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Registry of Toxic Effects of Chemical Substances (RTECS)

Phenol, p-chloro-

RTECS #

SK2800000

CAS #

106-48-9

Updated

December 2012

Molecular Weight

128.56

Molecular Formula

C6H5ClO

Synonyms

4-Chlorophenol
4-Hydroxychlorobenzene
Applied 3-78
p-Chlorfenol (Czech)
p-Chlorophenic acid
p-Chlorophenol
Phenol, 4-chloro- (9CI)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 250 µg/24H severe85JCAE -,523,1986
skin /rabbit 2 mg/24H severe85JCAE -,523,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisoral/rat81 mg/kgZKMAAX 25,339,1985
Cytogenetic Analysisembryo/hamster30 µmol/L/3HMUREAV 603,111,2006
mutation in microorganisms/Salmonella typhimurium200 µg/plate (+enzymatic activation step)PCBPBS 10,174,1979
mutation in microorganisms/Salmonella typhimurium10 µg/plate (-enzymatic activation step)TECSDY 14,143,1987

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/mouse 760 µg/m3/24H (17W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
GISAAA 57(7-8),9,1992
oral/rat 3500 mg/kg (70D prior to copulation)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)VCVGK* -,244,1994
oral/rat 550 mg/kg (1-22D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)VCVGK* -,244,1994

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Non-mammalian species, fibroblast Inhibitor Concentration (50 percent kill): 1.29 mmol/L/24HIn Vitro Toxicity Studies: Cell countingTIVIEQ 7,537,1993
inhalation/human lowest published toxic concentration: 10 gm/m3/8HBehavioral: Excitement

Behavioral: Irritability

Nutritional and Gross Metabolic: Other changes
GISAAA 29(10),37,1964
inhalation/mouse Lowest published lethal concentration: 3200 mg/m3/2HBrain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
GISAAA 57(7-8),9,1992
inhalation/rat lethal concentration (50 percent kill): 11 mg/m3GISAAA 29(10),37,1964
intraperitoneal/mouse lethal dose (50 percent kill): 332 mg/kgJMCMAR 18,868,1975
intraperitoneal/rat lethal dose (50 percent kill): 281 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Nutritional and Gross Metabolic: Body temperature increase
BJPCAL 13,20,1958
intraperitoneal/rat lethal dose (50 percent kill): 281 mg/kgBrain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,245,1994
oral/mammal (species unspecified) lethal dose (50 percent kill): 500 mg/kgGISAAA 45(10),16,1980
oral/mouse lethal dose (50 percent kill): 1373 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold
TOLED5 29,39,1985
oral/mouse lethal dose (50 percent kill): 605 mg/kgBrain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,245,1994
oral/mouse lethal dose (50 percent kill): 367 mg/kgBehavioral: Excitement

Behavioral: Coma
ZKMAAX 25,339,1985
oral/rat lethal dose (50 percent kill): 261 mg/kgBrain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,245,1994
oral/rat lethal dose (50 percent kill): 670 mg/kgFEPRA7 2,76,1943
skin/mammal (species unspecified) lethal dose (50 percent kill): 1 gm/kgGISAAA 45(10),16,1980
skin/rat lethal dose (50 percent kill): 1000 mg/kgBrain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,245,1994
skin/rat lethal dose (50 percent kill): 1500 mg/kgBehavioral: Muscle contraction or spasticity

Skin: After topical application: Corrosive
GISAAA 29(10),37,1964
subcutaneous/rat lethal dose (50 percent kill): 1030 mg/kgFEPRA7 2,76,1943
subcutaneous/rat lethal dose (50 percent kill): 1030 mg/kgBrain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,245,1994
unreported route/mouse lethal dose (50 percent kill): 605 mg/kgAutonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement
GISAAA 54(1),68,1989
unreported route/rat lethal dose (50 percent kill): 625 mg/kgAutonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement
GISAAA 54(1),68,1989

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 24 µg/m3/24H/17W- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
GISAAA 57(7-8),9,1992
inhalation/rat lowest published toxic concentration: 2 mg/m3/6H/17W- intermittentNutritional and Gross Metabolic: Other changesGISAAA 29(10),37,1964
oral/mammal (species unspecified) lowest published toxic dose: 182 mg/kg/26W- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,244,1994

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 mg/m3, skin, MAY2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.5 mg/m3, skin, NOV2011
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-POLANDMAC(time-weighted average) 1 mg/m3, short term exposure limit 3 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.5 mg/m3;short term exposure limit 1.5 mg/m3, Skin, JUN2005

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84588; Number of Industries 6; Total Number of Facilities 200; Number of Occupations 5; Total Number of Employees Exposed 2796; Total Number of Female Employees Exposed 1865
National Occupational Hazard Survey 1974Hazard Code 84588; Number of Industries 4; Total Number of Facilities 185; Number of Occupations 19; Total Number of Employees Exposed 4844

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: o-Chlorophenol, 2014
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