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Registry of Toxic Effects of Chemical Substances (RTECS)

p-Phenetidine

RTECS #

SI6465500

CAS #

156-43-4

Updated

February 2006

Molecular Weight

137.20

Molecular Formula

C8H11NO

Synonyms

4-Aminoethoxybenzene
4-Aminophenetole
4-Ethoxyaniline
4-Ethoxybenzenamine
Aniline, p-ethoxy-
Benzenamine, 4-ethoxy- (9CI)
CP 5685
p-Aminofenetol (Czech)
p-Aminophenetole
p-Ethoxyaniline
p-Fenetidin (Czech)
Phenethidine
p-Phenetidin

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg moderateFCTOD7 20,563,1982
eye /rabbit 100 mg/4S rinse mildFCTOD7 20,563,1982
skin /rabbit 500 mg mildFCTOD7 20,563,1982

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA inhibitionlung/hamster160 µmol/LMUTAEX 3,51,1988
mutation in microorganisms/Salmonella typhimurium1 µmol/plate (-enzymatic activation step)CPBTAL 33,2877,1985

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lowest published lethal concentration: 487 mg/m3/4HEye: Lacrimation

Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes
NTIS** OTS0546240
intraperitoneal/mouse lethal dose (50 percent kill): 692 mg/kgJMCMAR 17,900,1974
oral/mouse lethal dose (50 percent kill): 530 mg/kgGTPZAB 25(8),50,1981
oral/rabbit lethal dose (50 percent kill): 7 gm/kgNYKZAU 52,215,1956
oral/rat lethal dose (50 percent kill): 540 mg/kgGISAAA 43(1),92,1978
skin/rabbit lethal dose (50 percent kill): 2353 mg/kgCardiac: Other changes

Lung, Thorax, or Respiration: Emphysema

Kidney, Ureter, and Bladder: Hematuria
NTIS** OTS0555214

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rabbit lowest published toxic dose: 45750 µg/kg/9W- intermittentBlood: Normocytic anemia

Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Other changes
GISAAA 43(1),92,1978
oral/rat lowest published toxic dose: 1120 mg/kg/28D- intermittentEndocrine: Changes in spleen weight

Blood: Changes in bone marrow not included in above

Blood: Changes in erythrocyte (RBC) count
ESKHA5 (109),42,1991
oral/rat lowest published toxic dose: 15250 µg/kg/9W- intermittentBlood: Normocytic anemia

Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Other changes
GISAAA 43(1),92,1978

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.2 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X4375; Number of Industries 1; Total Number of Facilities 6; Number of Occupations 1; Total Number of Employees Exposed 206; Total Number of Female Employees Exposed 23

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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