamino)-, sulfate (2:1) (salt)
Photol
Pictol
Planetol
p-Methylaminophenolsulfate
Rhodol
Verol

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /human 1%/48HCODEDG 11,256,1984

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium167 µg/plate (-enzymatic activation step)ENMUDM 9(Suppl 9),1,1987

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published lethal dose: 50 mg/kgKODAK* 21MAY1971
oral/mouse lethal dose (50 percent kill): 565 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Kidney, Ureter, and Bladder: Other changes in urine composition
NTIS** OTS0570966
oral/rat lowest published lethal dose: 200 mg/kgKODAK* 21MAY1971
skin/guinea pig lethal dose (50 percent kill): >1 gm/kgKODAK* 21MAY1971
unreported route/guinea pig lethal dose (50 percent kill): 1585 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea
GISAAA 49(9),87,1984
unreported route/mouse lethal dose (50 percent kill): 769 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea
GISAAA 49(9),87,1984
unreported route/rat lethal dose (50 percent kill): 705 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea
GISAAA 49(9),87,1984

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 9350 mg/kg/11D- continuousEndocrine: Changes in spleen weight

Blood: Changes in spleen
NTIS** OTS0570966
oral/rat lowest published toxic dose: 6600 mg/kg/94D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Endocrine: Changes in spleen weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0570966
unreported route/rat lowest published toxic dose: 4300 mg/kg/61D- intermittentBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
GISAAA 49(9),87,1984

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 81914; Number of Industries 37; Total Number of Facilities 6348; Number of Occupations 34; Total Number of Employees Exposed 43146; Total Number of Female Employees Exposed 24720
National Occupational Hazard Survey 1974Hazard Code 81914; Number of Industries 85; Total Number of Facilities 9601; Number of Occupations 47; Total Number of Employees Exposed 40485

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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