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Registry of Toxic Effects of Chemical Substances (RTECS)

Phenol, 3,5-dichloro-

RTECS #

SK8820000

CAS #

591-35-5

Updated

December 2012

Molecular Weight

163.00

Molecular Formula

C6H4Cl2O

Synonyms

3,5-Dichlorophenol

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
specific locus testother cell types/human40.5 mg/L/3H (+enzymatic activation step)MUTAEX 24,35,2009
specific locus testother cell types/human81 mg/L/3H (-enzymatic activation step)MUTAEX 24,35,2009

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 2400 mg/kg (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
TJADAB 51,198,1995
oral/rat 2400 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TJADAB 51,198,1995
oral/rat 2400 mg/kg (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetal death
TJADAB 51,198,1995

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/mouse lethal dose (50 percent kill): 2389 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation
TOLED5 29,39,1985
oral/mouse lethal dose (50 percent kill): 2389 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold
TOLED5 29,39,1985

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intramuscular/rat lowest published toxic dose: 2400 mg/kg/10D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainTJADAB 51,198,1995

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-SWEDENtime-weighted average 0.5 mg/m3;short term exposure limit 1.5 mg/m3, Skin, JUN2005

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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