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Phenethyl alcohol

RTECS #: SG7175000

CAS #: 60-12-8


UPDATE: February 2006 MW: 122.18 MF: C8H10O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 2 - Phenethyl alcohol
  2. 2 - Phenylethanol
  3. 2 - Phenylethyl alcohol
  4. Benzyl carbinol
  5. Ethanol, 2 - phenyl -
  6. Methanol, benzyl -
  7. PEA
  8. Phenethanol
  1. Phenylethyl alcohol
  2. beta - Fenethylalkohol (Czech)
  3. beta - Fenylethanol (Czech)
  4. beta - Hydroxyethylbenzene
  5. beta - Pea
  6. beta - Phenethyl alcohol
  7. beta - Phenylethanol
  8. beta - Phenylethyl alcohol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
12 gm/10 minute mild ARZNAD 9,349,1959
eye
rabbit
750 g/24 hour severe 85JCAE -,215,1986
skin
guinea pig
1,00% mild FCTXAV 13,903,1975
skin
guinea pig
100 mg/24 hour moderate CTOIDG 94(8),41,1979
skin
rabbit
100 mg/24 hour moderate CTOIDG 94(8),41,1979


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Saccharomyes cerevisiae 1,000 ppm (-enzymatic activation step) GENRA8 13,107,1969
other mutation test systems mouse Ascites tumor 8,360 mol/L BCPCA6 22,2511,1973


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 43 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
JTEHD6 12,235,1983
oral
rat
lowest published toxic dose: 430 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system
JTEHD6 12,235,1983
oral
rat
lowest published toxic dose: 43 mg/kg (6-15 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) VCVGK* -,135,1994
oral
rat
lowest published toxic dose: 430 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system
VCVGK* -,135,1994
skin
rat
lowest published toxic dose: 14 gm/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities
EPASR* 8EHQ-0186-0587
skin
rat
lowest published toxic dose: 4,300 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system EPASR* 8EHQ-0186-0587


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): >500 mg/m3 Behavioral: Somnolence (general depressed activity)

Blood: Normocytic anemia

Nutritional and Gross Metabolic: Body temperature decrease
GISAAA 52(10),83,1987
inhalation
rat
lethal concentration (50 percent kill): >500 mg/m3 N/R VCVGK* -,135,1984
inhalation
rat
lowest published toxic concentration: 120 mg/m3/4 hour Behavioral: Somnolence (general depressed activity)

Blood: Normocytic anemia

Nutritional and Gross Metabolic: Body temperature decrease
VCVGK* -,135,1984
intraperitoneal
guinea pig
lethal dose (50 percent kill): 200 mg/kg N/R 38MKAJ 2C,4642,1982
intraperitoneal
mouse
lowest published toxic dose: 200 mg/kg Behavioral: Antianxiety LIFSAK 72,91,2002
oral
guinea pig
lethal dose (50 percent kill): 2,540 mg/kg N/R VPITAR 33(5),48,1974
oral
guinea pig
lethal dose (50 percent kill): 400 mg/kg Brain and Coverings: Other degenerative changes VCVGK* -,135,1984
oral
mouse
lethal dose (50 percent kill): 2,540 mg/kg N/R VPITAR 33(5),48,1974
oral
mouse
lethal dose (50 percent kill): 800 mg/kg Brain and Coverings: Other degenerative changes VCVGK* -,135,1984
oral
rat
lethal dose (50 percent kill): 1,790 mg/kg Behavioral: Coma

Gastrointestinal: Gastritis
FCTXAV 2,327,1964
oral
rat
lethal dose (50 percent kill): 1,800 mg/kg Brain and Coverings: Other degenerative changes VCVGK* -,135,1984
oral
rabbit
lowest published lethal dose: 2 gm/kg N/R JEENAI 48,139,1955
subcutaneous
mouse
lowest published lethal dose: 1,640 mg/kg Behavioral: General anesthetic

Behavioral: Ataxia

Behavioral: Coma
JPETAB 14,211,1920
skin
mouse
lethal dose (30 percent kill): 100 pph N/R VCVGK* -,135,1984
skin
rabbit
lethal dose (50 percent kill): 790 L/kg N/R TXAPA9 28,313,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 6 gm/kg/30 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 50(2),70,1985
oral
rat
lowest published toxic dose: 6,052 mg/kg/17 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
VPITAR 33(5),48,1974
skin
rat
lowest published toxic dose: 90 mL/kg/90 day- intermittent Blood: Normocytic anemia

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,135,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
TOLED5 140-141,239,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, Skin, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80836;
Number of Industries 22;
Total Number of Facilities 873;
Number of Occupations 41;
Total Number of Employees Exposed 34,310
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80836;
Number of Industries 44;
Total Number of Facilities 10,505;
Number of Occupations 77;
Total Number of Employees Exposed 161,595;
Total Number of Female Employees Exposed 92,702


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in flavors and perfumery
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976-
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
GENRA8 Genetical Research. (Cambridge Univ. Press, 32 E. 57th St., New York, NY 10022) V.1- 1960-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JEENAI Journal of Economic Entomology. (Entomological Soc. of America, 4603 Calvert Rd., College Park, MD 20740) V.1- 1908-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.
VPITAR Voprosy Pitaniya. Problems of Nutrition. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1932-41; V.11- 1952-

Used in flavors and perfumery

NIOSH PROFILE (ALCOHOLS), SRI, 2/77

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Primary Irritant

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