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Registry of Toxic Effects of Chemical Substances (RTECS)

Phenol, o-(tert-butyl)-

RTECS #

SJ8921000

CAS #

88-18-6

Updated

August 2009

Molecular Weight

150.24

Molecular Formula

C10H14O

Synonyms

2-t-Butylphenol
Phenol, 2-(1,1-dimethylethyl)-

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 µL/4H severeNTIS** OTS0558757
skin /rabbit 500 µL/4H severeNTIS** OTS0558757

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 1070 mg/m3/4HNTIS** OTS0558707
intraperitoneal/mouse lethal dose (50 percent kill): 82 mg/kgJMCMAR 18,868,1975
oral/rat lethal dose (50 percent kill): 789 mg/kgBehavioral: Ataxia

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
HPV110 -,-,2001
oral/rat lethal dose (50 percent kill): 440 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression
NTIS** OTS0558707
skin/rabbit lethal dose (50 percent kill): 7450 mg/kgNTIS** OTS0558707
skin/rat lethal dose (50 percent kill): 705 mg/kgEye: Lacrimation

Behavioral: Coma

Nutritional and Gross Metabolic: Body temperature decrease
NTIS** OTS0558758
skin/rat lethal dose (50 percent kill): 705 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Hematuria

Blood: Changes in spleen
HPV110 -,-,2001

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 9086 ng/kg/12D- intermittentLiver: Other changes

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
BJCAAI 45,935,1982
oral/mouse lowest published toxic dose: 20520 mg/kg/38D- intermittentTumorigenic: Active as anti-cancer agentHPV110 -,-,2001

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X1072; Number of Industries 3; Total Number of Facilities 221; Number of Occupations 6; Total Number of Employees Exposed 8300; Total Number of Female Employees Exposed 239

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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