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Phenol, o - amino -

RTECS #: SJ4950000

CAS #: 95-55-6


UPDATE: November 2007 MW: 109.14 MF: C6H7NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 2 - Amino - 1 - hydroxybenzene
  2. 2 - Aminophenol
  3. 2 - Hydroxyanaline
  4. BASF ursol 3GA
  5. Benzofur GG
  6. C.I. 76520
  7. C.I. Oxidation Base 17
  8. Fouramine OP
  1. Nako Yellow 3GA
  2. Paradone Olive Green B
  3. Pelagol 3GA
  4. Pelagol Grey GG
  5. Questiomycin B
  6. Zoba 3GA
  7. o - Aminophenol
  8. o - Hydroxyaniline


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 mg mild FCTOD7 20,573,1982


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA inhibition hamster lung 19 mol/L CRTOEC 4,151,1991
DNA repair Escherichia coli 20 g/well MUREAV 133,161,1984
mutation in microorganisms Salmonella typhimurium 333 g/plate (+enzymatic activation step) ENMUDM 5(Suppl 1),3,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
hamster
lowest published toxic dose: 150 mg/kg (8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear
TXAPA9 63,264,1982
intraperitoneal
hamster
lowest published toxic dose: 150 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Body wall

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXAPA9 63,264,1982


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 200 mg/kg N/R NTIS** AD691-490
intraperitoneal
rat
lowest published lethal dose: 300 mg/kg N/R AIPTAK 131,151,1961
oral
mouse
lethal dose (50 percent kill): 800 mg/kg Behavioral: Tremor

Lung, Thorax, or Respiration: Cyanosis
NTIS** OTS0555965
oral
quail
lethal dose (50 percent kill): 316 mg/kg N/R AECTCV 12,355,1983
oral
rat
lethal dose (50 percent kill): 951 mg/kg Behavioral: Tremor

Lung, Thorax, or Respiration: Cyanosis
NTIS** OTS0555965
subcutaneous
cat
lowest published lethal dose: 37 mg/kg Behavioral: General anesthetic

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis
AEXPBL 72,241,1913
subcutaneous
rat
lethal dose (50 percent kill): 37 mg/kg N/R YKYUA6 32,1093,1981
skin
guinea pig
lethal dose (50 percent kill): >1 gm/kg N/R NTIS** OTS0555965
unreported route
mouse
lethal dose (50 percent kill): 675 mg/kg N/R GISAAA 50(3),4,1985
unreported route
rat
lethal dose (50 percent kill): 1,406 mg/kg N/R GISAAA 50(3),4,1985


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 7,032 mg/kg/12 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Normocytic anemia
NTIS** OTS0555965


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
IJTOFN 23,1,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA time-weighted average 1 mg/m3, short term exposure limit 3 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1659;
Number of Industries 1;
Total Number of Facilities 1,948;
Number of Occupations 1;
Total Number of Employees Exposed 19,664;
Total Number of Female Employees Exposed 14,753


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in manufacture of azo and sulfur dyes and in dyeing furs and hair
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC.
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
CRTOEC Chemical Research in Toxicology. (American Chemical Soc., Distribution Office Dept. 223, POB 57/36, West End Station, Washington, DC 20037) V.1- 1988-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used in manufacture of azo and sulfur dyes and in dyeing furs and hair

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector
   Primary Irritant

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