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Registry of Toxic Effects of Chemical Substances (RTECS)

Phenol, 2,6-di-tert-butyl-

RTECS #

SK8265000

CAS #

128-39-2

Updated

August 2009

Molecular Weight

206.36

Molecular Formula

C14H22O

Synonyms

2,6-Bis(tert-butyl)phenol
2,6-Di-tert-butylphenol
Ethanox 701

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rat 0.5 mL moderateHPV110 -,-,2001

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 30000 mg/kg (14D pre-4D after birth)Reproductive: Other effects on female

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
HPV110 -,-,2001

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intravenous/mouse lethal dose (50 percent kill): 60 mg/kgVCVGK* -,211,1994
intravenous/rabbit lowest published lethal dose: 10 mg/kgVCVGK* -,211,1994
oral/mouse lethal dose (50 percent kill): 800 mg/kgNTIS** OTS0526583
oral/rat lethal dose (50 percent kill): 1320 mg/kgVCVGK* -,211,1994
oral/rat lethal dose (50 percent kill): >5000 mg/kgBehavioral: Ataxia

Liver: Other changes

Blood: Hemorrhage
HPV110 -,-,2001
skin/guinea pig lethal dose (50 percent kill): >10 gm/kgNTIS** OTS0526583
skin/rabbit lethal dose (50 percent kill): >10 gm/kgNTIS** OTS0526583
skin/rat lowest published lethal dose: 32000 mg/kgHPV110 -,-,2001

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 12480 ng/kg/12D- continuousLiver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
BJCAAI 45,935,1982
oral/rat lowest published toxic dose: 2459.3 mg/kg/7D- continuousBlood: Change in clotting factors

Nutritional and Gross Metabolic: Conditioned vitamin deficiency

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,211,1994
oral/rat lowest published toxic dose: 2800 mg/kg/28D- intermittentLiver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Gastrointestinal: Other changes
HPV110 -,-,2001
oral/rat lowest published toxic dose: 16800 mg/kg/28D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Gastrointestinal: Other changes
HPV110 -,-,2001
oral/rat lowest published toxic dose: 19708 mg/kg/3W- continuousGastrointestinal: Hypermotility, diarrhea

Blood: Change in clotting factors

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 46,811,1978

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M4376; Number of Industries 175; Total Number of Facilities 13899; Number of Occupations 97; Total Number of Employees Exposed 365623; Total Number of Female Employees Exposed 72928
National Occupational Hazard Survey 1974Hazard Code M4376; Number of Industries 9; Total Number of Facilities 196; Number of Occupations 12; Total Number of Employees Exposed 2192

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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