Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Phenol, 2,5-dichloro-

RTECS #

SK8600000

CAS #

583-78-8

Updated

December 2012

Molecular Weight

163.00

Molecular Formula

C6H4Cl2O

Synonyms

2,5-Dichlorophenol

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
sister chromatid exchangeintraperitoneal/mouse210 mg/kgJACTDZ 2(2),249,1983

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): >185000 mg/m3/4HLung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
HPV198 -,-,2001
oral/mouse lethal dose (50 percent kill): 946 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation
TOLED5 29,39,1985
oral/mouse lethal dose (50 percent kill): 946 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold
TOLED5 29,39,1985
oral/mouse lethal dose (50 percent kill): 946 mg/kgHPV198 -,-,2001
oral/rat lethal dose (50 percent kill): 580 mg/kgNTIS** PB85-143766
oral/rat lethal dose (50 percent kill): 2475 mg/kgVascular: Regional or general arteriolar or venous dilation

Gastrointestinal: Other changes
HPV198 -,-,2001
skin/rabbit lethal dose (50 percent kill): >8000 mg/kgNutritional and Gross Metabolic: Weight loss or decreased weight gainHPV198 -,-,2001

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 100 mg/m3/4W- intermittentLiver: Other changesHPV198 -,-,2001
inhalation/rat lowest published toxic concentration: 300 mg/m3/4W- intermittentLung, Thorax, or Respiration: Dyspnea

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV198 -,-,2001
skin/rabbit lowest published toxic dose: 15 mg/kg/21D- intermittentLiver: Changes in liver weight

Skin: After topical application: Primary irritation
HPV198 -,-,2001
skin/rabbit lowest published toxic dose: 150 mg/kg/21D- intermittentLiver: Changes in liver weight

Skin: After topical application: Primary irritation

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV198 -,-,2001

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-SWEDENtime-weighted average 0.5 mg/m3;short term exposure limit 1.5 mg/m3, Skin, JUN2005

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
TOP