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Registry of Toxic Effects of Chemical Substances (RTECS)

Phenethyl alcohol

RTECS #

SG7175000

CAS #

60-12-8

Updated

November 2009

Molecular Weight

122.18

Molecular Formula

C8H10O

Synonyms

2-Phenethyl alcohol
2-Phenylethanol
2-Phenylethyl alcohol
Benzyl carbinol
beta-Fenethylalkohol (Czech)
beta-Fenylethanol (Czech)
beta-Hydroxyethylbenzene
beta-Pea
beta-Phenethyl alcohol
beta-Phenylethanol
beta-Phenylethyl alcohol
Ethanol, 2-phenyl-
Methanol, benzyl-
PEA
Phenethanol
Phenylethyl alcohol

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 12 gm/10M mildARZNAD 9,349,1959
eye /rabbit 750 µg/24H severe85JCAE -,215,1986
skin /guinea pig 100% mildFCTXAV 13,903,1975
skin /guinea pig 100 mg/24H moderateCTOIDG 94(8),41,1979
skin /rabbit 100 mg/24H moderateCTOIDG 94(8),41,1979

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Saccharomyes cerevisiae1000 ppm (-enzymatic activation step)GENRA8 13,107,1969
other mutation test systemsAscites tumor/mouse8360 µmol/LBCPCA6 22,2511,1973

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 43 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
JTEHD6 12,235,1983
oral/rat 430 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system
JTEHD6 12,235,1983
oral/rat 43 mg/kg (6-15D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)VCVGK* -,135,1994
oral/rat 430 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system
VCVGK* -,135,1994
oral/rat 4300 mg/kg (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Musculoskeletal system
HPV133 -,-,2002
oral/rat 508 mg/kg (10D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)HPV133 -,-,2002
skin/rat 14000 mg/kg (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
HPV133 -,-,2002
skin/rat 700 mg/kg (6-15D pregnant)Reproductive: Other effects on femaleHPV133 -,-,2002
skin/rat 2800 mg/kg (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
HPV133 -,-,2002
skin/rat 14 gm/kg (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities
EPASR* 8EHQ-0186-0587
skin/rat 4300 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemEPASR* 8EHQ-0186-0587

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): >500 mg/m3Behavioral: Somnolence (general depressed activity)

Blood: Normocytic anemia

Nutritional and Gross Metabolic: Body temperature decrease
GISAAA 52(10),83,1987
inhalation/rat lethal concentration (50 percent kill): >500 mg/m3VCVGK* -,135,1984
inhalation/rat lowest published toxic concentration: 120 mg/m3/4HBehavioral: Somnolence (general depressed activity)

Blood: Normocytic anemia

Nutritional and Gross Metabolic: Body temperature decrease
VCVGK* -,135,1984
inhalation/rat lethal concentration (50 percent kill): >4630 mg/m3/4HHPV133 -,-,2002
intraperitoneal/guinea pig lethal dose (50 percent kill): 200 mg/kg38MKAJ 2C,4642,1982
intraperitoneal/mouse lowest published toxic dose: 200 mg/kgBehavioral: AntianxietyLIFSAK 72,91,2002
intraperitoneal/mouse lethal dose (50 percent kill): 200 mg/kgHPV133 -,-,2002
oral/guinea pig lethal dose (50 percent kill): 2540 mg/kgHPV133 -,-,2002
oral/guinea pig lethal dose (50 percent kill): 400 mg/kgBrain and Coverings: Other degenerative changesVCVGK* -,135,1984
oral/mouse lethal dose (50 percent kill): 2540 mg/kgHPV133 -,-,2002
oral/mouse lethal dose (50 percent kill): 800 mg/kgBrain and Coverings: Other degenerative changesVCVGK* -,135,1984
oral/rabbit lowest published lethal dose: 2 gm/kgJEENAI 48,139,1955
oral/rat lethal dose (50 percent kill): 1800 mg/kgBrain and Coverings: Other degenerative changesVCVGK* -,135,1984
oral/rat lethal dose (50 percent kill): 1790 mg/kgBehavioral: Coma

Gastrointestinal: Gastritis
HPV133 -,-,2002
oral/rat lethal dose (50 percent kill): 1500 mg/kgHPV133 -,-,2002
skin/rabbit lethal dose (50 percent kill): 805 mg/kgHPV133 -,-,2002
skin/rabbit lethal dose (50 percent kill): 790 µL/kgTXAPA9 28,313,1974
skin/rat lethal dose (50 percent kill): >5000 mg/kgHPV133 -,-,2002
subcutaneous/mouse lowest published lethal dose: 1640 mg/kgBehavioral: General anesthetic

Behavioral: Ataxia

Behavioral: Coma
JPETAB 14,211,1920

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 6120 mg/kg/16W- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
HPV133 -,-,2002
oral/rat lowest published toxic dose: 90 mL/kg/90D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainHPV133 -,-,2002
oral/rat lowest published toxic dose: 180 mL/kg/90D- intermittentBlood: Normocytic anemia

Blood: Luekopenia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV133 -,-,2002
oral/rat lowest published toxic dose: 6 gm/kg/30D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 50(2),70,1985
oral/rat lowest published toxic dose: 6052 mg/kg/17W- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
VPITAR 33(5),48,1974
skin/rat lowest published toxic dose: 90 mL/kg/90D- intermittentBlood: Normocytic anemia

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,135,1994
skin/rat lowest published toxic dose: 14000 mg/kg/10D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV133 -,-,2002

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWTOLED5 140-141,239,2003

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 80836; Number of Industries 44; Total Number of Facilities 10505; Number of Occupations 77; Total Number of Employees Exposed 161595; Total Number of Female Employees Exposed 92702
National Occupational Hazard Survey 1974Hazard Code 80836; Number of Industries 22; Total Number of Facilities 873; Number of Occupations 41; Total Number of Employees Exposed 34310

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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