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Registry of Toxic Effects of Chemical Substances (RTECS)

Phenol, 2,4-dichloro-

RTECS #

SK8575000

CAS #

120-83-2

Updated

July 2013

Molecular Weight

163.00

Molecular Formula

C6H4Cl2O

Synonyms

2,4-DCP
2,4-Dichlorohydroxybenzene
2,4-Dichlorophenol
NCI-C55345
RCRA waste number U081

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 500 µL/24H severeNTIS** OTS0534822

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster1400 µmol/LMUREAV 400,169,1998
Cytogenetic Analysisintraperitoneal/mouse180 mg/kgMUREAV 494,1,2001
DNA Damageliver/rat200 µmol/LEMMUEG 24,181,1994
DNA Damageliver/human31.6 µmol/l/48HMUREAV 696,21,2010
DNA Damageliver/human10 µmol/l/48HMUREAV 696,21,2010
DNA inhibitionovary/hamster1200 µmol/LMUREAV 400,169,1998
micronucleus testovary/hamster316 µmol/L/3H (+enzymatic activation step)MUREAV 724,7,2011
micronucleus testlung/hamster8.5 mg/L/3H (+enzymatic activation step)MUREAV 742,11,2012
micronucleus testovary/hamster23 mg/L/3H (+enzymatic activation step)MUREAV 742,11,2012
micronucleus testlymphocyte/human187 mg/L/3H (+enzymatic activation step)MUREAV 742,11,2012
morphological transformfibroblast/mouse20 mg/L/21D (-enzymatic activation step)EMMUEG 37,231,2001
mutation in mammalian somatic cellslymphocyte/mouse30 mg/LNTPTR* NTP-TR-353,1989
mutation in microorganisms/Salmonella typhimurium333 µg/plate (-enzymatic activation step)NTPTR* NTP-TR-353,1989
sex chromosome loss and nondisjunctionlung/hamster500 µmol/LMUREAV 182,135,1987
sister chromatid exchangeovary/hamster3100 µg/LNTPTR* NTP-TR-353,1989
specific locus testother cell types/human81 mg/L (+enzymatic activation step)MUREAV 695,87,2010
specific locus testother cell types/human81 mg/L/3H (+enzymatic activation step)MUTAEX 24,35,2009
specific locus testother cell types/human81 mg/L/48H (-enzymatic activation step)MUTAEX 24,35,2009
specific locus testother cell types/human162 mg/L/3H (-enzymatic activation step)MUTAEX 24,35,2009
sperm morphologyintraperitoneal/mouse180 mg/kgMUREAV 494,1,2001

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 20 mg/kg (1-20D pregnant)Reproductive: Other developmental abnormalitiesGISAAA 41(11),102,1976
oral/rat 7500 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TOXID9 4,167,1984
oral/rat 7500 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemFAATDF 13,635,1989
oral/rat 22 mg/kg (1-22D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities
VCVGK* -,247,1994
oral/rat 1650 mg/kg (1-22D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemVCVGK* -,247,1994
oral/rat 22 mg/kg (1-22D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects to embryo or fetus
GISAAA 40,102,1975
oral/rat 3 mg/kg (multigenerations)Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Other postnatal measures or effects
JTEHD6 14,723,1984
oral/rat 7500 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Other effects to embryo or fetus
FAATDF 13,635,1989
subcutaneous/mouse 666 mg/kg (6-14D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
NTIS** PB223-160

Tumorigenic Data and References

Route/OrganismDoseEffectReference
skin/mouse lowest published toxic dose: 16 gm/kg/39W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors
CNREA8 19,413,1959

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, erythrocytes Inhibitor Concentration Low: 250 mg/L/1HIn Vitro Toxicity Studies: Hemolysis in vitro

In Vitro Toxicity Studies: Other assays

Biochemical: Metabolism (intermediary): Lipids including transport
FCTOD7 49,2202,2011
In Vitro/Human, melanoma Inhibitor Concentration Low: 250 mg/L/1HBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: CatalasesFCTOD7 50,2123,2012
In Vitro/Non-mammalian species, fibroblast Inhibitor Concentration (50 percent kill): 0.81 mmol/L/24HIn Vitro Toxicity Studies: Cell countingTIVIEQ 7,537,1993
In Vitro/Rat, lung Inhibitor Concentration (10 percent kill): 0.023 gm/L/24HIn Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)TIVIEQ 7,111,1993
In Vitro/Rat, lung Inhibitor Concentration (50 percent kill): 0.3 gm/L/24HIn Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)TIVIEQ 7,111,1993
In Vitro/Rat, lung Inhibitor Concentration (75 percent kill): 1.4 gm/L/24HIn Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)TIVIEQ 7,111,1993
intraperitoneal/mouse lethal dose (50 percent kill): 153 mg/kgJMCMAR 18,868,1975
intraperitoneal/rat lethal dose (50 percent kill): 430 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Nutritional and Gross Metabolic: Body temperature increase
BJPCAL 13,20,1958
intraperitoneal/rat lethal dose (50 percent kill): 430 mg/kgVCVGK* -,245,1994
oral/guinea pig lowest published lethal dose: 2 gm/kgABANAE 7,321,1959/1960
oral/mammal (species unspecified) lethal dose (50 percent kill): 464 mg/kgGISAAA 45(10),16,1980
oral/mouse lethal dose (50 percent kill): 1276 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold
TOLED5 29,39,1985
oral/mouse lethal dose (50 percent kill): 1276 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
FAATDF 5,478,1985
oral/mouse lethal dose (50 percent kill): 580 mg/kgBFUUA* 31,1,1989
oral/rat lethal dose (50 percent kill): 380 mg/kgVCVGK* -,245,1994
oral/rat lethal dose (50 percent kill): 47 mg/kgBehavioral: Food intake (animal)

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Other changes
NTIS** OTS0534822
skin/mammal (species unspecified) lethal dose (50 percent kill): 790 mg/kgGISAAA 45(10),16,1980
skin/rabbit lowest published lethal dose: 3160 mg/kgBehavioral: Food intake (animal)

Lung, Thorax, or Respiration: Pulmonary emboli

Liver: Other changes
NTIS** OTS0534822
subcutaneous/rat lethal dose (50 percent kill): 580 mg/kgBFUUA* 31,1,1989

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 100 mg/m3/4H/152D- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Liver: Liver function tests impaired
VCVGK* -,247,1994
intramuscular/mouse lowest published toxic dose: 40320 mg/kg/24W- continuousLiver: Other changes

Liver: Changes in liver weight
TOIZAG 19,356,1972
intramuscular/rat lowest published toxic dose: 7500 mg/kg/10D- intermittentLung, Thorax, or Respiration: Other changes

Skin and Appendages: Other: Hair

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FAATDF 13,635,1989
intramuscular/rat lowest published toxic dose: 2000 mg/kg/10D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainFAATDF 13,635,1989
intraperitoneal/guinea pig lowest published toxic dose: 480 mg/kg/2W- intermittentLiver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
INHEAO 34,415,1996
oral/guinea pig lowest published toxic dose: 106.5 mg/kg/213D- intermittentLiver: Changes in liver weight

Endocrine: Changes in spleen weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
VCVGK* -,247,1994
oral/mouse lowest published toxic dose: 591220 mg/kg/103W- continuousBlood: Lymphoma including Hodgkin's disease

Tumorigenic: Active as anti-cancer agent
NTIS** PB90-106170/AS
oral/mouse lowest published toxic dose: 31770 mg/kg/90D- continuousBehavioral: Fluid intake

Blood: Changes in cell count (unspecified)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
FAATDF 5,478,1985
oral/mouse lowest published toxic dose: 437 gm/kg/13W- continuousKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-353,1989
oral/mouse lowest published toxic dose: 67200 mg/kg/14D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-353,1989
oral/rat lowest published toxic dose: 91 gm/kg/13W- continuousBlood: Changes in bone marrow not included in aboveNTPTR* NTP-TR-353,1989
oral/rat lowest published toxic dose: 7500 mg/kg/10D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
BFUUA* 31,1,1989
oral/rat lowest published toxic dose: 151410 mg/kg/103W- continuousBlood: Leukemia

Tumorigenic: Active as anti-cancer agent
NTIS** PB90-106170/AS

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Human Limited EvidenceIMEMDT 41,319,1986
International Agency for Research on Cancer (IARC)Cancer Review:Animal No EvidenceIMEMDT 71,769,1999
TOXICOLOGY REVIEWSTEVA8 2,305,1974
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWEMMUEG 43,36,2004
TOXICOLOGY REVIEWENTOX* -,567,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWADMOL* 1,85,2006
TOXICOLOGY REVIEWMUREAV 653,23,2008
TOXICOLOGY REVIEWMUREAV 654,114,2008
TOXICOLOGY REVIEWITODC* -,327,2004
TOXICOLOGY REVIEWMUREAV 672,10,2009
TOXICOLOGY REVIEWMUREAV 672,17,2009
TOXICOLOGY REVIEWMUREAV 653,99,2008
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.3 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.5 mg/m3;short term exposure limit 1.5 mg/m3, Skin, JUN2005

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X4154; Number of Industries 1; Total Number of Facilities 6; Number of Occupations 1; Total Number of Employees Exposed 63; Total Number of Female Employees Exposed 23

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/110757/AS)
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9261
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);no evidence:mouse,rat
On EPA IRIS database
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