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p - Phenetidine

RTECS #: SI6465500

CAS #: 156-43-4


UPDATE: February 2006 MW: 137.20 MF: C8H11NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 4 - Aminoethoxybenzene
  2. 4 - Aminophenetole
  3. 4 - Ethoxyaniline
  4. 4 - Ethoxybenzenamine
  5. Aniline, p - ethoxy -
  6. Benzenamine, 4 - ethoxy - (9CI)
  7. CP 5685
  1. Phenethidine
  2. p - Aminofenetol (Czech)
  3. p - Aminophenetole
  4. p - Ethoxyaniline
  5. p - Fenetidin (Czech)
  6. p - Phenetidin


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 mg moderate FCTOD7 20,563,1982
eye
rabbit
100 mg/4S rinse mild FCTOD7 20,563,1982
skin
rabbit
500 mg mild FCTOD7 20,563,1982


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA inhibition hamster lung 160 µmol/L MUTAEX 3,51,1988
mutation in microorganisms Salmonella typhimurium 1 µmol/plate (-enzymatic activation step) CPBTAL 33,2877,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published lethal concentration: 487 mg/m3/4 hour Eye: Lacrimation

Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes
NTIS** OTS0546240
intraperitoneal
mouse
lethal dose (50 percent kill): 692 mg/kg N/R JMCMAR 17,900,1974
oral
mouse
lethal dose (50 percent kill): 530 mg/kg N/R GTPZAB 25(8),50,1981
oral
rat
lethal dose (50 percent kill): 540 mg/kg N/R GISAAA 43(1),92,1978
oral
rabbit
lethal dose (50 percent kill): 7 gm/kg N/R NYKZAU 52,215,1956
skin
rabbit
lethal dose (50 percent kill): 2,353 mg/kg Cardiac: Other changes

Lung, Thorax, or Respiration: Emphysema

Kidney, Ureter, and Bladder: Hematuria
NTIS** OTS0555214


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 1,120 mg/kg/28 day- intermittent Endocrine: Changes in spleen weight

Blood: Changes in bone marrow not included in above

Blood: Changes in erythrocyte (RBC) count
ESKHA5 (109),42,1991
oral
rat
lowest published toxic dose: 15,250 µg/kg/9 week- intermittent Blood: Normocytic anemia

Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Other changes
GISAAA 43(1),92,1978
oral
rabbit
lowest published toxic dose: 45,750 µg/kg/9 week- intermittent Blood: Normocytic anemia

Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Other changes
GISAAA 43(1),92,1978


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 0.2 mg/m3, Skin, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4375;
Number of Industries 1;
Total Number of Facilities 6;
Number of Occupations 1;
Total Number of Employees Exposed 206;
Total Number of Female Employees Exposed 23


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958-
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944-

RTECS Compound Description:
   Drug
   Mutagen
   Primary Irritant

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