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Registry of Toxic Effects of Chemical Substances (RTECS)

Phenol, p-(tert-butyl)-

RTECS #

SJ8925000

CAS #

98-54-4

Updated

July 2013

Molecular Weight

150.24

Molecular Formula

C10H14O

Synonyms

1-Hydroxy-4-tert-butylbenzene
4-(1,1-Dimethylethyl)phenol
4-t-Butylphenol
4-tert-Butylphenol
Butylphen
Phenol, 4-(1,1-dimethylethyl)-
PTBP
p-terc.Butylfenol (Czech)
p-tert-Butylphenol
Ucar butylphenol 4-T
Ucar butylphenol 4-T flake

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 10 mg severeDCTODJ 11,43,1988
eye /rabbit 50 µg/24H severe85JCAE -,224,1986
skin /rabbit 500 mg/4H mildDCTODJ 11,43,1988
skin /rabbit 500 mg/24H mild85JCAE -,224,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislung/hamster10 mmol/L/6H (+enzymatic activation step)MUREAV 517,187,2002
specific locus testother cell types/mouse40 mg/L/24H (-enzymatic activation step)MUTAEX 14,23,1999

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/hamster lowest published toxic dose: 252 gm/kg/20W- continuousTumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors
CRNGDP 7,1285,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 0.84 mg/m3Endocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
VCVGK* -,203,1994
inhalation/rat Lowest published lethal concentration: 5600 mg/m3/4HLung, Thorax, or Respiration: Respiratory depression

Skin: After topical application: Primary irritation

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
DCTODJ 11,43,1988
intraperitoneal/mouse lethal dose (50 percent kill): 78 mg/kgJMCMAR 18,868,1975
intraperitoneal/rat lethal dose (50 percent kill): 225 mg/kgNTIS** OTS0573039
oral/mammal (species unspecified) lethal dose (50 percent kill): 1500 mg/kgGISAAA 45(10),16,1980
oral/mouse lethal dose (50 percent kill): 1030 mg/kgBehavioral: Tetany

Behavioral: Irritability
VCVGK* -,203,1994
oral/rat lethal dose (50 percent kill): 3250 µL/kgAIHAAP 30,470,1969
skin/mammal (species unspecified) lethal dose (50 percent kill): 1580 mg/kgGISAAA 45(10),16,1980
skin/rabbit lethal dose (50 percent kill): 2520 µL/kgAIHAAP 30,470,1969

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 67 mg/m3/6H/122D- intermittentBlood: Changes in other cell count (unspecified)VCVGK* -,203,1994

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWHTOPA* 1,501,2002

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,241,1998
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.08 ppm (0.5 mg/m3);KZW 0.4 ppm (2.5 mg/m3), skin, sen, 2007
Occupational Exposure Limit-DENMARKtime-weighted average 0.08 ppm (0.5 mg/m3), skin, MAY2011
Occupational Exposure Limit-GERMANYMAK 0.080 ppm (0.5 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.08 ppm (0.5 mg/m3), skin, NOV2011
Occupational Exposure Limit-RUSSIAtime-weighted average 0.4 mg/m3, short term exposure limit 1 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 0.08 ppm (0.5 mg/m3), KZG-week 0.16 ppm (1 mg/m3), sen, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.5 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 81915; Number of Industries 55; Total Number of Facilities 4673; Number of Occupations 64; Total Number of Employees Exposed 97601; Total Number of Female Employees Exposed 19779
National Occupational Hazard Survey 1974Hazard Code 81915; Number of Industries 42; Total Number of Facilities 3505; Number of Occupations 40; Total Number of Employees Exposed 29500

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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