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Registry of Toxic Effects of Chemical Substances (RTECS)

Phenol, 2-sec-butyl-4,6-dinitro-

RTECS #

SJ9800000

CAS #

88-85-7

Updated

October 2010

Molecular Weight

240.24

Molecular Formula

C10H12N2O5

Synonyms

2-(1-Methylpropyl)-4,6-dinitrophenol
2,4-Dinitro-6-sec-butylphenol
2-sec-Butyl-4,6-dinitrophenol
4,6-Dinitro-2-(1-methyl-n-propyl)phenol
4,6-Dinitro-2-sec.butylfenol (Czech)
4,6-Dinitro-2-sec-butylphenol
4,6-Dinitro-o-sec-butylphenol
6-(1-Methyl-propyl)-2,4-dinitrofenol (Dutch)
6-(1-Metil-propil)-2,4-dinitro-fenolo (Italian)
Aatox
Basanite
Blaartox
BNP 30
Butaphen
Butaphene
Caldon
Chemox P.E.
DBNF
Desicoil
Dibutox
Dibutox 20CE
Dinoseb
Dinosebe (French)
DN 289
DNBP
DNOSBP
DNSBP
Dow General Weed Killer
Dow Selective Weed Killer
Dytop
ENT 1,122
Hel-Fire
Hivertox
Kiloseb
Ladob
Laseb
Nitropone C
Phenol, 2-(1-methylpropyl)-4,6-dinitro- (9CI)
Premerge
RCRA waste number P020
Sinox general
Sparic
Spurge
Subitex
Unicrop DNBP
Vertac Dinitro Weed Killer
Vertac General Weed Killer
Vertac Selective Weed Killer
WSX 8365

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 50 µg/24H severe85JCAE -,679,1986
eye /rabbit 0.1 mL severeHPV333 -,-,2003

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
gene conversion and mitotic recombination/Saccharomyes cerevisiae185 ppmMUREAV 21,83,1973

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 22500 µg/kg (10-12D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)FAATDF 11,381,1988
intraperitoneal/rat 27 mg/kg (10-12D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)JTEHD6 6,633,1980
intraperitoneal/rat 24 mg/kg (10-12D pregnant)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
FAATDF 11,381,1988
intraperitoneal/mouse 30 mg/kg (10-12D pregnant)Reproductive: Specific developmental abnormalities: Central nervous systemFCTXAV 11,31,1973
intraperitoneal/mouse 47400 µg/kg (10-12D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system
TJADAB 12,147,1975
intraperitoneal/mouse 37500 µg/kg (14-16D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
FCTXAV 11,31,1973
intraperitoneal/mouse 47400 µg/kg (10-12D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JTEHD6 1,107,1975
oral/rat 100 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
REPTED 29,292,2010
oral/rat 93.5 mg/kg (6-16D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)REPTED 29,292,2010
oral/rat 80 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemREPTED 29,292,2010
oral/rat 71.72 mg/kg (6-16D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemREPTED 29,292,2010
oral/mouse 288 mg/kg (8-16D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)FCTXAV 11,31,1973
oral/mouse 26 mg/kg (8D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemTCMUD8 5,3,1985
oral/mouse 100 mg/kg (7-8D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JJATDK 16,115,1996
oral/rat 1201 mg/kg (77D male)Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)AECTCV 11,475,1982
oral/rat 820 mg/kg (8W male/8W pre-22D pregnant)Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)
TXAPA9 45,235,1978
oral/rat 820 mg/kg (8W male/8W pre-22D pregnant)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TXAPA9 45,235,1978
oral/rat 100 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Eye, earTJADAB 33,19A,1986
oral/rat 78 mg/kg (20D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)AECTCV 11,475,1982
oral/rat 150 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TJADAB 33,19A,1986
subcutaneous/mouse 53100 µg/kg (14-16D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
FCTXAV 11,31,1973
subcutaneous/mouse 53100 µg/kg (10-12D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemFCTXAV 11,31,1973

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 764 mg/kg/78W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
NTIS** PB223-159

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat Lowest published lethal concentration: 45 mg/m3/3H85GMAT -,61,1982
inhalation/rat Lowest published lethal concentration: 2190 mg/m3Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
HPV333 -,-,2003
intraperitoneal/mouse lethal dose (50 percent kill): 10 mg/kgBCPCA6 18,1389,1969
intraperitoneal/rat lowest published toxic dose: 7.2 mg/kgEndocrine: Other changesARTODN 65,15,1991
oral/chicken lethal dose (50 percent kill): 26 mg/kg85JFAN A159,1984
oral/duck lethal dose (50 percent kill): 9 mg/kgDOEAAH 35,25,1979
oral/guinea pig lethal dose (50 percent kill): 20 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation
TXAPA9 7,353,1965
oral/mouse lethal dose (50 percent kill): 16 mg/kg85GMAT -,61,1982
oral/rat lethal dose (50 percent kill): 25 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation
TXAPA9 7,353,1965
oral/rat lowest published lethal dose: 91 mg/kgBehavioral: AtaxiaHPV333 -,-,2003
oral/rat lowest published toxic dose: 17.5 mg/kgRelated to Chronic Data: Changes in prostate weightREPTED 6,491,1992
oral/wild bird lethal dose (50 percent kill): 7100 µg/kgTXAPA9 21,315,1972
skin/guinea pig lowest published lethal dose: 500 mg/kgJIHTAB 30,10,1948
skin/mouse lowest published lethal dose: 40 mg/kgTXAPA9 7,353,1965
skin/rabbit lethal dose (50 percent kill): 80 mg/kgPEMNDP 9,306,1991
skin/rabbit lethal dose (50 percent kill): 40 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Skin: After topical application: Primary irritation
HPV333 -,-,2003
skin/rat lethal dose (50 percent kill): 80 mg/kgWRPCA2 9,119,1970
subcutaneous/rat lethal dose (50 percent kill): 20368 µg/kgJPPMAB 4,1062,1952
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 60 mg/kg30ZDA9 -,98,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 72800 µg/kg/26W- intermittentEndocrine: Other changes

Blood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GNAMAP 17,41,1978
oral/rat lowest published toxic dose: 87.5 mg/kg/5D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)REPTED 6,491,1992
oral/rat lowest published toxic dose: 80 mg/kg/10D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainREPTED 29,292,2010
oral/rat lowest published toxic dose: 32 mg/kg/4D- intermittentBehavioral: Food intake (animal)REPTED 29,292,2010
oral/rat lowest published toxic dose: 50 mg/kg/10D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldREPTED 29,292,2010
oral/rat lowest published toxic dose: 71.72 mg/kg/11D- intermittentBehavioral: Food intake (animal)REPTED 29,292,2010

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWDTTIAF 80,485,1973
TOXICOLOGY REVIEWEVHPAZ 15,121,1976
TOXICOLOGY REVIEWENTOX* -,63,2005
TOXICOLOGY REVIEWREPTED 25,327,2007
TOXICOLOGY REVIEWREPTED 26,185,2008

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.05 mg/m3, Skin, JUN2003

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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