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Phenol, 4,4' - isopropylidenedi -

RTECS #: SL6300000

CAS #: 80-05-7


UPDATE: May 2009 MW: 228.31 MF: C15H16O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 2,2 - (4,4' - Dihydroxydiphenyl) propane
  2. 2,2 - Bis (4 - hydroxyphenyl) propane
  3. 2,2 - Bis (p - hydroxyphenyl) propane
  4. 2,2 - Bis - 4' - hydroxyfenylpropan (Czech)
  5. 2,2 - Di (4 - hydroxyphenyl) propane
  6. 2,2 - Di (4 - phenylol) propane
  7. 4,4' - Bisphenol A
  8. 4,4' - Dihydroxy - 2,2 - diphenylpropane
  9. 4,4' - Dihydroxydiphenyl - 2,2 - propane
  10. 4,4' - Dihydroxydiphenyldimethylmethane
  11. 4,4' - Dihydroxydiphenylpropane
  12. 4,4' - Isopropylidendiphenol
  13. 4,4' - Isopropylidendiphenol dust
  14. 4,4' - Isopropylidenebisphenol
  15. Bis (4 - hydroxyphenyl) dimethylmethane
  16. Bis (4 - hydroxyphenyl) propane
  17. Bisferol A (Czech)
  1. Bisphenol
  2. Bisphenol A
  3. Bisphenol A (OSHA)
  4. DIAN
  5. Dimethyl bis (p - hydroxyphenyl) methane
  6. Dimethylmethylene - p,p' - diphenol
  7. Diphenylolpropane
  8. NCI - C50635
  9. Phenol, 4,4' - dimethylmethylenedi -
  10. Propane, 2,2 - bis (p - hydroxyphenyl) -
  11. Ucar bisphenol A
  12. beta - Di - p - hydroxyphenylpropane
  13. p,p' - Dihydroxydiphenyldimethylmethane
  14. p,p' - Dihydroxydiphenylpropane
  15. p,p' - Isopropylidenebisphenol
  16. p,p' - Isopropylidenediphenol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
250 g/24 hour severe 85JCAE -,238,1986
skin
rabbit
250 mg open irritation test mild UCDS** 7/14/1965
skin
rabbit
500 mg/24 hour mild 85JCAE -,238,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 399 mol/L MUREAV 608,28,2006
cytogenetic analysis hamster 399 mol/L MUREAV 608,28,2006
cytogenetic analysis hamster ovary 0.5 mmol/L/3 hour MUREAV 649,114,2008
cytogenetic analysis hamster lung 8.4 mg/L/20 hour MUREAV 651,56,2008
cytogenetic analysis human lymphocyte 10 mg/L/22 hour MUREAV 651,46,2008
cytogenetic analysis mouse ovary 3 nmol/L/12 day MUREAV 651,71,2008
cytogenetic analysis mouse ovary 10 mg/L/16 hour MUREAV 651,82,2008
DNA adduct intraperitoneal
rat
200 mg/kg EMMUEG 26,60,1995
DNA adduct oral
rat
800 mg/kg/4 day- continuous EMMUEG 26,60,1995
DNA damage hamster ovary 0.7 mmol/L/1 hour MUREAV 649,114,2008
DNA damage human Ascites tumor 25 mg/L/2 hour FCTOD7 42,1323,2004
DNA damage mouse other cell types 100 mg/L/3 hour (-enzymatic activation step) MUREAV 541,9,2003
DNA damage oral
mouse
100 mg/kg TOXID9 44,456,2005
DNA damage rat liver 200 mol/L MUREAV 368,59,1996
DNA inhibition hamster ovary 400 mol/L MUREAV 400,169,1998
mutation in microorganisms Salmonella typhimurium 0.1 g/plate/24 hour (+/-enzymatic activation step) TCMUD8 22,425,2002
micronucleus test hamster lung 200 mol/L MUREAV 390,21,1997
micronucleus test human lymphocyte 12.3 mg/L/22 hour MUREAV 651,56,2008
sister chromatid exchange hamster ovary 0.4 mmol/L/3 hour MUREAV 649,114,2008


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 1,275 mg/kg (1-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system SWEHDO 7(Suppl 4),66,1981
intraperitoneal
rat
lowest published toxic dose: 1,275 mg/kg (1-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) APTOD9 19,A23,1980
intraperitoneal
rat
lowest published toxic dose: 1,875 mg/kg (1-15 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)
APTOD9 19,A23,1980
intraperitoneal
rat
lowest published toxic dose: 1,275 mg/kg (1-15 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system
SWEHDO 7(Suppl 4),66,1981
intraperitoneal
rat
lowest published toxic dose: 1,875 mg/kg (1-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Gastrointestinal system
SWEHDO 7(Suppl 4),66,1981
oral
mouse
lowest published toxic dose: 12,500 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
NTIS** PB85-205102
oral
mouse
lowest published toxic dose: 7,500 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) NTIS** PB85-205102
oral
mouse
lowest published toxic dose: 12,500 mg/kg (6-15 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina NTIS** PB85-205102
oral
mouse
lowest published toxic dose: 16,800 ng/kg (11-17 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects
AMZOAF 40,429,2000
oral
mouse
lowest published toxic dose: 14,000 ng/kg (11-17 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TIHEEC 14,239,1998
oral
mouse
lowest published toxic dose: 12,500 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
FAATDF 8,571,1987
oral
mouse
lowest published toxic dose: 1.75 gm/kg (multigenerations) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) NTIS** #PB86103207
oral
mouse
lowest published toxic dose: 153 gm/kg (multigenerations) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) NTIS** #PB86103207
oral
mouse
lowest published toxic dose: 171.5 gm/kg (98 day male) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) NTIS** #PB86103207
oral
mouse
lowest published toxic dose: 437 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system
NTIS** #PB86103207
oral
mouse
lowest published toxic dose: 50 g/kg (14-18 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on newborn: Behavioral
EVHPAZ 110(Suppl 3),415,2002
oral
mouse
lowest published toxic dose: 14 g/kg (11-17 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Behavioral
EVHPAZ 111,175,2003
oral
mouse
lowest published toxic dose: 560 mg/kg (8 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
LIFSAK 72,1159,2003
oral
mouse
lowest published toxic dose: 640 mg/kg (0 day pregnant-10 day after birth) Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow) TXAPA9 197,233,2004
oral
mouse
lowest published toxic dose: 10,500 mg/kg (21 day prior to copulation/21 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
TOXID9 66,372,2002
oral
rat
lowest published toxic dose: 10 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS** PB85-205110
oral
rat
lowest published toxic dose: 15 gm/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) NTIS** PB85-205110
oral
rat
lowest published toxic dose: 6,400 g/kg (13-22 day pregnant/1-6 day after birth) Reproductive: Effects on newborn: Behavioral PBBHAU 64,687,1999
oral
rat
lowest published toxic dose: 20 gm/kg (1-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects to embryo or fetus
LIFSAK 69,2611,2001
oral
rat
lowest published toxic dose: 0.2 g/kg (multigenerations) Reproductive: Specific developmental abnormalities: Respiratory system

Reproductive: Effects on newborn: Physical
REPTED 15,505,2001
oral
rat
lowest published toxic dose: 0.2 g/kg (multigenerations) Reproductive: Effects on newborn: Behavioral REPTED 15,505,2001
oral
rat
lowest published toxic dose: 2 g/kg (multigenerations) Reproductive: Effects on newborn: Physical REPTED 15,505,2001
oral
rat
lowest published toxic dose: 20 g/kg (multigenerations) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
REPTED 15,505,2001
oral
rat
lowest published toxic dose: 0.2 g/kg (multigenerations) Reproductive: Specific developmental abnormalities: Urogenital system REPTED 15,505,2001
oral
rat
lowest published toxic dose: 200 g/kg (multigenerations) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system REPTED 15,505,2001
oral
rat
lowest published toxic dose: 2 g/kg (multigenerations) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system
REPTED 15,505,2001
oral
rat
lowest published toxic dose: 20 g/kg (multigenerations) Reproductive: Specific developmental abnormalities: Central nervous system REPTED 15,505,2001
oral
rat
lowest published toxic dose: 2,120 g/kg (10 day prior to copulation-21 day after birth) Reproductive: Effects on newborn: Behavioral EVHPAZ 110(Suppl 3),403,2002
oral
rat
lowest published toxic dose: 8,000 g/kg (1-14 day pregnant/6 day after birth) Reproductive: Effects on newborn: Behavioral EVHPAZ 110(Suppl 3),403,2002
oral
rat
lowest published toxic dose: 1,760 g/kg (0-22 day pregnant/21 day after birth) Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Delayed effects
EVHPAZ 110(Suppl 3),409,2002
oral
rat
lowest published toxic dose: 3.8 mg/kg (6-22 day pregnant/21 day after birth) Nutritional and Gross Metabolic: Other changes EVHPAZ 109,675,2001
oral
rat
lowest published toxic dose: 45.6 mg/kg (6-22 day pregnant/21 day after birth) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Delayed effects

Nutritional and Gross Metabolic: Other changes
EVHPAZ 109,675,2001
oral
rat
lowest published toxic dose: 132 mg/kg (10-22 day pregnant/20 day after birth) Reproductive: Effects on newborn: Behavioral ETOPFR 14,99,2003
oral
rat
lowest published toxic dose: 800 mg/kg (10-22 day pregnant/7 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) ETOPFR 14,99,2003
oral
rat
lowest published toxic dose: 20 mg/kg (6 day pregnant -4 day after birth) Reproductive: Specific developmental abnormalities: Endocrine system TOXID9 44,202,2005
oral
rat
lowest published toxic dose: 1.6 mg/kg (6-21 day pregnant) Reproductive: Effects on newborn: Other postnatal measures or effects TOXID9 78,74,2004
oral
rat
lowest published toxic dose: 32 g/kg (6-21 day pregnant) Reproductive: Effects on newborn: Germ cell effects (in offspring) TOXID9 78,118,2004
oral
rat
lowest published toxic dose: 2,700 mg/kg (15-22 day pregnant/10 day after birth) Reproductive: Other effects on female

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
ARTODN 78,97,2004
oral
rat
lowest published toxic dose: 82.5 mg/kg (multigeneration) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TOXID9 60,297,2001
oral
rat
lowest published toxic dose: 825 mg/kg (multigeneration) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
TOXID9 60,297,2001
oral
rat
lowest published toxic dose: 460 mg/kg (1-23 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic HETOEA 25,369,2006
subcutaneous
mouse
lowest published toxic dose: 900 mg/kg (11-19 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system CGANE7 39,193,1999
subcutaneous
mouse
lowest published toxic dose: 90 mg/kg (10-18 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system REPTED 16,107,2002
subcutaneous
mouse
lowest published toxic dose: 14 g/kg (11-17 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical
REPTED 16,117,2002
subcutaneous
mouse
lowest published toxic dose: 140 g/kg (11-17 day pregnant) Reproductive: Effects on newborn: Physical REPTED 16,117,2002
subcutaneous
mouse
lowest published toxic dose: 540 mg/kg (1-4 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) REPTED 23,138,2007
subcutaneous
mouse
lowest published toxic dose: 1,620 mg/kg (1-4 day pregnant) Reproductive: Maternal effects: Parturition

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
REPTED 23,138,2007
subcutaneous
mouse
lowest published toxic dose: 11,014 mg/kg (1-4 day pregnant) Reproductive: Effects on fertility: Abortion REPTED 23,138,2007
subcutaneous
rat
lowest published toxic dose: 400 g/kg (8-23 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system BIREBV 65,1271,2001
subcutaneous
rat
lowest published toxic dose: 50 mg/kg (11-20 day pregnant) Reproductive: Other effects to embryo or fetus TOXID9 66,296,2002
subcutaneous
rat
lowest published toxic dose: 4,000 mg/kg (11-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TERPA* -,318,2005
unreported route
rat
lowest published toxic dose: 350 mg/kg (9-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) VCVGK* -,234,1994
unreported route
rat
lowest published toxic dose: 1.6 mg/kg (6-21 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Other postnatal measures or effects

Reproductive: Effects on newborn: Delayed effects
TOXID9 60,387,2001
unreported route
rat
lowest published toxic dose: 800 mg/kg (6-21 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system NSAPCC 369(Suppl 1),R112,2004
unreported route
rat
lowest published toxic dose: 4,000 mg/kg (11-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TERP3* -,262,2004


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 86,520 mg/kg/103 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Leukemia

Blood: Lymphoma including Hodgkin's disease
NTIS** PB82-184060
oral
rat
lowest published toxic dose: 43,260 mg/kg/103 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Leukemia

Reproductive: Tumorigenic effects: Testicular tumors
NTIS** PB82-184060
oral
rat
lowest published toxic dose: 36,050 mg/kg/103 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Leukemia
NTIS** PB82-184060


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 20 mg/m3/1 hour Behavioral: Headache

Gastrointestinal: Nausea or vomiting
VCVGK* -,234,1994
inhalation
mouse
lowest published toxic concentration: 500 mg/m3 Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
VCVGK* -,234,1994
inhalation
mouse
lethal concentration : >1,700 mg/m3/2 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
TPKVAL 2,50,1961
inhalation
mouse
lowest published toxic concentration: 500 mg/m3/2 hour Brain and Coverings: Changes in circulation

Behavioral: Somnolence (general depressed activity)

Cardiac: Cardiomyopathy including infarction
TPKVAL 2,50,1961
inhalation
mouse
lowest published toxic concentration: 500 mg/m3/2 hour Gastrointestinal: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney
TPKVAL 7,76,1965
intraperitoneal
mouse
lethal dose (50 percent kill): 150 mg/kg N/R ENTOX* -,314,2005
intraperitoneal
rat
lowest published toxic dose: 37.5 mg/kg Endocrine: Estrogenic

Reproductive: Maternal effects: Uterus, cervix, vagina

Biochemical: Metabolism (intermediary): Other
EVHPAZ 108,243,2000
intraperitoneal
rat
lowest published toxic dose: 150 mg/kg Endocrine: Estrogenic EVHPAZ 108,243,2000
intraperitoneal
rat
lethal dose (50 percent kill): 200 mg/kg N/R FCTOD7 41,1035,2003
ocular
rabbit
lowest published toxic dose: 100 pph Eye: Conjunctiva irritation

Eye: Corneal damage
TPKVAL 2,50,1961
ocular
rabbit
lowest published toxic dose: 100 pph Eye: Conjunctiva irritation TPKVAL 7,76,1965
oral
guinea pig
lethal dose (50 percent kill): 4 gm/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
GISAAA 33(7),25,1968
oral
guinea pig
lethal dose (50 percent kill): 4,000 mg/kg N/R ENTOX* -,314,2005
oral
human
lowest published toxic dose: 357.1 ng/kg Kidney, Ureter, and Bladder: Other changes in urine composition TXAPA9 197,190,2004
oral
mammal (species unspecified)
lethal dose (50 percent kill): 6,500 mg/kg N/R 34ZIAG -,135,1969
oral
mouse
lethal dose (50 percent kill): 2,400 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
GISAAA 33(7),25,1968
oral
mouse
lethal dose (50 percent kill): 2,500 mg/kg N/R VCVGK* -,234,1994
oral
mouse
lowest published toxic dose: 500 mg/kg Blood: Changes in bone marrow not included in above TOXID9 1,102,2001
oral
mouse
lowest published toxic dose: 1,000 mg/kg Behavioral: Sleep

Skin and Appendages: Other: Hair
TOXID9 1,102,2001
oral
mouse
lethal dose (20 percent kill): 1,500 mg/kg Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
TPKVAL 2,50,1961
oral
mouse
lethal dose (50 percent kill): 2,500 mg/kg Brain and Coverings: Changes in circulation

Liver: Fatty liver degeneration

Liver: Other changes
TPKVAL 2,50,1961
oral
mouse
lowest published toxic dose: 1,000 mg/kg Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TPKVAL 2,50,1961
oral
mouse
lethal dose (50 percent kill): 2,500 mg/kg Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes
TPKVAL 7,76,1965
oral
mouse
lowest published lethal dose: 1,000 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Gastrointestinal: Hypermotility, diarrhea
TPKVAL 7,76,1965
oral
rat
lethal dose (50 percent kill): 3,250 mg/kg N/R AIHAAP 28,301,1967
oral
rat
lethal dose (50 percent kill): 1,200 mg/kg Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) LIFSAK 69,2611,2001
oral
rat
lowest published toxic dose: 1,000 mg/kg Immunological Including Allergic: Decrease in cellular immune response LIFSAK 69,2611,2001
oral
rat
lethal dose (50 percent kill): 4,240 mg/kg Kidney, Ureter, and Bladder: Other changes in urine composition TPKVAL 4,43,1962
oral
rat
lowest published lethal dose: 2,500 mg/kg Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis
TPKVAL 2,50,1961
oral
rabbit
lethal dose (50 percent kill): 2,230 mg/kg N/R ENTOX* -,314,2005
subcutaneous
mouse
lowest published toxic dose: 100 g/kg Reproductive: Maternal effects: Uterus, cervix, vagina TOXID9 72,134,2003
subcutaneous
mouse
lowest published toxic dose: 100 mg/kg Related to Chronic Data: Changes in uterine weight

Biochemical: Metabolism (intermediary): Other proteins
TOLED5 144,257,2003
subcutaneous
mouse
lowest published lethal dose: 2,500 mg/kg Behavioral: Somnolence (general depressed activity)

Liver: Fatty liver degeneration

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TPKVAL 2,50,1961
subcutaneous
mouse
lethal dose : 2,500 mg/kg Behavioral: Somnolence (general depressed activity)

Cardiac: Other changes

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance
TPKVAL 2,50,1961
subcutaneous
rat
lowest published toxic dose: 5.9 mg/kg Endocrine: Estrogenic JAFCAU 18,1108,1970
subcutaneous
rat
lowest published toxic dose: 400 mg/kg Reproductive: Maternal effects: Uterus, cervix, vagina

Biochemical: Metabolism (intermediary): Other proteins
JTEHF8 70,171,2007
subcutaneous
rabbit
lethal dose (50 percent kill): 3,000 mg/kg N/R VCVGK* -,234,1994
skin
human
lowest published toxic concentration: 1 pph Skin: After topical application: Dermatitis, allergic AJCDE* 13,108,2002
skin
mammal (species unspecified)
lowest published toxic dose: 100 pph Skin: After topical application: Primary irritation TPKVAL 7,76,1965
skin
rabbit
lethal dose (50 percent kill): 3 mL/kg N/R AMIHBC 4,119,1951
unreported route
mouse
lowest published toxic dose: 100 mg/kg Blood: Changes in spleen

Immunological Including Allergic: Decrease in cellular immune response
TOXID9 60,29,2001


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 200 mg/m3/2 hour/31 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,234,1994
inhalation
mouse
lowest published toxic concentration: 200 mg/m3/2 hour/41 day- intermittent Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 2,50,1961
inhalation
mouse
lowest published toxic concentration: 200 mg/m3/41 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 2,50,1961
inhalation
rat
lowest published toxic concentration: 150 mg/m3/6 hour/13 week- intermittent Olfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 8,248,1988
inhalation
rat
lowest published toxic concentration: 47 mg/m3/4 hour/122 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,234,1994
inhalation
rat
lowest published toxic concentration: 47 mg/m3/2 hour/19 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Urine volume decreased or anuria

Endocrine: Changes in spleen weight
TPKVAL 4,43,1962
inhalation
rat
lowest published toxic concentration: 47 mg/m3/2 hour/122 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TPKVAL 4,43,1962
inhalation
rat
lowest published toxic concentration: 47 mg/m3/2 hour/22 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve TPKVAL 4,43,1962
inhalation
rat
lowest published toxic concentration: 47 mg/m3/2 hour/34 day- intermittent Blood: Other changes

Blood: Changes in erythrocyte (RBC) count
TPKVAL 4,43,1962
inhalation
rat
lowest published toxic concentration: 47 mg/m3/137 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TPKVAL 7,76,1965
intraperitoneal
rat
lowest published toxic dose: 320 mg/kg/4 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 41,1035,2003
oral
mammal (species unspecified)
lowest published toxic dose: 700 mg/kg/2 week- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) JJTHEC 65,933,2002
oral
mammal (species unspecified)
lowest published toxic dose: 3,500 mg/kg/2 week- continuous Liver: Changes in liver weight JJTHEC 65,933,2002
oral
mouse
lowest published toxic dose: 273 gm/kg/13 week- continuous Liver: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-215,1982
oral
mouse
lowest published toxic dose: 12,252 mg/kg/14 day- continuous Behavioral: Food intake (animal) NTIS** #PB86103207
oral
mouse
lowest published toxic dose: 257,250 mg/kg/21 week- intermittent Liver: Changes in liver weight NTIS** #PB86103207
oral
mouse
lowest published toxic dose: 257,250 mg/kg/21 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** #PB86103207
oral
mouse
lowest published toxic dose: 257,250 mg/kg/21 week- continuous Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) NTIS** #PB89169254
oral
mouse
lowest published toxic dose: 18.3 gm/kg/61 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Related to Chronic Data: Changes in testicular weight
FCTOD7 41,1035,2003
oral
mouse
lowest published toxic dose: 1,500 mg/kg/3 day- intermittent Related to Chronic Data: Changes in uterine weight TOXID9 60,297,2001
oral
mouse
lowest published toxic dose: 6,300 mg/kg/3 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
TOXID9 66,372,2002
oral
mouse
lowest published toxic dose: 10,500 mg/kg/6 week- continuous Reproductive: Maternal effects: Parturition

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TOXID9 66,372,2002
oral
mouse
lowest published toxic dose: 4.9 mg/kg/7 week- intermittent Reproductive: Maternal effects: Oogenesis MUREAV 651,64,2008
oral
rat
lowest published toxic dose: 42 gm/kg/8 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain ARZNAD 9,9,1959
oral
rat
lowest published toxic dose: 5,460 mg/kg/13 week- continuous Gastrointestinal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-215,1982
oral
rat
lowest published toxic dose: 31,500 mg/kg/9 week- intermittent Kidney, Ureter, and Bladder: Urine volume increased

Liver: Other changes

Blood: Other hemolysis with or without anemia
GISAAA 33(7),25,1968
oral
rat
lowest published toxic dose: 455 mg/kg/26 week- intermittent Behavioral: Alteration of classical conditioning

Liver: Liver function tests impaired

Blood: Other changes
GISAAA 33(7),25,1968
oral
rat
lowest published toxic dose: 300 mg/kg/3 day- intermittent Reproductive: Maternal effects: Menstrual cycle changes or disorders TOSCF2 54,154,2000
oral
rat
lowest published toxic dose: 4.2 gm/kg/14 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain LIFSAK 69,2611,2001
oral
rat
lowest published toxic dose: 7 mg/kg/7 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain LIFSAK 69,2611,2001
oral
rat
lowest published toxic dose: 1.2 gm/kg/4 day- intermittent Behavioral: Food intake (animal) LIFSAK 69,2611,2001
oral
rat
lowest published toxic dose: 20 gm/kg/20 day- intermittent Gastrointestinal: Other changes LIFSAK 69,2611,2001
oral
rat
lowest published toxic dose: 2,500 mg/kg/25 day- intermittent Reproductive: Maternal effects: Menstrual cycle changes or disorders TOSCF2 54,154,2000
oral
rat
lowest published toxic dose: 10.25 gm/kg/22 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain ARTODN 75,42,2001
oral
rat
lowest published toxic dose: 20.5 gm/kg/44 day- continuous Liver: Changes in liver weight ARTODN 75,42,2001
oral
rat
lowest published toxic dose: 10.34 gm/kg/44 day- continuous Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Other effects on male
ARTODN 75,42,2001
oral
rat
lowest published toxic dose: 41.8 gm/kg/44 day- continuous Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Related to Chronic Data: Changes in prostate weight
ARTODN 75,42,2001
oral
rat
lowest published toxic dose: 600 mg/kg/3 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina

Related to Chronic Data: Changes in uterine weight
CRTOEC 14,149,2001
oral
rat
lowest published toxic dose: 480 mg/kg/3 day- intermittent Endocrine: Estrogenic

Related to Chronic Data: Changes in uterine weight
EVHPAZ 108,1147,2000
oral
rat
lowest published toxic dose: 16,800 g/kg/12 week- intermittent Cardiac: Changes in heart weight REPTED 15,505,2001
oral
rat
lowest published toxic dose: 1.4 g/kg/1 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain REPTED 15,505,2001
oral
rat
lowest published toxic dose: 1,420 g/kg/71 day- intermittent Endocrine: Change in LH

Endocrine: Evidence of thyroid hypofunction
REPTED 15,505,2001
oral
rat
lowest published toxic dose: 10,000 mg/kg/10 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,234,1994
oral
rat
lowest published toxic dose: 5,040 mg/kg/6 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOXID9 72,84,2003
oral
rat
lowest published toxic dose: 6 g/kg/30 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXCYAC 188,117,2003
oral
rat
lowest published toxic dose: 200 mg/kg/4 day- intermittent Related to Chronic Data: Changes in uterine weight REPTED 17,421,2003
oral
rat
lowest published toxic dose: 400 mg/kg/4 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina REPTED 17,421,2003
oral
rat
lowest published toxic dose: 3,000 mg/kg/30 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
TOLED5 143,261,2003
oral
rat
lowest published toxic dose: 1,320 mg/kg/33 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain ETOPFR 14,99,2003
oral
rat
lowest published toxic dose: 13,200 mg/kg/33 day- intermittent Endocrine: Changes in thymus weight ETOPFR 14,99,2003
oral
rat
lowest published toxic dose: 31,080 g/kg/12 week- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina TXCYAC 205,103,2004
oral
rat
lowest published toxic dose: 2,700 mg/kg/18 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain ARTODN 78,97,2004
oral
rat
lowest published toxic dose: 16,800 mg/kg/28 day- intermittent Cardiac: Changes in heart weight

Endocrine: Differential effect of sex or castration on observed toxicity

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
ARTODN 76,65,2002
oral
rat
lowest published toxic dose: 7,000 mg/kg/1 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field

Endocrine: Differential effect of sex or castration on observed toxicity
ARTODN 76,65,2002
oral
rat
lowest published toxic dose: 3,500 g/kg/14 day- intermittent Behavioral: Alteration of classical conditioning TOXID9 1,113,2001
oral
rat
lowest published toxic dose: 15 mg/kg/3 day- intermittent Related to Chronic Data: Changes in uterine weight TOXID9 60,296,2001
oral
rat
lowest published toxic dose: 6,000 mg/kg/12 day- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in prostate weight
TOXID9 60,297,2001
oral
rat
lowest published toxic dose: 1,400 g/kg/14 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TOXID9 60,384,2001
oral
rat
lowest published toxic dose: 2,772 g/kg/12 week- intermittent Biochemical: Metabolism (intermediary): Lipids including transport TXCYAC 213,13,2005
oral
rat
lowest published toxic dose: 600 mg/kg/3 day- intermittent Endocrine: Other changes ARTODN 80,839,2006
oral
rat
lowest published toxic dose: 6,000 mg/kg/6 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TPKVAL 2,50,1961
oral
rat
lowest published toxic dose: 9,000 mg/kg/9 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 2,50,1961
oral
rat
lowest published toxic dose: 320 g/kg/8 day- intermittent Brain and Coverings: Other degenerative changes NETEEC 29,108,2007
oral
rat
lowest published toxic dose: 612 mg/kg/17 day- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Change in motor activity (specific assay)

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites
TOLED5 173,66,2007
oral
rat
lowest published toxic dose: 21 mg/kg/7 day- intermittent Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands NSAPCC 369(Suppl 1),R116,2004
oral
rat
lowest published toxic dose: 1,400 g/kg/14 day- intermittent Behavioral: Alteration of classical conditioning

Endocrine: Differential effect of sex or castration on observed toxicity
JTEHF8 66,2077,2003
oral
rat
lowest published toxic dose: 525 mg/kg/45 day- intermittent Brain and Coverings: Other degenerative changes TXCYAC 249,35,2008
oral
rabbit
lowest published toxic dose: 31,500 mg/kg/9 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in erythrocyte (RBC) count

Biochemical: Metabolism (intermediary): Lipids including transport
GISAAA 33(7),25,1968
oral
rabbit
lowest published toxic dose: 4,550 mg/kg/26 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Endocrine: Other changes
GISAAA 33(7),25,1968
subcutaneous
mouse
lowest published toxic dose: 0.3 mg/kg/3 day- continuous Endocrine: Estrogenic EVHPAZ 109,55,2001
subcutaneous
mouse
lowest published toxic dose: 300 mg/kg/3 day- continuous Endocrine: Estrogenic

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in uterine weight
EVHPAZ 109,55,2001
subcutaneous
mouse
lowest published toxic dose: 25 mg/kg/5 day- intermittent Endocrine: Changes in spleen weight

Immunological Including Allergic: Decrease in cellular immune response
TOLED5 136,217,2003
subcutaneous
rat
lowest published toxic dose: 0.1 mg/kg/11 day- continuous Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy) JSTBBK 60,153,1997
subcutaneous
rat
lowest published toxic dose: 273 mg/kg/15 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain CMSHAF 42,917,2001
subcutaneous
rat
lowest published toxic dose: 1.1 mg/kg/11 day- continuous Endocrine: Estrogenic

Skin and Appendages: Other: Breast

Tumorigenic: Cells (cultured) transformed
JSBBEZ 60,153,1997
subcutaneous
rat
lowest published toxic dose: 2,400 mg/kg/3 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in uterine weight
CRTOEC 14,149,2001
subcutaneous
rat
lowest published toxic dose: 30 mg/kg/3 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina CRTOEC 14,149,2001
subcutaneous
rat
lowest published toxic dose: 24 mg/kg/3 day- intermittent Endocrine: Estrogenic

Related to Chronic Data: Changes in uterine weight
EVHPAZ 108,1147,2000
subcutaneous
rat
lowest published toxic dose: 150 mg/kg/3 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina

Related to Chronic Data: Changes in uterine weight
JTSCDR 26,111,2001
subcutaneous
rat
lowest published toxic dose: 1,800 mg/kg/3 day- continuous Related to Chronic Data: Changes in uterine weight FCTOD7 41,1517,2003
subcutaneous
rat
lowest published toxic dose: 3,200 mg/kg/4 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 41,1035,2003
subcutaneous
rat
lowest published toxic dose: 1,000 mg/kg/10 day- intermittent Reproductive: Maternal effects: Menstrual cycle changes or disorders

Reproductive: Effects on newborn: Physical
REPTED 17,283,2003
subcutaneous
rat
lowest published toxic dose: 1,000 mg/kg/10 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina REPTED 17,283,2003
subcutaneous
rat
lowest published toxic dose: 4,000 mg/kg/10 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in ovarian weight

Related to Chronic Data: Changes in uterine weight
REPTED 17,283,2003
subcutaneous
rat
lowest published toxic dose: 60 mg/kg/3 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases CMSHAF 50,1167,2003
subcutaneous
rat
lowest published toxic dose: 300 mg/kg/3 day- intermittent Related to Chronic Data: Changes in uterine weight TXCYAC 207,215,2005
subcutaneous
rat
lowest published toxic dose: 873 mg/kg/9 day- intermittent Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) REPTED 22,20,2006
subcutaneous
rat
lowest published toxic dose: 18 g/kg/9 day- intermittent Endocrine: Estrogenic

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
REPTED 22,20,2006
subcutaneous
rat
: 0.4 mg/kg/2 day- intermittent Brain and Coverings: Other degenerative changes

Endocrine: Differential effect of sex or castration on observed toxicity
NETEEC 28,111,2006
subcutaneous
rat
lowest published toxic dose: 20,000 g/kg/2 day- intermittent Brain and Coverings: Other degenerative changes NRTXDN 28,1,2007
subcutaneous
rat
lowest published toxic dose: 500 g/kg/5 day- intermittent Endocrine: Changes in pituitary weight

Reproductive: Effects on newborn: Physical
JTPAE7 18,203,2005
subcutaneous
rat
lowest published toxic dose: 50 g/kg/5 day- intermittent Endocrine: Changes in pituitary weight JTPAE7 18,203,2005
subcutaneous
rat
lowest published toxic dose: 5,000 g/kg/5 day- intermittent Related to Chronic Data: Changes in prostate weight JTPAE7 18,203,2005
subcutaneous
rat
lowest published toxic dose: 30 g/kg/5 day- intermittent Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases

Related to Chronic Data: Changes in prostate weight
CNREA8 66,5624,2006
skin
rabbit
lowest published toxic dose: 10 pph/2 day- intermittent Skin: After topical application: Primary irritation TPKVAL 2,50,1961


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
FAATDF 13,747,1989
TOXICOLOGY REVIEW
FCTOD7 40,905,2002
TOXICOLOGY REVIEW
TOLED5 127,225,2002
TOXICOLOGY REVIEW
TOLED5 131,75,2002
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
TOLED5 140-141,37,2003
TOXICOLOGY REVIEW
MUTAEX 14,5,1999
TOXICOLOGY REVIEW
EMMUEG 43,36,2004
TOXICOLOGY REVIEW
REPTED 20,441,2005
TOXICOLOGY REVIEW
REPTED 22,164,2006
TOXICOLOGY REVIEW
MUREAV 613,68,2006
TOXICOLOGY REVIEW
ENTOX* -,314,2005
TOXICOLOGY REVIEW
ENTOX* -,258,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
MUREAV 651,1,2008
TOXICOLOGY REVIEW
JTEHD6 7,1,2004
TOXICOLOGY REVIEW
REPTED 25,192,2008
TOXICOLOGY REVIEW
REPTED 23,337,2007
TOXICOLOGY REVIEW
REPTED 23,374,2007
TOXICOLOGY REVIEW
REPTED 23,297,2007
TOXICOLOGY REVIEW
MUTAEX 19,423,2004
TOXICOLOGY REVIEW
JTPAE7 17,69,2004
TOXICOLOGY REVIEW
MUREAV 672,10,2009
TOXICOLOGY REVIEW
MUREAV 672,17,2009
TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 0.5 ppm (2.8 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Exposure Limit - GERMANY MAK 5 mg/m3 (inhalable, photosensitizer), 2005
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3 (respirable dust), 2003
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 10 mg/m3 (total dust), 2003
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 5 mg/m3;
KZG- week 5 mg/m3, DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 12845;
Number of Industries 82;
Total Number of Facilities 5,427;
Number of Occupations 74;
Total Number of Employees Exposed 71,597
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T0995;
Number of Industries 2;
Total Number of Facilities 6;
Number of Occupations 2;
Total Number of Employees Exposed 2,180;
Total Number of Female Employees Exposed 49
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 12845;
Number of Industries 70;
Total Number of Facilities 5,987;
Number of Occupations 78;
Total Number of Employees Exposed 92,138;
Total Number of Female Employees Exposed 15,144


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in preparation of epoxy resins and polycarbonate resins
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);equivocal evidence:mouse,rat
NTP Carcinogenesis Bioassay (feed);inadequate studies:mouse,rat NTPTR* NTP-TR-215,1982


REFERENCES:

CODEN
REFERENCE

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AJCDE* American Journal of Contact Dermatitis: Official Journal of the American Contact Dermatitis Society (Philadelphia, PA : W.B. Saunders, Harcourt Brace Jovanovich) V.1-14 1990-2003.
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
AMZOAF American Zoologist. (American Soc. of Zoologists, Box 2739, California Lutheran College, Thousand Oaks, CA 91360) V.1- 1961-
APTOD9 Abstracts of Papers, Society of Toxicology. Annual Meetings. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CGANE7 Congenital Anomalies. (Nippon Senten Ijo Gakkai, 377-2 Ono-higashi, Osakasayama, Osaka-Fu 589 Japan) V.27- 1987-
CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRTOEC Chemical Research in Toxicology. (American Chemical Soc., Distribution Office Dept. 223, POB 57/36, West End Station, Washington, DC 20037) V.1- 1988-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ETOPFR Environmental Toxicology and Pharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Feb.1996-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
HTOPA*
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
JJTHEC Japanese Journal of Toxicology and Environmental Health. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) V.38- 1992-
JSBBEZ Journal of Steroid Biochemistry and Molecular Biology. (Pergamon Press, c/o Elsevier Science, POB 945, New York, NY 10159) V.37- 1990-
JSTBBK Journal of Steroid Biochemistry. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 0BW, UK) V.1- 1969-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTEHF8 Journal of Toxicology and Environmental Health, Part A. (Taylor & Francis, 47 Runway Rd., Suite G, Levittown, PA 19057) V.53- 1998-
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987-
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
NSAPCC Naunyn-Schmiedeberg's Archives of Pharmacology. (Springer Verlag, Heidelberger, Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.272- 1972-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PBBHAU Pharmacology, Biochemistry and Behavior. (ANKHO International Inc., P.O. Box 426, Fayetteville, NY 13066) V.1- 1973-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
SWEHDO Scandinavian Journal of Work, Environment and Health. (Haartmaninkatu 1, SF-00290 Helsinki, 29, Finland) V.1- 1975-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TERP3*
TERPA*
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used in preparation of epoxy resins and polycarbonate resins

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Hormone
   Primary Irritant

Click Here for Additional Information about RTECS

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