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Registry of Toxic Effects of Chemical Substances (RTECS)

Phenol, o-chloro-

RTECS #

SK2625000

CAS #

95-57-8

Updated

December 2012

Molecular Weight

128.56

Molecular Formula

C6H5ClO

Synonyms

2-Chlorophenol
2-Hydroxychlorobenzene
o-Chlorophenic acid
o-Chlorophenol
o-Chlorphenol (German)
Phenol, 2-chloro-
RCRA waste number U048

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
sex chromosome loss and nondisjunctionlung/hamster800 µmol/LMUREAV 182,135,1987

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 4550 mg/kg (70D prior to copulation/1-21D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Stillbirth
EVHPAZ 46,137,1982

Tumorigenic Data and References

Route/OrganismDoseEffectReference
skin/mouse lowest published toxic dose: 4800 mg/kg/12W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
CNREA8 19,413,1959

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lowest published lethal concentration: 3100 mg/m3/6HBehavioral: Excitement

Lung, Thorax, or Respiration: Respiratory stimulation

Skin and Appendages: Other: Hair
NTIS** OTS0534816
inhalation/rat lethal concentration (50 percent kill): 210 mg/m3TOVEFN (3),41,2006
intraperitoneal/mouse lethal dose (50 percent kill): 235 mg/kgJMCMAR 18,868,1975
intraperitoneal/rat lethal dose (50 percent kill): 230 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Nutritional and Gross Metabolic: Body temperature increase
BJPCAL 13,20,1958
intraperitoneal/rat lethal dose (50 percent kill): 230 mg/kgBrain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,245,1994
intravenous/rabbit lowest published lethal dose: 120 mg/kgHBTXAC 5,112,1959
oral/mammal (species unspecified) lethal dose (50 percent kill): 440 mg/kgBehavioral: Muscle weakness

Behavioral: Muscle contraction or spasticity

Skin and Appendages: Other: Sweating
TIVSAI 33,258,1969
oral/mouse lethal dose (50 percent kill): 345 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold
TOLED5 29,39,1985
oral/mouse lethal dose (50 percent kill): 345 mg/kgBrain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,245,1994
oral/mouse lethal dose (50 percent kill): 710 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Behavioral: Ataxia
TOVEFN (3),41,2006
oral/mouse lethal dose (50 percent kill): 345 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation
TOLED5 29,39,1985
oral/rat lethal dose (50 percent kill): 40 mg/kgLung, Thorax, or Respiration: Pulmonary emboli

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0534844
oral/rat lethal dose (50 percent kill): 660 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Behavioral: Ataxia
TOVEFN (3),41,2006
oral/rat lethal dose (50 percent kill): 670 mg/kgBrain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,245,1994
skin/rabbit lowest published lethal dose: 1580 mg/kgBehavioral: Food intake (animal)

Lung, Thorax, or Respiration: Pulmonary emboli

Liver: Other changes
NTIS** OTS0534831
subcutaneous/frog lowest published lethal dose: 400 mg/kgHBTXAC 5,112,1959
subcutaneous/guinea pig lowest published lethal dose: 800 mg/kgHBAMAK 4,1361,1935
subcutaneous/rabbit lowest published lethal dose: 950 mg/kgHBAMAK 4,1361,1935
subcutaneous/rat lethal dose (50 percent kill): 950 mg/kgFEPRA7 2,76,1943
subcutaneous/rat lethal dose (50 percent kill): 950 mg/kgBrain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,245,1994

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 2450 mg/kg/14D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTIS** PB85-101772

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWADMOL* 1,85,2006
TOXICOLOGY REVIEWMUREAV 741,32,2012

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 mg/m3, skin, MAY2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.5 mg/m3, skin, NOV2011
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.3 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.5 mg/m3;short term exposure limit 1.5 mg/m3, Skin, JUN2005

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84363; Number of Industries 2; Total Number of Facilities 158; Number of Occupations 4; Total Number of Employees Exposed 974; Total Number of Female Employees Exposed 323
National Occupational Hazard Survey 1974Hazard Code 84363; Number of Industries 1; Total Number of Facilities 23; Number of Occupations 1; Total Number of Employees Exposed 495

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9019
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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