Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Phenol, m-chloro-

RTECS #

SK2450000

CAS #

108-43-0

Updated

December 2012

Molecular Weight

128.56

Molecular Formula

C6H5ClO

Synonyms

3-Chlorophenol
3-Hydroxychlorobenzene
m-Chlorophenic acid
m-Chlorophenol
Phenol, 3-chloro-

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium10 µg/plate (+/-enzymatic activation step)TECSDY 14,143,1987

Tumorigenic Data and References

Route/OrganismDoseEffectReference
skin/mouse lowest published toxic dose: 6000 mg/kg/15W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
CNREA8 19,413,1959

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Non-mammalian species, fibroblast Inhibitor Concentration (50 percent kill): 2.72 mmol/L/24HIn Vitro Toxicity Studies: Cell countingTIVIEQ 7,537,1993
intraperitoneal/rat lethal dose (50 percent kill): 355 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Nutritional and Gross Metabolic: Body temperature increase
BJPCAL 13,20,1958
intraperitoneal/rat lethal dose (50 percent kill): 355 mg/kgBrain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,245,1994
oral/mouse lethal dose (50 percent kill): 521 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation
TOLED5 29,39,1985
oral/mouse lethal dose (50 percent kill): 521 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold
TOLED5 29,39,1985
oral/rat lethal dose (50 percent kill): 520 mg/kgBrain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,245,1994
oral/rat lethal dose (50 percent kill): 570 mg/kgFEPRA7 2,76,1943
subcutaneous/rat lethal dose (50 percent kill): 1390 mg/kgFEPRA7 2,76,1943
subcutaneous/rat lethal dose (50 percent kill): 1390 mg/kgBrain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,245,1994

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 mg/m3, skin, MAY2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.5 mg/m3, skin, NOV2011
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-SWEDENtime-weighted average 0.5 mg/m3;short term exposure limit 1.5 mg/m3, Skin, JUN2005

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X4138; Number of Industries 1; Total Number of Facilities 17; Number of Occupations 1; Total Number of Employees Exposed 919; Total Number of Female Employees Exposed 306

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
TOP