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Registry of Toxic Effects of Chemical Substances (RTECS)

Phenol, o-amino-

RTECS #

SJ4950000

CAS #

95-55-6

Updated

December 2010

Molecular Weight

109.14

Molecular Formula

C6H7NO

Synonyms

2-Amino-1-hydroxybenzene
2-Aminophenol
2-Hydroxyanaline
BASF ursol 3GA
Benzofur GG
C.I. 76520
C.I. Oxidation Base 17
Fouramine OP
Nako Yellow 3GA
o-Aminophenol
o-Hydroxyaniline
Paradone Olive Green B
Pelagol 3GA
Pelagol Grey GG
Questiomycin B
Zoba 3GA

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg mildFCTOD7 20,573,1982

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA inhibitionlung/hamster19 µmol/LCRTOEC 4,151,1991
DNA repair/Escherichia coli20 µg/wellMUREAV 133,161,1984
mutation in microorganisms/Salmonella typhimurium333 µg/plate (+enzymatic activation step)ENMUDM 5(Suppl 1),3,1983

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/hamster 150 mg/kg (8D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear
TXAPA9 63,264,1982
intraperitoneal/hamster 150 mg/kg (8D pregnant)Reproductive: Specific developmental abnormalities: Body wall

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXAPA9 63,264,1982

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 200 mg/kgNTIS** AD691-490
intraperitoneal/rat lowest published lethal dose: 300 mg/kgAIPTAK 131,151,1961
oral/mouse lethal dose (50 percent kill): 800 mg/kgBehavioral: Tremor

Lung, Thorax, or Respiration: Cyanosis
NTIS** OTS0555965
oral/quail lethal dose (50 percent kill): 316 mg/kgAECTCV 12,355,1983
oral/rat lethal dose (50 percent kill): 951 mg/kgBehavioral: Tremor

Lung, Thorax, or Respiration: Cyanosis
NTIS** OTS0555965
skin/guinea pig lethal dose (50 percent kill): >1 gm/kgNTIS** OTS0555965
subcutaneous/cat lowest published lethal dose: 37 mg/kgBehavioral: General anesthetic

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis
AEXPBL 72,241,1913
subcutaneous/rat lethal dose (50 percent kill): 37 mg/kgYKYUA6 32,1093,1981
unreported route/mouse lethal dose (50 percent kill): 675 mg/kgGISAAA 50(3),4,1985
unreported route/rat lethal dose (50 percent kill): 1406 mg/kgGISAAA 50(3),4,1985

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 7032 mg/kg/12D- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Normocytic anemia
NTIS** OTS0555965

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWIJTOFN 23,1,2004
TOXICOLOGY REVIEWTXAPA9 243,239,2010

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAtime-weighted average 1 mg/m3, short term exposure limit 3 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X1659; Number of Industries 1; Total Number of Facilities 1948; Number of Occupations 1; Total Number of Employees Exposed 19664; Total Number of Female Employees Exposed 14753

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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