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Phenol, p - (tert - butyl) -

RTECS #: SJ8925000

CAS #: 98-54-4


UPDATE: May 2009 MW: 150.24 MF: C10H14O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1 - Hydroxy - 4 - tert - butylbenzene
  2. 4 - (1,1 - Dimethylethyl) phenol
  3. 4 - t - Butylphenol
  4. 4 - tert - Butylphenol
  5. Butylphen
  6. PTBP
  1. Phenol, 4 - (1,1 - dimethylethyl) -
  2. Ucar butylphenol 4 - T
  3. Ucar butylphenol 4 - T flake
  4. p - terc.Butylfenol (Czech)
  5. p - tert - Butylphenol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
10 mg severe DCTODJ 11,43,1988
eye
rabbit
50 g/24 hour severe 85JCAE -,224,1986
skin
rabbit
500 mg/4 hour mild DCTODJ 11,43,1988
skin
rabbit
500 mg/24 hour mild 85JCAE -,224,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster lung 10 mmol/L/6 hour (+enzymatic activation step) MUREAV 517,187,2002
specific locus test mouse other cell types 40 mg/L/24 hour (-enzymatic activation step) MUTAEX 14,23,1999


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
hamster
lowest published toxic dose: 252 gm/kg/20 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors
CRNGDP 7,1285,1986


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 0.84 mg/m3 Endocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
VCVGK* -,203,1994
inhalation
rat
lowest published lethal concentration: 5,600 mg/m3/4 hour Lung, Thorax, or Respiration: Respiratory depression

Skin: After topical application: Primary irritation

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
DCTODJ 11,43,1988
intraperitoneal
mouse
lethal dose (50 percent kill): 78 mg/kg N/R JMCMAR 18,868,1975
intraperitoneal
rat
lethal dose (50 percent kill): 225 mg/kg N/R NTIS** OTS0573039
oral
mammal (species unspecified)
lethal dose (50 percent kill): 1,500 mg/kg N/R GISAAA 45(10),16,1980
oral
mouse
lethal dose (50 percent kill): 1,030 mg/kg Behavioral: Tetany

Behavioral: Irritability
VCVGK* -,203,1994
oral
rat
lethal dose (50 percent kill): 3,250 L/kg N/R AIHAAP 30,470,1969
skin
mammal (species unspecified)
lethal dose (50 percent kill): 1,580 mg/kg N/R GISAAA 45(10),16,1980
skin
rabbit
lethal dose (50 percent kill): 2,520 L/kg N/R AIHAAP 30,470,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 67 mg/m3/6 hour/122 day- intermittent Blood: Changes in other cell count (unspecified) VCVGK* -,203,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,241,1998
Occupational Exposure Limit - DENMARK time-weighted average 0.08 ppm (0.5 mg/m3), OCT 2002
Occupational Exposure Limit - GERMANY MAK 0.5 mg/m3 (0.08 mL/m3) (skin, sen), 2005
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.5 mg/m3, 2003
Occupational Exposure Limit - RUSSIA time-weighted average 0.4 mg/m3, short term exposure limit 1 mg/m3, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.08 ppm (0.5 mg/m3);
KZG- week 0.16 ppm (1.0 mg/m3), DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81915;
Number of Industries 42;
Total Number of Facilities 3,505;
Number of Occupations 40;
Total Number of Employees Exposed 29,500
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81915;
Number of Industries 55;
Total Number of Facilities 4,673;
Number of Occupations 64;
Total Number of Employees Exposed 97,601;
Total Number of Female Employees Exposed 19,779


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in motor oil additives, as soap antioxidant, intermediate to make varnish and lacquers
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HTOPA*
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used in motor oil additives, as soap antioxidant, intermediate to make varnish and lacquers

RTECS Compound Description:
   Tumorigen
   Mutagen
   Primary Irritant

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