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Phenol, 2,6 - di - tert - butyl -

RTECS #: SK8265000

CAS #: 128-39-2


UPDATE: February 2004 MW: 206.36 MF: C14H22O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. 2,6 - Bis (tert - butyl) phenol
  2. 2,6 - Di - tert - butylphenol
  1. Ethanox 701


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intravenous
mouse
lethal dose (50 percent kill): 60 mg/kg N/R VCVGK* -,211,1994
intravenous
rabbit
lowest published lethal dose: 10 mg/kg N/R VCVGK* -,211,1994
oral
mouse
lethal dose (50 percent kill): 800 mg/kg N/R NTIS** OTS0526583
oral
rat
lethal dose (50 percent kill): 1,320 mg/kg N/R VCVGK* -,211,1994
skin
guinea pig
lethal dose (50 percent kill): >10 gm/kg N/R NTIS** OTS0526583
skin
rabbit
lethal dose (50 percent kill): >10 gm/kg N/R NTIS** OTS0526583


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 12,480 ng/kg/12 day- continuous Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
BJCAAI 45,935,1982
oral
rat
lowest published toxic dose: 19,708 mg/kg/3 week- continuous Gastrointestinal: Hypermotility, diarrhea

Blood: Change in clotting factors

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 46,811,1978
oral
rat
lowest published toxic dose: 2,459.3 mg/kg/7 day- continuous Blood: Change in clotting factors

Nutritional and Gross Metabolic: Conditioned vitamin deficiency

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,211,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M4376;
Number of Industries 9;
Total Number of Facilities 196;
Number of Occupations 12;
Total Number of Employees Exposed 2,192
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M4376;
Number of Industries 175;
Total Number of Facilities 13,899;
Number of Occupations 97;
Total Number of Employees Exposed 365,623;
Total Number of Female Employees Exposed 72,928


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as intermediate for manufacture of pesticides, dyestuffs, antioxidants, pharmaceuticals
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as intermediate for manufacture of pesticides, dyestuffs, antioxidants, pharmaceuticals

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